scholarly journals FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response

2014 ◽  
Vol 42 (18) ◽  
pp. 11560-11569 ◽  
Author(s):  
Zhi-Wei Chen ◽  
Bin Liu ◽  
Nai-Wang Tang ◽  
Yun-Hua Xu ◽  
Xiang-Yun Ye ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Binding ◽  
Dna Damage Response ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Single Stranded Dna ◽  
Damage Response

scholarly journals Human single-stranded DNA binding protein 1 (hSSB1, OBFC2B), a critical component of the DNA damage response

2019 ◽  
Vol 86 ◽  
pp. 121-128 ◽  
Author(s):  
Laura V. Croft ◽  
Emma Bolderson ◽  
Mark N. Adams ◽  
Serene El-Kamand ◽  
Ruvini Kariawasam ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Binding ◽  
Dna Damage Response ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Critical Component ◽  
Single Stranded Dna ◽  
Damage Response

scholarly journals DDB2 (Damaged-DNA binding protein 2) in nucleotide excision repair and DNA damage response

Cell Cycle ◽  
2009 ◽  
Vol 8 (24) ◽  
pp. 4067-4071 ◽  
Author(s):  
Tanya Stoyanova ◽  
Nilotpal Roy ◽  
Dragana Kopanja ◽  
Pradip Raychaudhuri ◽  
Srilata Bagchi
Keyword(s):  
Dna Damage ◽  
Dna Binding ◽  
Nucleotide Excision Repair ◽  
Dna Damage Response ◽  
Excision Repair ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Nucleotide Excision ◽  
Damage Response ◽  
Damaged Dna

scholarly journals Role of chromodomain helicase DNA-binding protein 2 in DNA damage response signaling and tumorigenesis

Oncogene ◽  
2009 ◽  
Vol 28 (8) ◽  
pp. 1053-1062 ◽  
Author(s):  
P Nagarajan ◽  
T M Onami ◽  
S Rajagopalan ◽  
S Kania ◽  
R Donnell ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Binding ◽  
Dna Damage Response ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Damage Response

scholarly journals FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein

Blood ◽  
2007 ◽  
Vol 110 (7) ◽  
pp. 2390-2398 ◽  
Author(s):  
Rigu Gupta ◽  
Sudha Sharma ◽  
Joshua A. Sommers ◽  
Mark K. Kenny ◽  
Sharon B. Cantor ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Binding ◽  
Binding Protein ◽  
Critical Role ◽  
Protein A ◽  
Replication Protein A ◽  
Dna Binding Protein ◽  
Replication Protein ◽  
Single Stranded Dna

The BRCA1 associated C-terminal helicase (BACH1, designated FANCJ) is implicated in the chromosomal instability genetic disorder Fanconi anemia (FA) and hereditary breast cancer. A critical role of FANCJ helicase may be to restart replication as a component of downstream events that occur during the repair of DNA cross-links or double-strand breaks. We investigated the potential interaction of FANCJ with replication protein A (RPA), a single-stranded DNA-binding protein implicated in both DNA replication and repair. FANCJ and RPA were shown to coimmunoprecipitate most likely through a direct interaction of FANCJ and the RPA70 subunit. Moreover, dependent on the presence of BRCA1, FANCJ colocalizes with RPA in nuclear foci after DNA damage. Our data are consistent with a model in which FANCJ associates with RPA in a DNA damage-inducible manner and through the protein interaction RPA stimulates FANCJ helicase to better unwind duplex DNA substrates. These findings identify RPA as the first regulatory partner of FANCJ. The FANCJ-RPA interaction is likely to be important for the role of the helicase to more efficiently unwind DNA repair intermediates to maintain genomic stability.

scholarly journals Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response

Cell Research ◽  
2013 ◽  
Vol 23 (10) ◽  
pp. 1215-1228 ◽  
Author(s):  
Yucai Wang ◽  
Xiao Han ◽  
Fangming Wu ◽  
Justin W Leung ◽  
Megan G Lowery ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Binding ◽  
Structure Analysis ◽  
Dna Damage Response ◽  
Binding Activity ◽  
Single Stranded Dna ◽  
Dna Binding Activity ◽  
Damage Response
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