scholarly journals Chronic low-dose ultraviolet-induced mutagenesis in nucleotide excision repair-deficient cells

2012 ◽  
Vol 40 (17) ◽  
pp. 8406-8415 ◽  
Author(s):  
Nami Haruta ◽  
Yoshino Kubota ◽  
Takashi Hishida
Keyword(s):  
Nucleotide Excision Repair ◽  
Low Dose ◽  
Excision Repair ◽  
Nucleotide Excision ◽  
Induced Mutagenesis

SPT4 increases UV-induced mutagenesis in yeast through impaired nucleotide excision repair

2013 ◽  
Vol 9 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Mi-Sun Kang ◽  
Sung-Lim Yu ◽  
Ho-Yeol Kim ◽  
Hyun-Sook Lim ◽  
Sung-Keun Lee
Keyword(s):  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Nucleotide Excision ◽  
Induced Mutagenesis

scholarly journals Retracted: AKAP12 mediates PKA-induced phosphorylation of ATR to enhance nucleotide excision repair

2016 ◽  
Vol 44 (22) ◽  
pp. 10711-10726 ◽  
Author(s):  
Stuart G. Jarrett ◽  
Erin M. Wolf Horrell ◽  
John A. D'Orazio
Keyword(s):  
Dna Damage ◽  
Nucleotide Excision Repair ◽  
Nuclear Translocation ◽  
Excision Repair ◽  
Critical Role ◽  
Loss Of Function ◽  
Melanocortin 1 Receptor ◽  
Nucleotide Excision ◽  
Anchoring Protein ◽  
Induced Mutagenesis

Abstract Loss-of-function in melanocortin 1 receptor (MC1R), a GS protein-coupled receptor that regulates signal transduction through cAMP and protein kinase A (PKA) in melanocytes, is a major inherited melanoma risk factor. Herein, we report a novel cAMP-mediated response for sensing and responding to UV-induced DNA damage regulated by A-kinase-anchoring protein 12 (AKAP12). AKAP12 is identified as a necessary participant in PKA-mediated phosphorylation of ataxia telangiectasia mutated and Rad3-related (ATR) at S435, a post-translational event required for cAMP-enhanced nucleotide excision repair (NER). Moreover, UV exposure promotes ATR-directed phosphorylation of AKAP12 at S732, which promotes nuclear translocation of AKAP12–ATR-pS435. This complex subsequently recruits XPA to UV DNA damage and enhances 5΄ strand incision. Preventing AKAP12's interaction with PKA or with ATR abrogates ATR-pS435 accumulation, delays recruitment of XPA to UV-damaged DNA, impairs NER and increases UV-induced mutagenesis. Our results define a critical role for AKAP12 as an UV-inducible scaffold for PKA-mediated ATR phosphorylation, and identify a repair complex consisting of AKAP12–ATR-pS435-XPA at photodamage, which is essential for cAMP-enhanced NER.

scholarly journals The effect of essential oil of basil (Ocimum basilicum L.) on UV-induced mutagenesis in Escherichia coli and Saccharomyces cerevisiae

2008 ◽  
Vol 60 (1) ◽  
pp. 93-102 ◽  
Author(s):  
Jasna Stanojevic ◽  
Tanja Beric ◽  
Biljana Opacic ◽  
Branka Vukovic-Gacic ◽  
Draga Simic ◽  
...  
Keyword(s):  
Essential Oil ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Ocimum Basilicum ◽  
Major Constituent ◽  
Spontaneous Mutagenesis ◽  
E Coli ◽  
Antimutagenic Effect ◽  
Nucleotide Excision ◽  
Induced Mutagenesis

The antimutagenic potential of essential oil (EO) of basil (Ocimum basilicum L.) and its major constituent linalool were studied with the E. coli K12 and S.cerevisiae D7 assays. In the E. coli assay, EO and linalool inhibited UV-induced mutagenesis in a repair-proficient strain, but had no effect on spontaneous mutagenesis in repair-proficient, nucleotide excision repair-deficient, and mismatch-deficient strains. By testing participation of different mechanisms involved in antimutagenesis, it was concluded that the antimutagenic effect against UV-induced mutagenesis involved decrease of protein synthesis and cell proliferation which led to increased efficiency of nucleotide excision repair. An antimutagenic effect of basil derivatives in S. cerevisiae was not detected.

Influence of nucleotide excision repair on N-hydroxy-2-acetylaminofluorene-induced mutagenesis studied in λlacZ-transgenic mice

1998 ◽  
Vol 31 (1) ◽  
pp. 41-47 ◽  
Author(s):  
Anita F. W. Frijhoff ◽  
Cyrille A. M. Krul ◽  
Annemieke de Vries ◽  
Marco C. J. M. Kelders ◽  
Geert Weeda ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Nucleotide Excision ◽  
Induced Mutagenesis

scholarly journals Nucleotide Excision Repair Genes are Upregulated by Low-Dose Artificial Ultraviolet B: Evidence of a Photoprotective SOS Response?

2001 ◽  
Vol 117 (6) ◽  
pp. 1490-1497 ◽  
Author(s):  
Tomoko Maeda ◽  
Prescillia P.S. Chua ◽  
Michelle T. Chong ◽  
Adrian B.T. Sim ◽  
Victor A. Tron ◽  
...  
Keyword(s):  
Nucleotide Excision Repair ◽  
Low Dose ◽  
Excision Repair ◽  
Sos Response ◽  
Ultraviolet B ◽  
Nucleotide Excision ◽  
Repair Genes

Modeling nucleotide excision repair and its impact on UV-induced mutagenesis during SOS-response in bacterial cells

2015 ◽  
Vol 364 ◽  
pp. 7-20 ◽  
Author(s):  
Aleksandr N. Bugay ◽  
Evgeny A. Krasavin ◽  
Aleksandr Yu. Parkhomenko ◽  
Maria A. Vasilyeva
Keyword(s):  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Sos Response ◽  
Bacterial Cells ◽  
Nucleotide Excision ◽  
Induced Mutagenesis
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