scholarly journals Rituximab for plasma exchange-dependent recurrent focal segmental glomerulosclerosis after renal transplantation

2008 ◽  
Vol 1 (2) ◽  
pp. 85-88 ◽  
Author(s):  
J. K. J. Deegens ◽  
J. F. M. Wetzels
Keyword(s):  
Renal Transplantation ◽  
Plasma Exchange ◽  
Focal Segmental Glomerulosclerosis ◽  
Segmental Glomerulosclerosis

scholarly journals Successful Treatment of Focal Segmental Glomerulosclerosis after Kidney Transplantation with Plasma Exchange and Abatacept in a Patient with Juvenile Rheumatoid Arthritis

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Hannelore Sprenger-Mähr ◽  
Emanuel Zitt ◽  
Afschin Soleiman ◽  
Karl Lhotta
Keyword(s):  
Rheumatoid Arthritis ◽  
Kidney Transplantation ◽  
Renal Transplantation ◽  
Plasma Exchange ◽  
Juvenile Rheumatoid Arthritis ◽  
Focal Segmental Glomerulosclerosis ◽  
Caucasian Patient ◽  
Segmental Glomerulosclerosis ◽  
Allograft Biopsy ◽  
Progression Of Disease

Recurrent focal segmental glomerulosclerosis (FSGS) after renal transplantation is difficult to treat. Recently a series of four patients unresponsive to plasma exchange (PE) and rituximab, who were successfully treated with abatacept, has been reported. We present a 26-year-old Caucasian patient who suffered from juvenile rheumatoid arthritis and developed severe proteinuria eleven days after transplantation. An allograft biopsy was suggestive of recurrent focal segmental glomerulosclerosis. He did not respond to PE therapy. A first dose of abatacept produced partial remission. Four weeks later proteinuria again increased and a second biopsy showed progression of disease. After another ineffective course of PE he was given a second dose of abatacept, which was followed by rapid, complete, and sustained resolution of proteinuria. This treatment caused a significant increase in BK and JC viremia. Whether abatacept ameliorated proteinuria via an effect on podocytes or on the patient’s primary disease remains speculative.

Preventing recurrence of focal segmental glomerulosclerosis following renal transplantation: A case report

2006 ◽  
Vol 10 (8) ◽  
pp. 962-965 ◽  
Author(s):  
Kevin Couloures ◽  
Samuel H. Pepkowitz ◽  
Dennis Goldfinger ◽  
Elaine S. Kamil ◽  
Dechu P. Puliyanda
Keyword(s):  
Case Report ◽  
Renal Transplantation ◽  
Focal Segmental Glomerulosclerosis ◽  
Segmental Glomerulosclerosis

Recurrent Focal Segmental Glomerulosclerosis after Renal Transplantation

1991 ◽  
Vol 14 (2) ◽  
pp. 99-101 ◽  
Author(s):  
A.R. Datta ◽  
V. Sakhuja ◽  
M. Minz ◽  
K. Joshi ◽  
K.S. Chugh
Keyword(s):  
Renal Transplantation ◽  
Focal Segmental Glomerulosclerosis ◽  
Segmental Glomerulosclerosis
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