scholarly journals Acute acid load in chronic kidney disease increases plasma potassium, plasma aldosterone and urinary renin

2020 ◽  
Vol 35 (10) ◽  
pp. 1821-1823
Author(s):  
Dominique M Bovée ◽  
Joost W Janssen ◽  
Robert Zietse ◽  
Alexander H J. Danser ◽  
Ewout J Hoorn
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Plasma Potassium ◽  
Plasma Aldosterone ◽  
Acid Load ◽  
Potassium Plasma

scholarly journals The Serum Metabolome Identifies Biomarkers of Dietary Acid Load in 2 Studies of Adults with Chronic Kidney Disease

2019 ◽  
Vol 149 (4) ◽  
pp. 578-585 ◽  
Author(s):  
Casey M Rebholz ◽  
Aditya Surapaneni ◽  
Andrew S Levey ◽  
Mark J Sarnak ◽  
Lesley A Inker ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Fruits And Vegetables ◽  
Smoking Status ◽  
Cross Sectional ◽  
Dietary Acid Load ◽  
Nutrition Research ◽  
Net Endogenous Acid Production ◽  
Dietary Acid ◽  
Acid Load

ABSTRACT Background Dietary acid load is a clinically important aspect of the diet that reflects the balance between acid-producing foods, for example, meat and cheese, and base-producing foods, for example, fruits and vegetables. Methods We used metabolomics to identify blood biomarkers of dietary acid load in 2 independent studies of chronic kidney disease patients: the African American Study of Kidney Disease and Hypertension (AASK, n = 689) and the Modification of Diet in Renal Disease (MDRD, n = 356) study. Multivariable linear regression was used to assess the cross-sectional association between serum metabolites whose identity was known (outcome) and dietary acid load (exposure), estimated with net endogenous acid production (NEAP) based on 24-h urine urea nitrogen and potassium, and adjusted for age, sex, race, randomization group, measured glomerular filtration rate, log-transformed urine protein-to-creatinine ratio, history of cardiovascular disease, BMI, and smoking status. Results Out of the 757 known, nondrug metabolites identified in AASK, 26 were significantly associated with NEAP at the Bonferroni threshold for significance (P < 6.6 × 10−5). Twenty-three of the 26 metabolites were also identified in the MDRD study, and 13 of the 23 (57%) were significantly associated with NEAP (P < 2.2 × 10−3), including 5 amino acids (S-methylmethionine, indolepropionylglycine, indolepropionate, N-methylproline, N-δ-acetylornithine), 2 cofactors and vitamins (threonate, oxalate), 1 lipid (chiro-inositol), and 5 xenobiotics (methyl glucopyranoside, stachydrine, catechol sulfate, hippurate, and tartronate). Higher levels of all 13 replicated metabolites were associated with lower NEAP in both AASK and the MDRD study. Conclusion Metabolomic profiling of serum specimens from kidney disease patients in 2 study populations identified 13 replicated metabolites associated with dietary acid load. Additional studies are needed to validate these compounds in healthy populations. These 13 compounds may potentially be used as objective markers of dietary acid load in future nutrition research studies.

Association of dietary acid load with serum bicarbonate in chronic kidney disease (CKD) patients

2020 ◽  
Vol 74 (S1) ◽  
pp. 69-75
Author(s):  
Larissa Rodrigues Neto Angeloco ◽  
Gabriela Cristina Arces de Souza ◽  
Elen Almeida Romão ◽  
Lynda Frassetto ◽  
Paula Garcia Chiarello
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Serum Bicarbonate ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load

scholarly journals Dietary acid load and chronic kidney disease in elderly adults: Protein and potassium intake

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0185069 ◽  
Author(s):  
Byung-Joon Ko ◽  
Yoosoo Chang ◽  
Seungho Ryu ◽  
Eun Mi Kim ◽  
Mi Yeon Lee ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Elderly Adults ◽  
Dietary Acid Load ◽  
Potassium Intake ◽  
Dietary Acid ◽  
Acid Load

scholarly journals The effect of aldosterone and aldosterone blockade on the progression of chronic kidney disease: a randomized placebo-controlled clinical trial

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hitoshi Minakuchi ◽  
Shu Wakino ◽  
Hidenori Urai ◽  
Arata Kurokochi ◽  
Kazuhiro Hasegawa ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Plasma Aldosterone ◽  
Controlled Study ◽  
Ckd Progression ◽  
Mineralocorticoid Receptor Antagonist ◽  
Plasma Aldosterone Concentration ◽  
Ckd Stage

Abstract The progression of chronic kidney disease (CKD) cannot be completely inhibited. We first explored factors contributing to CKD progression in patients with CKD in a prospective observational study. In the next phase, we focused on the effects of aldosterone, conducting a single-blinded placebo-controlled study using the selective mineralocorticoid receptor antagonist (MRA), eplerenone (25 mg/day). We recruited patients with CKD stage 2 and 3 whose plasma aldosterone concentration was above 15 ng/dL based on the prior data of a prospective observational study. In the CKD cohort study (n = 141), baseline plasma aldosterone concentration was identified as an independent contributory factor for the future rate of change in estimated glomerular filtration rate (eGFR). When the cut-off value for aldosterone was set at 14.5 ng/dL, the decline rate was significantly higher in patients with higher plasma aldosterone concentration (− 1.22 ± 0.39 ml/min/1.73 m2/year vs. 0.39 ± 0.40 ml/min/1.73 m2/year, p = 0.0047). In the final intervention study, in the eplerenone group, eGFR dropped at 6 months after the initiation of the study, and thereafter eGFR was maintained until the end of the study. At 24 months and 36 months, eGFR was significantly higher in the eplerenone group than in the placebo group. In conclusion, MRA can be an effective strategy in preventing CKD progression, especially in patients with high plasma aldosterone.

scholarly journals Higher estimated net endogenous acid production with lower intake of fruits and vegetables based on a dietary survey is associated with the progression of chronic kidney disease

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Koji Toba ◽  
Michihiro Hosojima ◽  
Hideyuki Kabasawa ◽  
Shoji Kuwahara ◽  
Toshiko Murayama ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Acid Production ◽  
Protein Intake ◽  
Fruits And Vegetables ◽  
Ckd Progression ◽  
Dietary Acid Load ◽  
Net Endogenous Acid Production ◽  
Dietary Acid ◽  
Acid Load

Abstract Background Dietary acid load has been suggested to mediate the progression of chronic kidney disease (CKD). However, it is unclear what kinds of foods are actually associated with dietary acid load in patients with CKD. The self-administered diet history questionnaire (DHQ), which semi-quantitatively assesses the dietary habits of Japanese individuals through 150 question items, can estimate average daily intake of various foods and nutrients during the previous month. Using the DHQ, we investigated the association of dietary acid load with CKD progression. We also analyzed the kinds of food that significantly affect dietary acid load. Methods Subjects were 96 outpatients with CKD (average estimated glomerular filtration rate [eGFR], 53.0 ± 18.1 ml/min/1.73 m2) at Niigata University Hospital, who had completed the DHQ in 2011. We calculated net endogenous acid production (NEAP) from potassium and protein intake evaluated by the DHQ in order to assess dietary acid load. CKD progression was assessed by comparing eGFR between 2008 and 2014. Results NEAP was not correlated with protein intake (r = 0.088, p = 0.398), but was negatively correlated with potassium intake (r = − 0.748, p < 0.001). Reduction in eGFR from 2008 to 2014 was estimated to be significantly greater in patients with higher NEAP (NEAP > 50.1 mEq/day, n = 45) than in those with lower NEAP (NEAP ≤50.1 mEq/day, n = 50) by 5.9 (95% confidence interval [95%CI], 0.1 to 11.6) ml/min/1.73 m2. According to multiple logistic regression analysis, higher NEAP was significantly associated with lower intake of fruits (odds ratio [OR], 6.454; 95%CI, 2.19 to 19.00), green and yellow vegetables (OR, 5.18; 95%CI, 1.83 to14.66), and other vegetables (OR, 3.87; 95%CI, 1.29 to 11.62). Conclusions Elevated NEAP could be a risk factor for CKD progression. Low intake of fruits and vegetables would increase dietary acid load and might affect the progression of renal dysfunction in Japanese CKD patients.

scholarly journals Plasma aldosterone and its relationship with left ventricular mass in hypertensive patients with early-stage chronic kidney disease

2015 ◽  
Vol 38 (4) ◽  
pp. 276-283 ◽  
Author(s):  
Giuseppe Mulè ◽  
Emilio Nardi ◽  
Laura Guarino ◽  
Valentina Cacciatore ◽  
Giulio Geraci ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Left Ventricular Mass ◽  
Early Stage ◽  
Left Ventricular ◽  
Plasma Aldosterone ◽  
Hypertensive Patients ◽  
Ventricular Mass

scholarly journals Plasma potassium, diuretic use and risk of developing chronic kidney disease in a predominantly White population

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0174686 ◽  
Author(s):  
Lyanne M. Kieneker ◽  
Michele F. Eisenga ◽  
Michel M. Joosten ◽  
Rudolf A. de Boer ◽  
Ron T. Gansevoort ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Predominantly White ◽  
Plasma Potassium ◽  
White Population
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