scholarly journals Long-term effects of calcium antagonists on augmentation index in hypertensive patients with chronic kidney diseases

2009 ◽  
Vol 2 (2) ◽  
pp. 192-193 ◽  
Author(s):  
T. Takenaka ◽  
H. Takane ◽  
H. Okada ◽  
Y. Ohno ◽  
H. Suzuki
Keyword(s):  
Calcium Antagonists ◽  
Kidney Diseases ◽  
Augmentation Index ◽  
Long Term Effects ◽  
Chronic Kidney Diseases ◽  
Hypertensive Patients

scholarly journals Mechanisms by Which Dehydration May Lead to Chronic Kidney Disease

2015 ◽  
Vol 66 (Suppl. 3) ◽  
pp. 10-13 ◽  
Author(s):  
C. Roncal-Jimenez ◽  
M.A. Lanaspa ◽  
T. Jensen ◽  
L.G. Sanchez-Lozada ◽  
R.J. Johnson
Keyword(s):  
Chronic Kidney Disease ◽  
Risk Factor ◽  
Kidney Disease ◽  
Central America ◽  
Kidney Diseases ◽  
Long Term Effects ◽  
Acute Renal Dysfunction ◽  
Chronic Kidney Diseases

Dehydration, a condition that characterizes excessive loss of body water, is well known to be associated with acute renal dysfunction; however, it has largely been considered reversible and to be associated with no long-term effects on the kidney. Recently, an epidemic of chronic kidney disease has emerged in Central America in which the major risk factor seems to be recurrent heat-associated dehydration. This has led to studies investigating whether recurrent dehydration may lead to permanent kidney damage. Three major potential mechanisms have been identified, including the effects of vasopressin on the kidney, the activation of the aldose reductase-fructokinase pathway, and the effects of chronic hyperuricemia. The discovery of these pathways has also led to the recognition that mild dehydration may be a risk factor in progression of all types of chronic kidney diseases. Furthermore, there is some evidence that increasing hydration, particularly with water, may actually prevent CKD. Thus, a whole new area of investigation is developing that focuses on the role of water and osmolarity and their influence on kidney function and health.

Abstract 13947: The Acute and Long-term Effects of Transcatheter Aortic Valve Implantation on Aortic Stiffness and Hemodynamics

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Vasiliki Gardikioti ◽  
Dimitrios Terentes-printzios ◽  
Konstantinos Aznaouridis ◽  
George Latsios ◽  
Gerasimos Siasos ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Arterial Stiffness ◽  
Transcatheter Aortic Valve Implantation ◽  
Augmentation Index ◽  
Long Term Effects ◽  
Transcatheter Aortic Valve ◽  
Aortic Valve Implantation ◽  
One Year ◽  
Valve Implantation

Introduction: Transcatheter aortic valve implantation (TAVI) is a procedure that alters dramatically the hemodynamics in patients with severe aortic valve stenosis who undergo this procedure. Hypothesis: We investigated the hypothesis that arterial properties and hemodynamics are affected immediately after TAVI as well as in the long-term. Methods: We enrolled 90 patients (mean age 80.2 ± 8.1 years, 50% males) with severe symptomatic aortic stenosis undergoing TAVI. Carotid-femoral and brachial-ankle pulse wave velocity (cfPWV and baPWV) were used for the assessment of arterial stiffness. Augmentation index corrected for heart rate (AIx@75) and subendocardial viability ratio (SEVR) were measured non-invasively. Measurements were conducted at baseline, after the procedure (during hospitalization) and at 1 year. Results: Acutely after TAVI we observed a statistically significant increase in arterial stiffness (7.5 ± 1.5 m/s vs 8.4 ± 1.9 m/s, p=0.001 for cfPWV and 1,773 ± 459 cm/s vs 2,383 ± 645 cm/s, p<0.001 for baPWV) without a concomitant change in systolic blood pressure (Figure). One year later, arterial stiffness was still increased compared to pre-TAVI measurements (7.5 ± 1.5 m/s vs 8.7 ± 1.7 m/s, p<0.001 for cfPWV and 1,773 ± 459 cm/s vs 2,286 ± 575 cm/s, p<0.001 for baPWV). We also found a decrease in AIx@75 (32.2 ± 12.9 % vs 27.9± 8.4 %, p=0.016) after TAVI that was attenuated at 1-year follow-up (32.2 ± 12.9 % vs 29.8± 9.1 %, p=0.38). SEVR displayed an increase acutely after TAVI (131.2 ± 30.0 % vs 148.4± 36.1 %, p=0.002) and remained improved 1 year after the procedure (131.2 ± 30.0 % vs 146± 32.2 %, p=0.01). Conclusions: In conclusion, shortly after TAVI the aorta exhibits a "stiffer" behavior in response to the acute change in hemodynamics, which settles in the long term. Our findings further elucidate the hemodynamic consequences of TAVI and may entail a prognostic role in this growing population.

BMI is associated with the development of chronic kidney diseases in hypertensive patients with normal renal function

2018 ◽  
Vol 36 (10) ◽  
pp. 2085-2091 ◽  
Author(s):  
Liling Xie ◽  
Binyan Wang ◽  
Chongfei Jiang ◽  
Xianglin Zhang ◽  
Yun Song ◽  
...  
Keyword(s):  
Renal Function ◽  
Normal Renal Function ◽  
Kidney Diseases ◽  
Chronic Kidney Diseases ◽  
Hypertensive Patients

Long-term effects of weight-reducing diets in hypertensive patients

2011 ◽  
Author(s):  
Andrea Siebenhofer ◽  
Klaus Jeitler ◽  
Andrea Berghold ◽  
Andreas Waltering ◽  
Lars G Hemkens ◽  
...  
Keyword(s):  
Long Term Effects ◽  
Hypertensive Patients

Acute and long-term effects of labetalol on systemic and pulmonary haemodynamics in hypertensive patients

1980 ◽  
Vol 17 (1) ◽  
pp. 5-11 ◽  
Author(s):  
T. Lysbo Svendsen ◽  
S. Rasmussen ◽  
O. J. Hartling ◽  
P. E. Nielsen ◽  
J. Trap-Jensen
Keyword(s):  
Long Term Effects ◽  
Hypertensive Patients ◽  
Pulmonary Haemodynamics
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