scholarly journals PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility

2008 ◽  
Vol 36 (13) ◽  
pp. 4454-4464 ◽  
Author(s):  
C. Godon ◽  
F. P. Cordelieres ◽  
D. Biard ◽  
N. Giocanti ◽  
F. Megnin-Chanet ◽  
...  
Keyword(s):  
Strand Break ◽  
Single Strand ◽  
Parp Inhibition ◽  
Single Strand Break ◽  
Single Strand Break Repair ◽  
Break Repair ◽  
Parp 1

PARP inhibition vs. PARP-1 silencing: different outcomes in terms of single-strand break repair

2008 ◽  
Vol 6 (9) ◽  
pp. 55 ◽  
Author(s):  
C. Godon ◽  
F.P. Cordelieres ◽  
D.S.F. Biard ◽  
F. Megnin-Chanet ◽  
J. Hall ◽  
...  
Keyword(s):  
Strand Break ◽  
Single Strand ◽  
Parp Inhibition ◽  
Single Strand Break ◽  
Single Strand Break Repair ◽  
Break Repair ◽  
Parp 1

scholarly journals Condensin I Interacts with the PARP-1-XRCC1 Complex and Functions in DNA Single-Strand Break Repair

2006 ◽  
Vol 21 (6) ◽  
pp. 837-848 ◽  
Author(s):  
Jason T. Heale ◽  
Alexander R. Ball ◽  
John A. Schmiesing ◽  
Jong-Soo Kim ◽  
Xiangduo Kong ◽  
...  
Keyword(s):  
Strand Break ◽  
Single Strand ◽  
Single Strand Break ◽  
Single Strand Break Repair ◽  
Break Repair ◽  
Parp 1

scholarly journals Poly(ADP-Ribose) Polymerase 1 Accelerates Single-Strand Break Repair in Concert with Poly(ADP-Ribose) Glycohydrolase

2007 ◽  
Vol 27 (15) ◽  
pp. 5597-5605 ◽  
Author(s):  
Anna E. O. Fisher ◽  
Helfrid Hochegger ◽  
Shunichi Takeda ◽  
Keith W. Caldecott
Keyword(s):  
A549 Cells ◽  
Strand Break ◽  
Single Strand ◽  
Single Strand Break ◽  
Single Strand Breaks ◽  
Single Strand Break Repair ◽  
Break Repair ◽  
A Minor ◽  
Parp 1 ◽  
Human A549

ABSTRACT Single-strand breaks are the commonest lesions arising in cells, and defects in their repair are implicated in neurodegenerative disease. One of the earliest events during single-strand break repair (SSBR) is the rapid synthesis of poly(ADP-ribose) (PAR) by poly(ADP-ribose) polymerase (PARP), followed by its rapid degradation by poly(ADP-ribose) glycohydrolase (PARG). While the synthesis of poly(ADP-ribose) is important for rapid rates of chromosomal SSBR, the relative importance of poly(ADP-ribose) polymerase 1 (PARP-1) and PARP-2 and of the subsequent degradation of PAR by PARG is unclear. Here we have quantified SSBR rates in human A549 cells depleted of PARP-1, PARP-2, and PARG, both separately and in combination. We report that whereas PARP-1 is critical for rapid global rates of SSBR in human A549 cells, depletion of PARP-2 has only a minor impact, even in the presence of depleted levels of PARP-1. Moreover, we identify PARG as a novel and critical component of SSBR that accelerates this process in concert with PARP-1.

End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair

FEBS Journal ◽  
2005 ◽  
Vol 272 (22) ◽  
pp. 5753-5763 ◽  
Author(s):  
Jason L. Parsons ◽  
Irina I. Dianova ◽  
Emma Boswell ◽  
Michael Weinfeld ◽  
Grigory L. Dianov
Keyword(s):  
Strand Break ◽  
Single Strand ◽  
Single Strand Break ◽  
X Ray ◽  
Single Strand Break Repair ◽  
Specific Proteins ◽  
Break Repair

scholarly journals Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1

Cell Reports ◽  
2019 ◽  
Vol 26 (3) ◽  
pp. 573-581.e5 ◽  
Author(s):  
Luis M. Polo ◽  
Yingqi Xu ◽  
Peter Hornyak ◽  
Fernando Garces ◽  
Zhihong Zeng ◽  
...  
Keyword(s):  
Strand Break ◽  
Single Strand ◽  
Brct Domain ◽  
Single Strand Break ◽  
Single Strand Break Repair ◽  
Break Repair

scholarly journals TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo

2007 ◽  
Vol 26 (22) ◽  
pp. 4720-4731 ◽  
Author(s):  
Sachin Katyal ◽  
Sherif F El-Khamisy ◽  
Helen R Russell ◽  
Yang Li ◽  
Limei Ju ◽  
...  
Keyword(s):  
Strand Break ◽  
Single Strand ◽  
Single Strand Break ◽  
Single Strand Break Repair ◽  
Break Repair
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