scholarly journals Everolimus inhibits glomerular endothelial cell proliferation and VEGF, but not long-term recovery in experimental thrombotic microangiopathy

2006 ◽  
Vol 21 (10) ◽  
pp. 2724-2735 ◽  
Author(s):  
Katja Keller ◽  
Christoph Daniel ◽  
Harald Schöcklmann ◽  
Karl-Hans Endlich ◽  
Dontscho Kerjaschki ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cell ◽  
Thrombotic Microangiopathy ◽  
Endothelial Cell Proliferation ◽  
Glomerular Endothelial Cell

scholarly journals Thrombospondin peptides are potent inhibitors of mesangial and glomerular endothelial cell proliferation in vitro and in vivo

1999 ◽  
Vol 55 (6) ◽  
pp. 2236-2249 ◽  
Author(s):  
Christian P.M. Hugo ◽  
Raimund P. Pichler ◽  
Eckhard Schulze-Lohoff ◽  
Felicitas Pröls ◽  
Stephen Adler ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cell ◽  
Endothelial Cell Proliferation ◽  
Glomerular Endothelial Cell ◽  
Proliferation In Vitro

scholarly journals Propyl Gallate Plays a Nephroprotective Role in Early Stage of Diabetic Nephropathy Associated with Suppression of Glomerular Endothelial Cell Proliferation and Angiogenesis

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Shaojiang Tian ◽  
Junming Tang ◽  
Huihui Liu ◽  
Liping Wang ◽  
Jianming Shen ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Diabetic Nephropathy ◽  
Endothelial Cell ◽  
Propyl Gallate ◽  
Early Stage ◽  
Diabetic Rats ◽  
Endothelial Cell Proliferation ◽  
Glomerular Endothelial Cell ◽  
Enos Expression ◽  
Matrix Expansion

There is growing evidence suggesting that glomerular endothelial cell proliferation and angiogenesis may be responsible for the pathophysiological events in the early stage of diabetic nephropathy. This study was designed to investigate the factors related to glomerular endothelial cell proliferation and glomerular angiogenesis and assess the effect of propyl gallate on preventing these disorders in diabetic rats. We found that glomerular hypertrophy, glomerular mesangial matrix expansion, and albuminuria were significantly increased in DN rats. CD31+ endothelial cells significantly increased in glomerulus of diabetic rats. Double immunofluorescence staining showed some structurally defective vasculus tubes in glomerulus. Real-time PCR and western blot demonstrated the glomerular eNOS expression remained at the same level, while remarkable decreased NO productions and suppressed eNOS activities were observed in diabetic rats. Treatment with propyl gallate improved glomerular pathological changes, reduced endothelial cell proliferation, decreased albuminuria, and restored eNOS activity, but did not alter eNOS expression. These data suggest that endothelial cell proliferation and immature angiogenesis may be the contributors to progression of DN. Propyl gallate is a potential novel therapeutic agent on prevention of diabetic nephropathy.

Regulation of bovine glomerular endothelial cell growth in vitro

1989 ◽  
Vol 256 (1) ◽  
pp. C182-C189 ◽  
Author(s):  
B. J. Ballermann
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cells ◽  
Endothelial Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Endothelial Cell Proliferation ◽  
Fibroblast Growth ◽  
Glomerular Endothelial Cell ◽  
Glomerular Endothelial Cells ◽  
Endothelial Cell Growth

To enable the study of glomerular endothelial cell functions and interactions with other glomerular cells, bovine glomerular capillary endothelial cells were established in culture. Selective media were used to facilitate endothelial cell proliferation and to suppress glomerular mesangial cell growth. Glomerular endothelial cells were separated from other cell types by fluorescence-activated cell sorting or, alternatively, by cloning. Glomerular endothelial cells expressed angiotensin I-converting enzyme and factor VIII activity and acetylated LDL uptake, properties generally held to be specific for endothelial cells. Proliferation of subconfluent glomerular endothelial cells was stimulated by basic fibroblast growth factor and, in the presence of heparin sodium, by acidic fibroblast growth factor. Platelet-derived growth factor was without effect on glomerular endothelial cell proliferation. Coculture with mesangial cells markedly inhibited proliferation of subconfluent glomerular endothelial cells. By contrast, medium conditioned by confluent glomerular endothelial cells markedly enhanced proliferation of subconfluent glomerular endothelial cells. These findings suggest that glomerular endothelial cell growth is under autocrine and paracrine control.

scholarly journals Curcumin binds tubulin, induces mitotic catastrophe, and impedes normal endothelial cell proliferation

2013 ◽  
Vol 60 ◽  
pp. 431-438 ◽  
Author(s):  
Steven J.T. Jackson ◽  
Laura L. Murphy ◽  
Richard C. Venema ◽  
Keith W. Singletary ◽  
Andrew J. Young
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cell ◽  
Mitotic Catastrophe ◽  
Endothelial Cell Proliferation
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