scholarly journals Cellular heat shock factor 1 positively regulates human immunodeficiency virus-1 gene expression and replication by two distinct pathways

2011 ◽  
Vol 39 (14) ◽  
pp. 5879-5892 ◽  
Author(s):  
Pratima Rawat ◽  
Debashis Mitra
Keyword(s):  
Gene Expression ◽  
Human Immunodeficiency Virus ◽  
Heat Shock ◽  
Heat Shock Factor ◽  
Heat Shock Factor 1 ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1

Thermal acclimation changes DNA-binding activity of heat shock factor 1(HSF1) in the gobyGillichthys mirabilis: implications for plasticity in the heat-shock response in natural populations

2002 ◽  
Vol 205 (20) ◽  
pp. 3231-3240 ◽  
Author(s):  
Bradley A. Buckley ◽  
Gretchen E. Hofmann
Keyword(s):  
Gene Expression ◽  
Heat Shock ◽  
Heat Shock Response ◽  
Environmental Control ◽  
Heat Shock Factor ◽  
Thermal Acclimation ◽  
Model Systems ◽  
Threshold Temperature ◽  
Heat Shock Factor 1 ◽  
Shock Response

SUMMARYThe intracellular build-up of thermally damaged proteins following exposure to heat stress results in the synthesis of a family of evolutionarily conserved proteins called heat shock proteins (Hsps) that act as molecular chaperones, protecting the cell against the aggregation of denatured proteins. The transcriptional regulation of heat shock genes by heat shock factor 1(HSF1) has been extensively studied in model systems, but little research has focused on the role HSF1 plays in Hsp gene expression in eurythermal organisms from broadly fluctuating thermal environments. The threshold temperature for Hsp induction in these organisms shifts with the recent thermal history of the individual but the mechanism by which this plasticity in Hsp induction temperature is achieved is unknown. We examined the effect of thermal acclimation on the heat-activation of HSF1 in the eurythermal teleost Gillichthys mirabilis. After a 5-week acclimation period (at 13, 21 or 28°C) the temperature of HSF1 activation was positively correlated with acclimation temperature. HSF1 activation peaked at 27°C in fish acclimated to 13°C, at 33°C in the 21°C group, and at 36°C in the 28°C group. Concentrations of both HSF1 and Hsp70 in the 28°C group were significantly higher than in the colder acclimated fish. Plasticity in HSF1 activation may be important to the adjustable nature of the heat shock response in eurythermal organisms and the environmental control of Hsp gene expression.

scholarly journals Alcohol Regulates Gene Expression in Neurons via Activation of Heat Shock Factor 1

2007 ◽  
Vol 27 (47) ◽  
pp. 12957-12966 ◽  
Author(s):  
L. Pignataro ◽  
A. N. Miller ◽  
L. Ma ◽  
S. Midha ◽  
P. Protiva ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heat Shock ◽  
Heat Shock Factor ◽  
Heat Shock Factor 1

scholarly journals Eye-specific gene expression following embryonic ethanol exposure in zebrafish: Roles for heat shock factor 1

2014 ◽  
Vol 43 ◽  
pp. 111-124 ◽  
Author(s):  
Bhavani Kashyap ◽  
Laurel Pegorsch ◽  
Ruth A. Frey ◽  
Chi Sun ◽  
Eric A. Shelden ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heat Shock ◽  
Heat Shock Factor ◽  
Ethanol Exposure ◽  
Specific Gene ◽  
Heat Shock Factor 1 ◽  
Specific Gene Expression

scholarly journals Human immunodeficiency virus-1 Nef protein interacts with Tat and enhances HIV-1 gene expression

FEBS Letters ◽  
2003 ◽  
Vol 548 (1-3) ◽  
pp. 37-42 ◽  
Author(s):  
Ajith Mathew Joseph ◽  
Jayashree S Ladha ◽  
Manoj Mojamdar ◽  
Debashis Mitra
Keyword(s):  
Gene Expression ◽  
Human Immunodeficiency Virus ◽  
Immunodeficiency Virus ◽  
Hiv 1 ◽  
Human Immunodeficiency Virus 1
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