scholarly journals Reversible bilateral optic disc swelling in a renal patient treated with nitrofurantoin

2008 ◽  
Vol 1 (5) ◽  
pp. 344-345
Author(s):  
E. Pringle ◽  
H. Ho ◽  
E. O'Sullivan ◽  
C. Soper
Keyword(s):  
Optic Disc ◽  
Optic Disc Swelling ◽  
Renal Patient

Protracted Posttraumatic Optic Disc Swelling

Ophthalmology ◽  
1995 ◽  
Vol 102 (11) ◽  
pp. 1628-1631 ◽  
Author(s):  
Michael C. Brodsky ◽  
Kenneth J. Wald ◽  
Sanford Chen ◽  
John J. Weiter
Keyword(s):  
Optic Disc ◽  
Optic Disc Swelling

Optic neuropathy secondary to perhexiline and amiodarone

2021 ◽  
Vol 14 (1) ◽  
pp. e237727
Author(s):  
Yiran Tan ◽  
Paul Sia ◽  
Sumu Simon
Keyword(s):  
Optic Disc ◽  
Optic Neuropathy ◽  
Temporal Artery ◽  
Underlying Mechanism ◽  
Emission Tomography ◽  
Temporal Artery Biopsy ◽  
Ocular Side ◽  
Positron Emission ◽  
Life Threatening ◽  
Optic Disc Swelling

Bilateral optic disc swelling is an important clinical sign for potentially life-threatening and sight-threatening conditions, with the most common being raised intracranial pressure and pseudopapillitis. Perhexiline-related and amiodarone-related optic disc swellings are diagnoses of exclusion. This report describes the diagnosis of a man with perhexiline-induced and amiodarone-induced optic neuropathy after extensive investigation consisting of full ophthalmic examination, biochemical screen, temporal artery biopsy, CT, MRI, positron emission tomography and lumbar puncture. There was partial to complete resolution of optic neuropathy following cessation of the causative medication. We postulate that the underlying mechanism of perhexiline toxicity could be mitochondrial dysfunction related. Our case demonstrates that patients treated with perhexiline and amiodarone should be monitored closely for ocular side effects.

scholarly journals Protracted Postraumatic Optic Disc Swelling

1997 ◽  
Vol 17 (1) ◽  
pp. 75
Author(s):  
Brodsky MC ◽  
Wald KJ ◽  
Chen S ◽  
Weiter JJ.
Keyword(s):  
Optic Disc ◽  
Optic Disc Swelling

Contraceptives, Cerebral Vein Thrombosis, and Choked Discs

2007 ◽  
Vol 17 (4) ◽  
pp. 669-670 ◽  
Author(s):  
A.R. Reddy ◽  
O.C. Backhouse
Keyword(s):  
Case Report ◽  
Optic Disc ◽  
Diagnostic Tests ◽  
Jugular Vein ◽  
Signs And Symptoms ◽  
Cerebral Vein ◽  
Management Options ◽  
Cerebral Vein Thrombosis ◽  
Vein Thrombosis ◽  
Optic Disc Swelling

Purpose To raise awareness of the importance of prompt and appropriate imaging in patients presenting with signs and symptoms suggestive of idiopathic intracranial hypertension. Methods Case report with diagnostic tests and discussion of management options. Results A 15-year-old girl presenting with bilateral optic disc swelling was noted to have extensive thrombosis of intracerebral venous sinuses with the clot extending along the internal jugular vein as inferior as the root of the neck demonstrable on magnetic resonance venography. Conclusions Ophthalmologists should be vigilant in obtaining appropriate imaging in cases of optic disc swelling.

scholarly journals Different Characteristics of Aquaporin-4 and Myelin Oligodendrocyte Glycoprotein Antibody-Seropositive Male Optic Neuritis in China

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Honglu Song ◽  
Huanfen Zhou ◽  
Mo Yang ◽  
Junqing Wang ◽  
Hongjuan Liu ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Optic Neuritis ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Optic Disc ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
Aquaporin 4 ◽  
Optic Disc Swelling ◽  
Male Patients ◽  
Retinal Nerve Fiber

Purpose. To describe different clinical characteristics and prognosis of optic neuritis (ON) in male patients with seropositive aquaporin-4 antibody (AQP4-Ab) or myelin oligodendrocyte glycoprotein antibody (MOG-Ab) in China. Method. Males with ON were recruited from the Neuro-ophthalmology Department of the Chinese People’s Liberation Army, General Hospital from January 2016 to February 2018. They were assigned to two groups based on antibodies status: MOG-Ab-seropositive ON (MOG-ON) and aquaporin-4 Ab-seropositive ON (AQP4-ON). Results. Seventy-six male patients were assessed, including 44 MOG-ON (57.9%) and 32 AQP4-ON (42.1%). The MOG-ON patients were significantly younger at onset compared to the AQP4-ON group (p<0.001). Frequencies of optic disc swelling, presence of abnormal autoimmune antibodies, and elevated levels of CSF IgG were significantly higher in the AQP4-ON group than the MOG-ON group (p=0.040, p=0.016, and p=0.10, respectively). At the final visit, 85.3% of MOG-ON eyes had increased visual acuity (≥0.5) compared to 35.1% of AQP4-ON eyes (p<0.001). The ratio of this steroid-dependent condition is higher in MOG-ON patients than the AQP4-ON group (p<0.001). The ratio of conversion to NMO is higher in the AQP4-ON group than the MOG-ON group, with more AQP4-ON patients developing NMO by the follow-up (p=0.012). MOG-ON patients had thicker average peripapillary retinal nerve fiber layers and macular ganglion cell-inner plexiform than AQP4-ON patients (p=0.008 and p=0.012, respectively). Orbital MRI revealed more AQP4-ON patients had chiasmal involvement than MOG-ON patients (p<0.001). Conclusion. Male MOG-ON patients had different clinical features including earlier age of onset, higher optic disc swelling ratio, better visual acuity recovery, thicker peripapillary retinal nerve fiber and macular ganglion cell-inner plexiform layers, and less chiasmal involvement than male AQP4-ON patients. Serum antibody may be a potential biomarker for determining visual prognosis in male ON.

scholarly journals A Child With Pancytopenia and Optic Disc Swelling

PEDIATRICS ◽  
2019 ◽  
Vol 144 (5) ◽  
pp. e20182887
Author(s):  
Justin Berk ◽  
Deborah Hall ◽  
Inna Stroh ◽  
Caren Armstrong ◽  
Kapil Mishra ◽  
...  
Keyword(s):  
Optic Disc ◽  
Optic Disc Swelling
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