scholarly journals A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance

2008 ◽  
Vol 36 (17) ◽  
pp. 5635-5644 ◽  
Author(s):  
Carmen Losasso ◽  
Erica Cretaio ◽  
Paola Fiorani ◽  
Ilda D’Annessa ◽  
Giovanni Chillemi ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Dna Binding ◽  
Single Mutation ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Topoisomerase Ib

scholarly journals In Vitro and In Silico Characterization of an Antimalarial Compound with Antitumor Activity Targeting Human DNA Topoisomerase IB

2021 ◽  
Vol 22 (14) ◽  
pp. 7455
Author(s):  
Bini Chhetri Soren ◽  
Jagadish Babu Dasari ◽  
Alessio Ottaviani ◽  
Beatrice Messina ◽  
Giada Andreotti ◽  
...  
Keyword(s):  
Enzyme Reaction ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Topoisomerase Ib ◽  
Topological State ◽  
Cleavage Step ◽  
Dynamics Simulations ◽  
In Silico Characterization ◽  
Dna Complex

Human DNA topoisomerase IB controls the topological state of supercoiled DNA through a complex catalytic cycle that consists of cleavage and religation reactions, allowing the progression of fundamental DNA metabolism. The catalytic steps of human DNA topoisomerase IB were analyzed in the presence of a drug, obtained by the open-access drug bank Medicines for Malaria Venture. The experiments indicate that the compound strongly and irreversibly inhibits the cleavage step of the enzyme reaction and reduces the cell viability of three different cancer cell lines. Molecular docking and molecular dynamics simulations suggest that the drug binds to the human DNA topoisomerase IB-DNA complex sitting inside the catalytic site of the enzyme, providing a molecular explanation for the cleavage-inhibition effect. For all these reasons, the aforementioned drug could be a possible lead compound for the development of an efficient anti-tumor molecule targeting human DNA topoisomerase IB.

Comparative studies of oxindolimine-metal complexes as inhibitors of human DNA topoisomerase IB

2018 ◽  
Vol 186 ◽  
pp. 85-94 ◽  
Author(s):  
Silvia Castelli ◽  
Marcos Brown Gonçalves ◽  
Prafulla Katkar ◽  
Gabriela Cristina Stuchi ◽  
Ricardo Alexandre Alves Couto ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Comparative Studies ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Topoisomerase Ib

scholarly journals Characterization of DNA Binding by the Isolated N-Terminal Domain of Vaccinia Virus DNA Topoisomerase IB

Biochemistry ◽  
2017 ◽  
Vol 56 (26) ◽  
pp. 3307-3317 ◽  
Author(s):  
Benjamin Reed ◽  
Lyudmila Yakovleva ◽  
Stewart Shuman ◽  
Ranajeet Ghose
Keyword(s):  
Dna Binding ◽  
Vaccinia Virus ◽  
Dna Topoisomerase ◽  
Terminal Domain ◽  
Topoisomerase Ib

Mutation P732L in Human DNA Topoisomerase IIβ Abolishes DNA Cleavage in the Presence of Calcium and Confers Drug Resistance

2005 ◽  
Vol 69 (1) ◽  
pp. 130-139 ◽  
Author(s):  
Chrysoula Leontiou ◽  
Jeremy H. Lakey ◽  
Robert Lightowlers ◽  
Rozalind M. Turnbull ◽  
Caroline A. Austin
Keyword(s):  
Drug Resistance ◽  
Dna Cleavage ◽  
Dna Topoisomerase ◽  
Human Dna

Molecular modelling studies on the interactions of human DNA topoisomerase IB with pyridoxal-compounds

Biochimie ◽  
2007 ◽  
Vol 89 (4) ◽  
pp. 468-473 ◽  
Author(s):  
Serge Christmann-Franck ◽  
Serge Fermandjian ◽  
Gilles Mirambeau ◽  
P. Arsène Der Garabedian
Keyword(s):  
Molecular Modelling ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Topoisomerase Ib ◽  
Molecular Modelling Studies ◽  
Modelling Studies

Inhibition of human DNA topoisomerase IB by a Cyclometalated Gold III compound: Analysis on the different steps of the enzyme catalytic cycle

2011 ◽  
Vol 516 (2) ◽  
pp. 108-112 ◽  
Author(s):  
Silvia Castelli ◽  
Oscar Vassallo ◽  
Prafulla Katkar ◽  
Chi-Ming Che ◽  
Raymond Wai-Yin Sun ◽  
...  
Keyword(s):  
Catalytic Cycle ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Topoisomerase Ib

Gold(III), Cyclometalated Compound, Inhibition of Human DNA Topoisomerase IB

2013 ◽  
pp. 927-932
Author(s):  
Silvia Castelli ◽  
Oscar Vassallo ◽  
Prafulla Katkar ◽  
Chi-Ming Che ◽  
Raymond Wai-Yin Sun ◽  
...  
Keyword(s):  
Dna Topoisomerase ◽  
Human Dna ◽  
Topoisomerase Ib

Analysis of Bisdioxopiperazine Dexrazoxane Binding to Human DNA Topoisomerase II α:  Decreased Binding as a Mechanism of Drug Resistance†

Biochemistry ◽  
2003 ◽  
Vol 42 (32) ◽  
pp. 9749-9754 ◽  
Author(s):  
Axelle Renodon-Cornière ◽  
Lars H. Jensen ◽  
John L. Nitiss ◽  
Peter B. Jensen ◽  
Maxwell Sehested
Keyword(s):  
Drug Resistance ◽  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Topoisomerase Ii Α
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