scholarly journals Mitogen-induced recruitment of ERK and MSK to SRE promoter complexes by ternary complex factor Elk-1

2008 ◽  
Vol 36 (8) ◽  
pp. 2594-2607 ◽  
Author(s):  
Hong-Mei Zhang ◽  
Li Li ◽  
Nektaria Papadopoulou ◽  
Glenn Hodgson ◽  
Emma Evans ◽  
...  
Keyword(s):  
Ternary Complex ◽  
Ternary Complex Factor

scholarly journals The ternary complex factor protein ELK1 is an independent prognosticator of disease recurrence in prostate cancer

The Prostate ◽  
2019 ◽  
Vol 80 (2) ◽  
pp. 198-208
Author(s):  
Luke Pardy ◽  
Rayna Rosati ◽  
Claire Soave ◽  
Yanfang Huang ◽  
Seongho Kim ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Ternary Complex ◽  
Disease Recurrence ◽  
Ternary Complex Factor

scholarly journals The ternary complex factor Net contains two distinct elements that mediate different responses to MAP kinase signalling cascades

Oncogene ◽  
2000 ◽  
Vol 19 (44) ◽  
pp. 5063-5072 ◽  
Author(s):  
Catherine Ducret ◽  
Sauveur-Michel Maira ◽  
Yves Lutz ◽  
Bohdan Wasylyk
Keyword(s):  
Map Kinase ◽  
Ternary Complex ◽  
Signalling Cascades ◽  
Ternary Complex Factor

Complexities in ETS-Domain Transcription Factor Function and Regulation: Lessons from the TCF (Ternary Complex Factor) Subfamily

2002 ◽  
Vol 30 (2) ◽  
pp. 1-9 ◽  
Author(s):  
A. D. Sharrocks
Keyword(s):  
Transcription Factor ◽  
Ternary Complex ◽  
Serum Response Factor ◽  
Mitogen Activated Protein Kinase ◽  
Functional Conservation ◽  
Transcriptional Regulatory ◽  
Mitogen Activated Protein ◽  
Ets Domain ◽  
Ternary Complex Factor

The ETS-domain transcription factor family can be divided into a series of subfamilies. Elk-1 represents the founding member of the ternary complex factor (TCF) subfamily. By focusing on the TCF subfamily, we can demonstrate the complexities that exist in the function and regulation of ETS-domain transcription factors. This article focuses on Elk-1 in detail and summarizes the functions of other TCFs. The key themes covered include the domain structure of the TCFs, the mechanisms of complex formation with serum response factor, regulation of TCFs by mitogen-activated protein kinase cascades, and transcriptional regulatory properties of the TCFs. Finally, the emerging role of the TCFs in vivo is discussed. A picture is developing indicating that, while these proteins exhibit significant sequence and functional conservation, key differences in their structure and regulation are being identified which may relate to unique functions of these proteins in vivo.

scholarly journals Cell cycle-regulated transcription of the CLB2 gene is dependent on Mcm1 and a ternary complex factor.

1995 ◽  
Vol 15 (6) ◽  
pp. 3129-3137 ◽  
Author(s):  
M Maher ◽  
F Cong ◽  
D Kindelberger ◽  
K Nasmyth ◽  
S Dalton
Keyword(s):  
Cell Cycle ◽  
Dna Binding ◽  
Cell Cycle Regulation ◽  
Ternary Complex ◽  
Binding Activity ◽  
Transcriptional Level ◽  
Dna Binding Activity ◽  
Cycle Regulation ◽  
Ternary Complex Factor

Clb2 is the major B-type mitotic cyclin required for entry into mitosis in the budding yeast Saccharomyces cerevisiae. We showed that accumulation of CLB2 transcripts in G2 cells is controlled at the transcriptional level and identified a 55-bp upstream activating sequence (UAS) containing an Mcm1 binding site as being necessary and sufficient for cell cycle regulation. Sequences within the cell cycle-regulated UAS were shown to bind Mcm1 in vitro, and mutation which abolished Mcm1-dependent DNA binding activity eliminated cell cycle-regulated transcription in vivo. A second protein with no autonomous DNA binding activity was also recruited into Mcm1-UAS complexes, generating a ternary complex. A point mutation in the CLB2 UAS which blocked ternary complex formation, but still allowed Mcm1 to bind, resulted in loss of cell cycle regulation in vivo, suggesting that the ternary complex factor is also important in control of CLB2 transcription. We discuss the possibility that the CLB2 gene is coregulated with other genes known to be regulated with the same periodicity and suggest that Mcm1 and the ternary complex factor may coordinately regulate several other G2-regulated transcripts.

scholarly journals Ternary Complex Factor-Serum Response Factor Complex-Regulated Gene Activity Is Required for Cellular Proliferation and Inhibition of Apoptotic Cell Death

2004 ◽  
Vol 24 (23) ◽  
pp. 10340-10351 ◽  
Author(s):  
Elaine R. Vickers ◽  
Aneta Kasza ◽  
Isil Aksan Kurnaz ◽  
Anne Seifert ◽  
Leo A. H. Zeef ◽  
...  
Keyword(s):  
Cell Death ◽  
Ternary Complex ◽  
Serum Response Factor ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Gene Activity ◽  
Immediate Early ◽  
Response Factor ◽  
Serum Response ◽  
Ternary Complex Factor

ABSTRACT Members of the ternary complex factor (TCF) subfamily of the ETS-domain transcription factors are activated through phosphorylation by mitogen-activated protein kinases (MAPKs) in response to a variety of mitogenic and stress stimuli. The TCFs bind and activate serum response elements (SREs) in the promoters of target genes in a ternary complex with a second transcription factor, serum response factor (SRF). The association of TCFs with SREs within immediate-early gene promoters is suggestive of a role for the ternary TCF-SRF complex in promoting cell cycle entry and proliferation in response to mitogenic signaling. Here we have investigated the downstream gene regulatory and phenotypic effects of inhibiting the activity of genes regulated by TCFs by expressing a dominantly acting repressive form of the TCF, Elk-1. Inhibition of ternary complex activity leads to the downregulation of several immediate-early genes. Furthermore, blocking TCF-mediated gene expression leads to growth arrest and triggers apoptosis. By using mutant Elk-1 alleles, we demonstrated that these effects are via an SRF-dependent mechanism. The antiapoptotic gene Mcl-1 is identified as a key target for the TCF-SRF complex in this system. Thus, our data confirm a role for TCF-SRF-regulated gene activity in regulating proliferation and provide further evidence to indicate a role in protecting cells from apoptotic cell death.

Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection

2004 ◽  
Vol 5 (3) ◽  
pp. 289-298 ◽  
Author(s):  
Patrick S Costello ◽  
Robert H Nicolas ◽  
Yasuyuki Watanabe ◽  
Ian Rosewell ◽  
Richard Treisman
Keyword(s):  
Positive Selection ◽  
Ternary Complex ◽  
Ternary Complex Factor
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