scholarly journals Lack of independent relationship between age-related kidney function decline and carotid intima-media thickness in a healthy Chinese population

2010 ◽  
Vol 25 (6) ◽  
pp. 1859-1865 ◽  
Author(s):  
L. Han ◽  
X. Bai ◽  
H. Lin ◽  
X. Sun ◽  
X. m. Chen
Keyword(s):  
Kidney Function ◽  
Chinese Population ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Age Related ◽  
Healthy Chinese ◽  
Kidney Function Decline

Abstract P218: Carotid Intima-media Thickness and Incident End-stage Renal Disease: The Atherosclerosis Risk in Communities Study

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Yuanjie Pang ◽  
Yingying Sang ◽  
Shoshana Ballew ◽  
Morgan Grams ◽  
Gerardo Heiss ◽  
...  
Keyword(s):  
Renal Disease ◽  
Kidney Function ◽  
End Stage Renal Disease ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Carotid Imt ◽  
Media Thickness ◽  
Hazard Ratios ◽  
Stage Renal Disease ◽  
End Stage

Introduction: Carotid intima-media thickness (IMT) has been reported to predict kidney function decline. However, whether carotid IMT is associated with a hard kidney endpoint, end-stage renal disease (ESRD), has not been investigated. Hypothesis: We assessed the hypothesis that increased carotid IMT is associated with ESRD risk. Methods: We studied 13,197 ARIC participants at visit 1 (1987-1989) without history of cardiovascular disease including coronary heart disease, stroke and heart failure and assessed whether carotid IMT measured by B-mode ultrasound is associated with ESRD risk using Cox proportional-hazards models. Regarding carotid IMT parameters, we investigated the mean and maximum values of overall and segment-specific (common, bifurcation and internal carotid arteries) measurements. Results: Mean age was 54.0 (SD 5.7) years, and there were 3,373 (25.6%) blacks and 7,370 (55.8%) women. During a median follow-up of 22.7 years, 433 participants developed ESRD (1.4/1,000 person-years). After adjusting for shared risk factors for atherosclerosis and kidney disease, including baseline kidney function, carotid IMT was significantly associated with ESRD risk (hazard ratios between quartiles 4 and 1, 1.43 [95%CI: 1.01-2.04] for overall mean IMT and 1.73 [95%CI: 1.22-2.44] for overall maximum IMT). The associations were largely consistent in demographic and clinical subgroups. When we explored segment-specific IMTs, the associations with ESRD were most robust for bifurcation carotid. The adjusted hazard ratios between quartiles 4 and 1 were 1.48 (95%CI: 1.04-2.11) for mean bifurcation IMT and 1.42 (95%CI: 0.99-2.03) for maximum bifurcation IMT. Conclusions: Carotid IMT was independently associated with incident ESRD in the general population. Our findings suggest the shared etiology between atherosclerosis and ESRD and highlight the importance of monitoring kidney function over time in individuals with subclinical atherosclerosis.

Kidney Function and Progression of Carotid Intima-Media Thickness in a Community Study

2008 ◽  
Vol 51 (4) ◽  
pp. 584-593 ◽  
Author(s):  
Angela M. Desbien ◽  
Michel Chonchol ◽  
Hannes Gnahn ◽  
Dirk Sander
Keyword(s):  
Kidney Function ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Community Study ◽  
Media Thickness

Attenuated Age-related Increase In Carotid Intima-media Thickness In Cardiorespiratory Fit Men And Women

2009 ◽  
Vol 41 ◽  
pp. 67
Author(s):  
Motohiko Miyachi ◽  
Kiyoshi Sanada ◽  
Yuko Gando ◽  
Kenta Yamamoto ◽  
Haruka Murakami ◽  
...  
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Men And Women ◽  
Media Thickness ◽  
Age Related ◽  
Related Increase

Abstract P242: Carotid Plaque Characterization, Stenosis, and Intima-media Thickness According to Age and Gender in a Large Registry Cohort

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Nancy M Boulos ◽  
Julius M Gardin ◽  
Shaista Malik ◽  
John Postley ◽  
Nathan D Wong
Keyword(s):  
Carotid Plaque ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Carotid Ultrasound ◽  
Age And Gender ◽  
Media Thickness ◽  
Age Related ◽  
Stenosis Severity ◽  
And Gender ◽  
Soft Plaque

Background: Carotid intima-media thickness (CIMT) is a well-established predictor of cardiovascular disease events. Not well described, however, is the prevalence of plaque and stenosis severity and how this varies according to extent of CIMT, age, and gender. Methods: We evaluated the extent of carotid plaque and stenosis severity according to CIMT, age and gender in a large CIMT screening registry. We studied 9347 women and 12676 men (n=22,023) who received carotid ultrasound scans. The presence and severity of both carotid plaque and stenosis was compared according to extent of CIMT ( > 1 mm vs. <1 mm), age, and gender using the Chi-square test of proportions. Results: Among those aged <45 to > 80 years the prevalence of CIMT > 1 mm ranged from 0.13 to 29.3% in women and 0.6 to 40.1% in men, stenosis >50% from 0.1% to 14.9% in women and 0.1% to 13.2% in men, and mixed/soft plaque from 7.1% to 66.5% in women and 9.2% to 65.8% in men (all p<0.001 across age). While 6.6% of women and 8.5% of men with CIMT <1mm had >30% stenosis, this increased to 48.6% and 46.0%, respectively, in those with CIMT > 1 mm. Even when CIMT levels were <1 mm, >30% of persons demonstrated mixed or soft plaque. Of those with CIMT > 1mm, more than 70% had such mixed or soft plaque (Figure) and over 40% demonstrated stenoses of 30% or greater. Conclusions: We describe in a large CIMT registry study a substantial age-related increase in both men and women of CIMT, plaque presence and severity, as well as stenosis. Even in those with normal CIMT, mixed or soft plaque potentially prone to rupture was common, demonstrating the value in assessing for plaque when doing carotid ultrasound.

scholarly journals Association between age-related kidney function and vascular subclinical state in a healthy Chinese population

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Nan Wang ◽  
Xiao-Juan Bai ◽  
Lu-Lu Han ◽  
Wen Han ◽  
Xue-Feng Sun ◽  
...  
Keyword(s):  
Kidney Function ◽  
Chinese Population ◽  
Age Related ◽  
Healthy Chinese
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