scholarly journals Sumoylation of the THO complex regulates the biogenesis of a subset of mRNPs

2014 ◽  
Vol 42 (8) ◽  
pp. 5043-5058 ◽  
Author(s):  
Hugo Bretes ◽  
Jérôme O. Rouviere ◽  
Thibaut Leger ◽  
Marlene Oeffinger ◽  
Frédéric Devaux ◽  
...  
Keyword(s):  
Tho Complex

scholarly journals The THO complex cooperates with the nuclear RNA surveillance machinery to control small nucleolar RNA expression

2012 ◽  
Vol 40 (20) ◽  
pp. 10240-10253 ◽  
Author(s):  
Marc Larochelle ◽  
Jean-François Lemay ◽  
François Bachand
Keyword(s):  
Rna Expression ◽  
Small Nucleolar Rna ◽  
Rna Surveillance ◽  
Nuclear Rna ◽  
Tho Complex ◽  
Nucleolar Rna

scholarly journals The THO Complex Non-Cell-Autonomously Represses Female Germline Specification through the TAS3-ARF3 Module

2017 ◽  
Vol 27 (11) ◽  
pp. 1597-1609.e2 ◽  
Author(s):  
Zhenxia Su ◽  
Lihua Zhao ◽  
Yuanyuan Zhao ◽  
Shaofang Li ◽  
SoYoun Won ◽  
...  
Keyword(s):  
Tho Complex ◽  
Female Germline

Transcriptional factor ENY2 promotes recruitment of the THO complex to the hsp70 gene of Drosophila melanogaster

2010 ◽  
Vol 434 (1) ◽  
pp. 227-231 ◽  
Author(s):  
A. V. Orlova ◽  
D. V. Kopytova ◽  
A. N. Krasnov ◽  
E. N. Nabirochkina ◽  
Y. V. Ilyin ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Transcriptional Factor ◽  
Hsp70 Gene ◽  
Tho Complex

scholarly journals Correction: The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell Cycle and Development

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0160138
Author(s):  
Maikel Castellano-Pozo ◽  
Tatiana García-Muse ◽  
Andrés Aguilera
Keyword(s):  
Cell Cycle ◽  
Caenorhabditis Elegans ◽  
Mitotic Cell ◽  
Mitotic Cell Cycle ◽  
Tho Complex

Abstract A090: A novel THO complex member LENG8 connects mRNP export, genome integrity and tumorigenesis

2019 ◽  
Author(s):  
Nan Zhang ◽  
Yongxu Zhao ◽  
Jianxia Chen ◽  
Qiurong Ding ◽  
Feng Liu
Keyword(s):  
Genome Integrity ◽  
Tho Complex

scholarly journals Following Temperature Stress, Export of Heat Shock mRNA Occurs Efficiently in Cells with Mutations in Genes Normally Important for mRNA Export

2007 ◽  
Vol 6 (3) ◽  
pp. 505-513 ◽  
Author(s):  
Christiane Rollenhagen ◽  
Christine A. Hodge ◽  
Charles N. Cole
Keyword(s):  
Heat Shock ◽  
Binding Proteins ◽  
Fluorescent Protein ◽  
Mrna Export ◽  
Temperature Sensitive ◽  
Mrna Binding Proteins ◽  
Tho Complex ◽  
Green Fluorescent ◽  
Mrna Binding

ABSTRACT Heat shock leads to accumulation of polyadenylated RNA in nuclei of Saccharomyces cerevisiae cells, transcriptional induction of heat shock genes, and efficient export of polyadenylated heat shock mRNAs. These studies were conducted to examine the requirements for export of mRNA following heat shock. We used in situ hybridization to detect SSA4 mRNA (encoding Hsp70) and flow cytometry to measure the amount of Ssa4p-green fluorescent protein (GFP) produced following heat shock. Npl3p and Yra1p are mRNA-binding proteins recruited to nascent mRNAs and are essential for proper mRNA biogenesis and export. Heat shock mRNA was exported efficiently in temperature-sensitive npl3, yra1, and npl3 yra1 mutant strains. Nevertheless, Yra1p was recruited to heat shock mRNA, as were Nab2p and Npl3p. Interestingly, Yra1p was not recruited to heat shock mRNA in yra1-1 cells, suggesting that Npl3p is required for recruitment of Yra1p. The THO complex, which functions in transcription elongation and in recruitment of Yra1p, was not required for heat shock mRNA export, although normal mRNA export is impaired in growing cells lacking THO complex proteins. Taken together, these studies indicate that export following heat shock depends upon fewer factors than does mRNA export in growing cells. Furthermore, even though some mRNA-binding proteins are dispensable for efficient export of heat shock mRNA, those that are present in nuclei of heat shocked cells were recruited to heat shock mRNA.

scholarly journals Structural Characterization of the Saccharomyces cerevisiae THO Complex by Small-Angle X-Ray Scattering

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e103470 ◽  
Author(s):  
Jesper Buchhave Poulsen ◽  
Lee Edward Sanderson ◽  
Emil Dandanell Agerschou ◽  
Emil Dedic ◽  
Thomas Boesen ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Structural Characterization ◽  
Small Angle ◽  
X Ray ◽  
X Ray Scattering ◽  
Tho Complex ◽  
Ray Scattering
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