scholarly journals EZH2 is required for mouse oocyte meiotic maturation by interacting with and stabilizing spindle assembly checkpoint protein BubRI

2016 ◽  
Vol 44 (16) ◽  
pp. 7659-7672 ◽  
Author(s):  
Yi Qu ◽  
Danyu Lu ◽  
Hao Jiang ◽  
Xiaochun Chi ◽  
Hongquan Zhang
Keyword(s):  
Spindle Assembly Checkpoint ◽  
Spindle Assembly ◽  
Mouse Oocyte ◽  
Meiotic Maturation ◽  
Checkpoint Protein ◽  
Oocyte Meiotic Maturation ◽  
Spindle Assembly Checkpoint Protein

Spindle Assembly Checkpoint Protein Dynamics and Roles in Plant Cell Division

2011 ◽  
pp. 142-153
Author(s):  
Marie-Cécile Caillaud ◽  
Laetitia Paganelli ◽  
Philippe Lecomte ◽  
Laurent Deslandes ◽  
Michaël Quentin ◽  
...  
Keyword(s):  
Cell Division ◽  
Protein Dynamics ◽  
Plant Cell ◽  
Spindle Assembly Checkpoint ◽  
Spindle Assembly ◽  
Checkpoint Protein ◽  
Plant Cell Division ◽  
Spindle Assembly Checkpoint Protein

Diethylstilbestrol exposure disrupts mouse oocyte meiotic maturation in vitro through affecting spindle assembly and chromosome alignment

Chemosphere ◽  
2020 ◽  
Vol 249 ◽  
pp. 126182 ◽  
Author(s):  
Zhi-Ming Ding ◽  
Li-Ping Hua ◽  
Muhammad Jamil Ahmad ◽  
Muhammad Safdar ◽  
Fan Chen ◽  
...  
Keyword(s):  
Spindle Assembly ◽  
Mouse Oocyte ◽  
Meiotic Maturation ◽  
Maturation In Vitro ◽  
Chromosome Alignment ◽  
Oocyte Meiotic Maturation

JNK2 Participates in Spindle Assembly during Mouse Oocyte Meiotic Maturation

2011 ◽  
Vol 17 (2) ◽  
pp. 197-205 ◽  
Author(s):  
Xin Huang ◽  
Jing-Shan Tong ◽  
Zhen-Bo Wang ◽  
Cai-Rong Yang ◽  
Shu-Tao Qi ◽  
...  
Keyword(s):  
Polar Body ◽  
Specific Inhibitor ◽  
Germinal Vesicle ◽  
Spindle Assembly ◽  
Mouse Oocyte ◽  
Meiotic Maturation ◽  
Cytoplasmic Microtubule ◽  
Spindle Poles ◽  
First Polar Body ◽  
Oocyte Meiotic Maturation

AbstractIt is well known that c-Jun N-terminal kinase (JNK) plays pivotal roles in various mitotic events, but its function in mammalian oocyte meiosis remains unknown. In this study, we found that no specific JNK2 signal was detected in germinal vesicle stage. JNK2 was associated with the spindles especially the spindle poles and cytoplasmic microtubule organizing centers at prometaphase I, metaphase I, and metaphase II stages. JNK2 became diffusely distributed and associated with the midbody at telophase I stage. Injection of myc-tagged JNK2α1 mRNA into oocytes also revealed its localization on spindle poles. The association of JNK2 with spindle poles was further confirmed by colocalization with the centrosomal proteins, γ-tubulin and Plk1. Nocodazole treatment showed that JNK2 may interact with Plk1 to regulate the spindle assembly. Then we investigated the possible function of JNK2 by JNK2 antibody microinjection and JNK specific inhibitor SP600125 treatment. These two manipulations caused abnormal spindle formation and decreased the rate of first polar body (PB1) extrusion. In addition, inhibition of JNK2 resulted in impaired localization of Plk1. Taken together, our results suggest that JNK2 plays an important role in spindle assembly and PB1 extrusion during mouse oocyte meiotic maturation.

Too MAD or not MAD enough: The duplicitous role of the spindle assembly checkpoint protein MAD2 in cancer

2020 ◽  
Vol 469 ◽  
pp. 11-21 ◽  
Author(s):  
Mark Bates ◽  
Fiona Furlong ◽  
Michael F. Gallagher ◽  
Cathy D. Spillane ◽  
Amanda McCann ◽  
...  
Keyword(s):  
Spindle Assembly Checkpoint ◽  
Spindle Assembly ◽  
Checkpoint Protein ◽  
Spindle Assembly Checkpoint Protein
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