scholarly journals Epistatic role of base excision repair and mismatch repair pathways in mediating cisplatin cytotoxicity

2013 ◽  
Vol 41 (15) ◽  
pp. 7332-7343 ◽  
Author(s):  
Anbarasi Kothandapani ◽  
Akshada Sawant ◽  
Venkata Srinivas Mohan Nimai Dangeti ◽  
Robert W. Sobol ◽  
Steve M. Patrick
Keyword(s):  
Mismatch Repair ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Repair Pathways ◽  
Base Excision

scholarly journals Contribution of Base Excision Repair, Nucleotide Excision Repair, and DNA Recombination to Alkylation Resistance of the Fission Yeast Schizosaccharomyces pombe

2000 ◽  
Vol 182 (8) ◽  
pp. 2104-2112 ◽  
Author(s):  
Asli Memisoglu ◽  
Leona Samson
Keyword(s):  
Dna Repair ◽  
Schizosaccharomyces Pombe ◽  
Nucleotide Excision Repair ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Dna Recombination ◽  
Nucleotide Excision ◽  
Repair Pathways ◽  
Base Excision

ABSTRACT DNA damage is unavoidable, and organisms across the evolutionary spectrum possess DNA repair pathways that are critical for cell viability and genomic stability. To understand the role of base excision repair (BER) in protecting eukaryotic cells against alkylating agents, we generated Schizosaccharomyces pombe strains mutant for the mag1 3-methyladenine DNA glycosylase gene. We report that S. pombe mag1 mutants have only a slightly increased sensitivity to methylation damage, suggesting that Mag1-initiated BER plays a surprisingly minor role in alkylation resistance in this organism. We go on to show that other DNA repair pathways play a larger role than BER in alkylation resistance. Mutations in genes involved in nucleotide excision repair (rad13) and recombinational repair (rhp51) are much more alkylation sensitive thanmag1 mutants. In addition, S. pombe mutant for the flap endonuclease rad2 gene, whose precise function in DNA repair is unclear, were also more alkylation sensitive thanmag1 mutants. Further, mag1 andrad13 interact synergistically for alkylation resistance, and mag1 and rhp51 display a surprisingly complex genetic interaction. A model for the role of BER in the generation of alkylation-induced DNA strand breaks in S. pombe is discussed.

Differential role of Wnt signaling and base excision repair pathways in gastric adenocarcinoma aggressiveness

2016 ◽  
Vol 17 (4) ◽  
pp. 505-517 ◽  
Author(s):  
Alireza Korourian ◽  
Raheleh Roudi ◽  
Ahmad Shariftabrizi ◽  
Elham Kalantari ◽  
Kambiz Sotoodeh ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Gastric Adenocarcinoma ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Repair Pathways ◽  
Base Excision

scholarly journals Damage sensor role of UV-DDB during base excision repair

2019 ◽  
Vol 26 (8) ◽  
pp. 695-703 ◽  
Author(s):  
Sunbok Jang ◽  
Namrata Kumar ◽  
Emily C. Beckwitt ◽  
Muwen Kong ◽  
Elise Fouquerel ◽  
...  
Keyword(s):  
Base Excision Repair ◽  
Excision Repair ◽  
Base Excision

scholarly journals The Role of Base Excision Repair in the Sensitivity and Resistance to Temozolomide-Mediated Cell Death

2005 ◽  
Vol 65 (14) ◽  
pp. 6394-6400 ◽  
Author(s):  
Ram N. Trivedi ◽  
Karen H. Almeida ◽  
Jamie L. Fornsaglio ◽  
Sandra Schamus ◽  
Robert W. Sobol
Keyword(s):  
Cell Death ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Base Excision
Sign in / Sign up

Export Citation Format

Share Document