scholarly journals SNPinfo: integrating GWAS and candidate gene information into functional SNP selection for genetic association studies

2009 ◽  
Vol 37 (suppl_2) ◽  
pp. W600-W605 ◽  
Author(s):  
Zongli Xu ◽  
Jack A. Taylor
Keyword(s):  
Candidate Gene ◽  
Genetic Association ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Selection For ◽  
Gene Information ◽  
Functional Snp

scholarly journals A fast multilocus test with adaptive SNP selection for large-scale genetic-association studies

2013 ◽  
Vol 22 (5) ◽  
pp. 696-702 ◽  
Author(s):  
Han Zhang ◽  
Jianxin Shi ◽  
Faming Liang ◽  
William Wheeler ◽  
Rachael Stolzenberg-Solomon ◽  
...  
Keyword(s):  
Genetic Association ◽  
Large Scale ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Selection For

Entropy-based SNP selection for genetic association studies

2003 ◽  
Vol 114 (1) ◽  
pp. 36-43 ◽  
Author(s):  
Jochen Hampe ◽  
Stefan Schreiber ◽  
Michael Krawczak
Keyword(s):  
Genetic Association ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Selection For

SNP Subset Selection for Genetic Association Studies

2003 ◽  
Vol 67 (6) ◽  
pp. 543-556 ◽  
Author(s):  
M. C. Byng ◽  
J. C. Whittaker ◽  
A. P. Cuthbert ◽  
C. G. Mathew ◽  
C. M. Lewis
Keyword(s):  
Genetic Association ◽  
Association Studies ◽  
Subset Selection ◽  
Genetic Association Studies ◽  
Selection For

scholarly journals Fine scale human genetic structure in three regions of Cameroon reveals episodic diversifying selection

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kevin K. Esoh ◽  
Tobias O. Apinjoh ◽  
Steven G. Nyanjom ◽  
Ambroise Wonkam ◽  
Emile R. Chimusa ◽  
...  
Keyword(s):  
Genetic Structure ◽  
Ethnic Groups ◽  
Genetic Association ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Genomic Region ◽  
Sub Saharan Africa ◽  
Genome Wide Association Studies ◽  
Fine Scale ◽  
Sub Saharan

AbstractInferences from genetic association studies rely largely on the definition and description of the underlying populations that highlight their genetic similarities and differences. The clustering of human populations into subgroups (population structure) can significantly confound disease associations. This study investigated the fine-scale genetic structure within Cameroon that may underlie disparities observed with Cameroonian ethnicities in malaria genome-wide association studies in sub-Saharan Africa. Genotype data of 1073 individuals from three regions and three ethnic groups in Cameroon were analyzed using measures of genetic proximity to ascertain fine-scale genetic structure. Model-based clustering revealed distinct ancestral proportions among the Bantu, Semi-Bantu and Foulbe ethnic groups, while haplotype-based coancestry estimation revealed possible longstanding and ongoing sympatric differentiation among individuals of the Foulbe ethnic group, and their Bantu and Semi-Bantu counterparts. A genome scan found strong selection signatures in the HLA gene region, confirming longstanding knowledge of natural selection on this genomic region in African populations following immense disease pressure. Signatures of selection were also observed in the HBB gene cluster, a genomic region known to be under strong balancing selection in sub-Saharan Africa due to its co-evolution with malaria. This study further supports the role of evolution in shaping genomes of Cameroonian populations and reveals fine-scale hierarchical structure among and within Cameroonian ethnicities that may impact genetic association studies in the country.

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