scholarly journals The biological and structural characterization of Mycobacterium tuberculosis UvrA provides novel insights into its mechanism of action

2011 ◽  
Vol 39 (16) ◽  
pp. 7316-7328 ◽  
Author(s):  
Franca Rossi ◽  
Jasbeer Singh Khanduja ◽  
Alessio Bortoluzzi ◽  
Joanna Houghton ◽  
Peter Sander ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Mechanism Of Action ◽  
Structural Characterization

scholarly journals Structural characterization of VapB46 antitoxin from Mycobacterium tuberculosis : insights into VapB46– DNA binding

FEBS Journal ◽  
2019 ◽  
Vol 286 (6) ◽  
pp. 1174-1190 ◽  
Author(s):  
Madhurima Roy ◽  
Anirban Kundu ◽  
Anirban Bhunia ◽  
Sujoy Das Gupta ◽  
Soumya De ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Dna Binding ◽  
Structural Characterization

scholarly journals First Structural Characterization of a Bon-Domain in a Protein from Mycobacterium Tuberculosis: OmpATb Tracks toward an Oligomerization Process to form a Cell Wall Pore

2010 ◽  
Vol 98 (3) ◽  
pp. 648a
Author(s):  
Daniel Auguin ◽  
Yinshan Yang ◽  
Stephane Delbecq ◽  
Emilie Dumas ◽  
Virginie Molle ◽  
...  
Keyword(s):  
Cell Wall ◽  
Mycobacterium Tuberculosis ◽  
Structural Characterization ◽  
A Cell

Purification and structural characterization of Mce4A from Mycobacterium tuberculosis

2016 ◽  
Vol 93 ◽  
pp. 235-241 ◽  
Author(s):  
Shagufta Khan ◽  
Asimul Islam ◽  
Md. Imtaiyaz Hassan ◽  
Faizan Ahmad
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Structural Characterization

scholarly journals Kinetic and Structural Characterization of the Interaction of 6-Methylidene Penem 2 with the β-Lactamase from Mycobacterium tuberculosis

Biochemistry ◽  
2015 ◽  
Vol 54 (36) ◽  
pp. 5657-5664 ◽  
Author(s):  
Saugata Hazra ◽  
Sebastian G. Kurz ◽  
Kerstin Wolff ◽  
Liem Nguyen ◽  
Robert A. Bonomo ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Structural Characterization

scholarly journals Multiple-stage Precursor Ion Separation and High Resolution Mass Spectrometry toward Structural Characterization of 2,3-Diacyltrehalose Family from Mycobacterium tuberculosis

Separations ◽  
2019 ◽  
Vol 6 (1) ◽  
pp. 4 ◽  
Author(s):  
Cheryl Frankfater ◽  
Robert Abramovitch ◽  
Georgiana Purdy ◽  
John Turk ◽  
Laurent Legentil ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mycobacterium Tuberculosis ◽  
High Resolution ◽  
Structural Characterization ◽  
High Resolution Mass Spectrometry ◽  
Complex Mixture ◽  
Fatty Acyl ◽  
High Resolution Mass ◽  
Resolution Mass

Mass spectrometry (MS)-based precursor ion isolation, collision-induced dissociation (CID) fragmentation, and detection using linear ion-trap multiple-stage mass spectrometry (LIT MSn) in combination with high resolution mass spectrometry (HRMS) provides a unique tool for structural characterization of complex mixture without chromatographic separation. This approach permits not only separation of various lipid families and their subfamilies, but also stereoisomers, thereby, revealing the structural details. In this report, we describe the LIT MSn approach to unveil the structures of a 2,3-diacyl trehalose (DAT) family isolated from the cell envelope of Mycobacterium tuberculosis, in which more than 30 molecular species, and each species consisting of up to six isomeric structures were found. LIT MSn performed on both [M + Na]+ and [M + HCO2]− ions of DAT yield complimentary structural information for near complete characterization of the molecules, including the location of the fatty acyl substituents on the trehalose backbone. This latter information is based on the findings of the differential losses of the two fatty acyl chains in the MS2 and MS3 spectra; while the product ion spectra from higher stage LIT MSn permit confirmation of the structural assignment.

scholarly journals Structural Characterization of the Multidomain Regulatory Protein Rv1364c from Mycobacterium tuberculosis

Structure ◽  
2011 ◽  
Vol 19 (1) ◽  
pp. 56-69 ◽  
Author(s):  
Jack King-Scott ◽  
Petr V. Konarev ◽  
Santosh Panjikar ◽  
Rositsa Jordanova ◽  
Dmitri I. Svergun ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Structural Characterization ◽  
Regulatory Protein
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