scholarly journals Effects of macronutrient intake in obesity: a meta-analysis of low-carbohydrate and low-fat diets on markers of the metabolic syndrome

2020 ◽  
Author(s):  
Anouk E M Willems ◽  
Martina Sura–de Jong ◽  
André P van Beek ◽  
Esther Nederhof ◽  
Gertjan van Dijk
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Meta Analysis ◽  
Caloric Intake ◽  
Macronutrient Intake ◽  
Fat Intake ◽  
Low Fat ◽  
The Metabolic Syndrome ◽  
Low Carbohydrate ◽  
Fat Diets

Abstract The metabolic syndrome (MetS) comprises cardiometabolic risk factors frequently found in individuals with obesity. Guidelines to prevent or reverse MetS suggest limiting fat intake, however, lowering carbohydrate intake has gained attention too. The aim for this review was to determine to what extent either weight loss, reduction in caloric intake, or changes in macronutrient intake contribute to improvement in markers of MetS in persons with obesity without cardiometabolic disease. A meta-analysis was performed across a spectrum of studies applying low-carbohydrate (LC) and low-fat (LF) diets. PubMed searches yielded 17 articles describing 12 separate intervention studies assessing changes in MetS markers of persons with obesity assigned to LC (<40% energy from carbohydrates) or LF (<30% energy from fat) diets. Both diets could lead to weight loss and improve markers of MetS. Meta-regression revealed that weight loss most efficaciously reduced fasting glucose levels independent of macronutrient intake at the end of the study. Actual carbohydrate intake and actual fat intake at the end of the study, but not the percent changes in intake of these macronutrients, improved diastolic blood pressure and circulating triglyceride levels, without an effect of weight loss. The homeostatic model assessment of insulin resistance improved with both diets, whereas high-density lipoprotein cholesterol only improved in the LC diet, both irrespective of aforementioned factors. Remarkably, changes in caloric intake did not play a primary role in altering MetS markers. Taken together, these data suggest that, beyond the general effects of the LC and LF diet categories to improve MetS markers, there are also specific roles for weight loss, LC and HF intake, but not reduced caloric intake, that improve markers of MetS irrespective of diet categorization. On the basis of the results from this meta-analysis, guidelines to prevent MetS may need to be re-evaluated.

Low-carbohydrate or low-fat diets for the metabolic syndrome?

2006 ◽  
Vol 6 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Michael L. Dansinger ◽  
Ernst J. Schaefer
Keyword(s):  
Metabolic Syndrome ◽  
Low Fat ◽  
The Metabolic Syndrome ◽  
Low Carbohydrate ◽  
Fat Diets

Abstract MP63: Randomized Trials of Low-Fat vs. Other Diet Interventions on Weight Loss: A Meta-Analysis

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Deirdre K Tobias ◽  
Mu Chen ◽  
Walter Willett ◽  
Frank B Hu
Keyword(s):  
Weight Loss ◽  
Randomized Trials ◽  
Dietary Intervention ◽  
Meta Analysis ◽  
Dietary Interventions ◽  
Low Fat ◽  
Intervention Intensity ◽  
Low Carbohydrate ◽  
Fat Diets

Introduction: The effectiveness of low-fat diets for weight loss has been debated for decades. Dozens of randomized control trials (RCTs) have assessed whether decreasing the intake of total fat leads to weight loss, giving mixed results. Hypothesis: We hypothesized that low-fat dietary interventions do not lead to greater weight loss when comparator diet intervention intensity is considered. Methods: We conducted a systematic review and meta-analysis. RCTs were included if they compared a low-fat dietary intervention to any control diet with at least 1 year of follow-up. We estimated the combined fixed effect inverse variance weighted mean difference of low-fat vs. comparison diets. Several a priori stratified analyses were considered to explore heterogeneity. Results: Fifty studies met inclusion criteria, reporting 1-10 years of follow-up on 70,054 participants. Overall, low-fat dietary interventions resulted in 0.51kg greater weight loss compared to other diets (95% CI = -0.62, -0.40, p<0.001; I2 = 83%). However, when trials where greater attention was given to the low-fat group were excluded, comparator diets led to greater weight loss than low-fat diets (n=30; WMD=0.87, 95% CI=0.56, 1.17, p<0.001). Similarly, when the type of comparator diet was considered, low-fat diets were only beneficial compared to control groups who were simply asked to maintain their usual diet (n=18; WMD = -1.03, 95% CI = -1.18, -0.88, p<0.001). When equal attention was given to intervention groups, low-carbohydrate diets (n=15; WMD = 1.13kg, 95% CI = 0.53, 1.73, p<0.001) and other “healthy” diets without a low-fat component (n=20; WMD = 0.77kg, 95% CI = 0.42, 1.13, p<0.001) led to greater weight loss than low-fat diets. Comparison diets, irrespective of type, were associated with 1.30kg greater weight loss than low-fat diets when the interventions were intended to be isocaloric (n=19; 95% CI = 0.92, 1.69, p<0.001). Conclusions: Low-fat dietary interventions are not more effective than other diets for weight loss when differences in intervention intensity between treatment groups are considered. Rather, evidence from long-term (>=1 year) randomized trials indicates low-carbohydrate or other healthful dietary pattern interventions without a low-fat focus may be more effective for weight loss than low-fat dietary interventions. Further evidence is needed to establish the role of these interventions in longer-term weight loss and weight maintenance.

scholarly journals The Effect of Low-Fat and Low-Carbohydrate Diets on Weight Loss and Lipid Levels: A Systematic Review and Meta-Analysis

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3774
Author(s):  
Shreya Chawla ◽  
Fernanda Tessarolo Silva ◽  
Sofia Amaral Medeiros ◽  
Rania A. Mekary ◽  
Dina Radenkovic
Keyword(s):  
Weight Loss ◽  
Total Cholesterol ◽  
Meta Analysis ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Average Weight ◽  
Low Fat ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate ◽  
Fat Diets

Background: The rise in obesity has emphasised a focus on lifestyle and dietary habits. We aimed to address the debate between low-carbohydrate and low-fat diets and compare their effects on body weight, low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), total cholesterol, and triglycerides in an adult population. Method: Medline and Web of Science were searched for randomised controlled trials (RCTs) comparing low-fat and low-carbohydrate diets up to September 2019. Three independent reviewers extracted data. Risk of bias was assessed using the Cochrane tool. The meta-analysis was stratified by follow-up time using the random-effects models. Results: This meta-analysis of 38 studies assessed a total of 6499 adults. At 6–12 months, pooled analyses of mean differences of low-carbohydrate vs. low-fat diets favoured the low-carbohydrate diet for average weight change (mean difference −1.30 kg; 95% CI −2.02 to −0.57), HDL (0.05 mmol/L; 95% CI 0.03 to 0.08), and triglycerides (TG) (−0.10 mmol/L; −0.16 to −0.04), and favoured the low-fat diet for LDL (0.07 mmol/L; 95% CI 0.02 to 0.12) and total cholesterol (0.10 mmol/L; 95% CI 0.02 to 0.18). Conclusion and Relevance: This meta-analysis suggests that low-carbohydrate diets are effective at improving weight loss, HDL and TG lipid profiles. However, this must be balanced with potential consequences of raised LDL and total cholesterol in the long-term.

THE EFFECTS OF LOW-CARBOHYDRATE VERSUS LOW-FAT DIETS IN OBESE/OVERWEIGHT ADULTS: ONE-YEAR FOLLOW-UP OF A RANDOMIZED TRIAL

2021 ◽  
pp. 27-29
Author(s):  
Maitri Hathi ◽  
Sudesh Kumar
Keyword(s):  
Weight Loss ◽  
Randomized Trial ◽  
Caloric Intake ◽  
Low Fat ◽  
Obese Adults ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate ◽  
One Year ◽  
The One

Aprevious paper reported the six month comparison of weight loss in overweight and/or obese adults randomly assigned to either a VLCK-diet or LF-diet. To review the one year outcomes between these diets 1year follow-up of a randomized trial on 113 overweight/obese adults with a BMI>25 kg/m2; with no abnormalities were randomly selected. Participants who selected VLCK diet received counseling to restrict carbohydrate intake to <30 gram per day and those who selected LF diet received counseling to restrict caloric intake by 500 calories per day with <30% of calories from fat. Changes in weight, Body Mass Index, Body Fat, and Waist Circumference were measured at intervals of rst, third, sixth and twelfth month of participants who completed the one-year follow-up. Participants on the very-low-carbohydrate diet had lost more weight loss than participants on the conventional low-fat diet at 3months, 6month and but the difference at 12months were signicant. Study conclude that participants on a VLCK-diet had more favorable overall outcomes at 1year than did those on a conventional LF-diet. Weight loss was similar between groups.

scholarly journals Increment in Dietary Potassium Predicts Weight Loss in the Treatment of the Metabolic Syndrome

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1256
Author(s):  
Brurya Tal ◽  
Jessica Sack ◽  
Marianna Yaron ◽  
Gabi Shefer ◽  
Assaf Buch ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Caloric Intake ◽  
Caproic Acid ◽  
Dietary Vitamin ◽  
Baseline Body Mass Index ◽  
Potassium Intake ◽  
Multidisciplinary Program ◽  
The Metabolic Syndrome ◽  
Dietary Potassium

Background: In the treatment of obesity/metabolic syndrome, dietary measures traditionally focus on reducing carbohydrate/fat-related caloric intake. The possibility that changes in potassium consumption may be related to the achieved weight loss has not been previously explored. Methods: Sixty-eight participants, with a mean age of 51.6 ± 11.0 years (F/M—30/38), who fulfilled the ATPIII criteria for the metabolic syndrome (MS) were enrolled into a 1-year intensive multidisciplinary program. Nutritional recommendation consisted of a moderate low calorie/high protein Mediterranean diet. Baseline assessment included clinical and biochemical profiling, and body composition. Nutritional components were registered over 7 days before and at the end of 1 year of treatment. Results: Mean baseline body mass index (BMI) was 35 ± 4 kg/m², which declined by 9.4 ± 0.1% after one year of combined intervention. Linear stepwise regression analysis revealed that 45% of the predicted variance of the % decline in BMI was related to increased consumption of dietary potassium (β = −0.865) and caproic acid (β = −0.423) and reduction in the consumption of dietary vitamin B6 (β = 0.542), calcium (β = 0.335), total carbohydrates (β = 0.239) and total caloric intake (β = 0.238; p < 0.001). Notably, the strongest correlate of the decline in BMI was the increase in dietary potassium intake (β = −0.865). Subjects whose achieved decrease in BMI was above the average (n = 30) increased potassium intake by 25% as compared to an increase in dietary potassium intake of only 3% by those whose decline in BMI was below the average (n = 36; p < 0.05). The change in dietary potassium was related to the percent increase in dietary protein (r = 0.433; p < 0.001). Conclusion: An increase in dietary potassium consumption is a previously unrecognized predictor of the achieved reduction in BMI in a weight-loss-oriented multidisciplinary intervention in obesity/MS. Prospective trials are underway to confirm this post-hoc finding.

scholarly journals Endothelial function and weight loss: Comparison of low-carbohydrate and low-fat diets

Obesity ◽  
2013 ◽  
Vol 21 (3) ◽  
pp. 504-509 ◽  
Author(s):  
Emile R. Mohler ◽  
Alexandra A. Sibley ◽  
Richard Stein ◽  
Victor Davila-Roman ◽  
Holly Wyatt ◽  
...  
Keyword(s):  
Weight Loss ◽  
Endothelial Function ◽  
Low Fat ◽  
Low Carbohydrate ◽  
Fat Diets

scholarly journals The mass balance model of obesity explains the weight loss advantage of a low-carbohydrate diet over a isocaloric low-fat diet

2020 ◽  
Author(s):  
Francisco Arencibia-Albite ◽  
Anssi H. Manninen
Keyword(s):  
Weight Loss ◽  
Energy Balance ◽  
Mass Balance ◽  
Balance Model ◽  
Mass Balance Model ◽  
Low Fat ◽  
Macronutrient Composition ◽  
Low Carbohydrate ◽  
Fat Diets ◽  
Weight Stability

Currently, obesity treatment rests on the "calories-in, calories-out" (CICO) rule, formally named the energy balance theory (EBT). It maintains that body weight (BW) increases as food calories are greater than expended calories but decreases when the opposite occurs; hence, weight stability is expected at energy balance meaning that over time energy-in equals energy-out. It follows that dietary regimens with identical energy content should evoke similar amounts of weight and fat loss with only minor differences that follow from diet's macronutrient composition, e.g., diet-induced glycogen depletion and water excretion. A vast collection of evidence shows, however, that low-carbohydrate diets typically result in much greater weight and fat loss than isocaloric low-fat diets. Furthermore, our recent mathematical analysis demonstrated that weight stability coincides with a persistent energy imbalance and not otherwise. As an alternative, the mass balance model (MBM) was proposed that fitted weight loss data and explained the often superior weight loss evoked by low-carbohydrate diets versus low-fat diets. Here, we expand on these observations by computationally contrasting the predictions of both models in two scenarios described in the literature: altering the diet's macronutrient composition while energy intake is kept at weight maintenance level; and the weight loss response as diet composition is changed under untreated type 1 diabetes. Our results indicate that MBM predictions are remarkably accurate while those of the EBT are clearly erroneous. These findings may represent the beginning of a paradigm shift in obesity research.

scholarly journals Low Carbohydrate and Low-Fat Diets: What We Don't Know and Why we Should Know It

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2749 ◽  
Author(s):  
Seid ◽  
Rosenbaum
Keyword(s):  
Weight Loss ◽  
Weight Maintenance ◽  
Caloric Intake ◽  
Saturated Fat ◽  
Conclusive Evidence ◽  
Low Fat ◽  
Low Carbohydrate Diet ◽  
Low Fat Diet ◽  
Low Carbohydrate ◽  
Cholesterol Intake

In the 1940s, the diet-heart hypothesis proposed that high dietary saturated fat and cholesterol intake promoted coronary heart disease in “at-risk“ individuals. This hypothesis prompted federal recommendations for a low-fat diet for “high risk” patients and as a preventive health measure for everyone except infants. The low carbohydrate diet, first used to treat type 1 diabetes, became a popular obesity therapy with the Atkins diet in the 1970s. Its predicted effectiveness was based largely on the hypothesis that insulin is the causa prima of weight gain and regain via hyperphagia and hypometabolism during and after weight reduction, and therefore reduced carbohydrate intake would promote and sustain weight loss. Based on literature reviews, there are insufficient randomized controlled inpatient studies examining the physiological significance of the mechanisms proposed to support one over the other. Outpatient studies can be confounded by poor diet compliance such that the quality and quantity of the energy intake cannot be ascertained. Many studies also fail to separate macronutrient quantity from quality. Overall, there is no conclusive evidence that the degree of weight loss or the duration of reduced weight maintenance are significantly affected by dietary macronutrient quantity beyond effects attributable to caloric intake. Further work is needed.

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