scholarly journals Use of a multi-thermal washer for DNA microarrays simplifies probe design and gives robust genotyping assays

2007 ◽  
Vol 36 (2) ◽  
pp. e10-e10 ◽  
Author(s):  
Jesper Petersen ◽  
Lena Poulsen ◽  
Sarunas Petronis ◽  
Henrik Birgens ◽  
Martin Dufva
Keyword(s):  
Dna Microarrays ◽  
Probe Design

scholarly journals HiSpOD: probe design for functional DNA microarrays

2011 ◽  
Vol 27 (5) ◽  
pp. 641-648 ◽  
Author(s):  
Eric Dugat-Bony ◽  
Mohieddine Missaoui ◽  
Eric Peyretaillade ◽  
Corinne Biderre-Petit ◽  
Ourdia Bouzid ◽  
...  
Keyword(s):  
Dna Microarrays ◽  
Probe Design ◽  
Functional Dna

scholarly journals Computational Sequence Design Techniques for DNA Microarray Technologies

2013 ◽  
pp. 884-918
Author(s):  
Dan Tulpan ◽  
Athos Ghiggi ◽  
Roberto Montemanni
Keyword(s):  
Dna Microarrays ◽  
Expression Patterns ◽  
Gene Expression Patterns ◽  
Probe Design ◽  
High Quality ◽  
Microarray Probe ◽  
Experimental Performance ◽  
Whole Genomes ◽  
Selection Of ◽  
Design Techniques

In systems biology and biomedical research, microarray technology is a method of choice that enables the complete quantitative and qualitative ascertainment of gene expression patterns for whole genomes. The selection of high quality oligonucleotide sequences that behave consistently across multiple experiments is a key step in the design, fabrication and experimental performance of DNA microarrays. The aim of this chapter is to outline recent algorithmic developments in microarray probe design, evaluate existing probe sequences used in commercial arrays, and suggest methodologies that have the potential to improve on existing design techniques.

scholarly journals Detecting unknown sequences with DNA microarrays: explorative probe design strategies

2011 ◽  
Vol 14 (2) ◽  
pp. 356-371 ◽  
Author(s):  
Eric Dugat-Bony ◽  
Eric Peyretaillade ◽  
Nicolas Parisot ◽  
Corinne Biderre-Petit ◽  
Faouzi Jaziri ◽  
...  
Keyword(s):  
Dna Microarrays ◽  
Probe Design ◽  
Design Strategies

scholarly journals Computational Sequence Design Techniques for DNA Microarray Technologies

2011 ◽  
pp. 57-91 ◽  
Author(s):  
Dan Tulpan ◽  
Athos Ghiggi ◽  
Roberto Montemanni
Keyword(s):  
Dna Microarrays ◽  
Expression Patterns ◽  
Gene Expression Patterns ◽  
Probe Design ◽  
High Quality ◽  
Microarray Probe ◽  
Experimental Performance ◽  
Whole Genomes ◽  
Selection Of ◽  
Design Techniques

In systems biology and biomedical research, microarray technology is a method of choice that enables the complete quantitative and qualitative ascertainment of gene expression patterns for whole genomes. The selection of high quality oligonucleotide sequences that behave consistently across multiple experiments is a key step in the design, fabrication and experimental performance of DNA microarrays. The aim of this chapter is to outline recent algorithmic developments in microarray probe design, evaluate existing probe sequences used in commercial arrays, and suggest methodologies that have the potential to improve on existing design techniques.

Effects of a Supplemental Spanish Phonological Awareness Intervention on Latinx Preschoolers' Dual Language Emergent Literacy Skills

2020 ◽  
Vol 29 (3) ◽  
pp. 1283-1300
Author(s):  
Xigrid T. Soto ◽  
Andres Crucet-Choi ◽  
Howard Goldstein
Keyword(s):  
At Risk ◽  
Phonological Awareness ◽  
Emergent Literacy ◽  
Language Learners ◽  
Literacy Instruction ◽  
Dual Language ◽  
Literacy Skills ◽  
Dual Language Learners ◽  
Probe Design ◽  
Emergent Literacy Skills

Purpose Preschoolers' phonological awareness (PA) and alphabet knowledge (AK) skills are two of the strongest predictors of future reading. Despite evidence that providing at-risk preschoolers with timely emergent literacy interventions can prevent academic difficulties, there is a scarcity of research focusing on Latinx preschoolers who are dual language learners. Despite evidence of benefits of providing Latinxs with Spanish emergent literacy instruction, few studies include preschoolers. This study examined the effects of a supplemental Spanish PA and AK intervention on the dual emergent literacy skills of at-risk Latinx preschoolers. Method A multiple probe design across four units of instruction evaluated the effects of a Spanish supplemental emergent literacy intervention that explicitly facilitated generalizations to English. Four Latinx preschoolers with limited emergent literacy skills in Spanish and English participated in this study. Bilingual researchers delivered scripted lessons targeting PA and AK skills in individual or small groups for 12–17 weeks. Results Children made large gains as each PA skill was introduced into intervention and generalized the PA skills they learned from Spanish to English. They also improved their English initial sound identification skills, a phonemic awareness task, when instruction was delivered in Spanish but with English words. Children made small to moderate gains in their Spanish letter naming and letter–sound correspondence skills and in generalizing this knowledge to English. Conclusion These findings provide preliminary evidence Latinx preschoolers who are dual language learners benefit from emergent literacy instruction that promotes their bilingual and biliterate development.

Anti-Diabetic Activity of a Mineraloid Isolate, in vitro and in Genetically Diabetic Mice

2011 ◽  
Vol 81 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Joel Deneau ◽  
Taufeeq Ahmed ◽  
Roger Blotsky ◽  
Krzysztof Bojanowski
Keyword(s):  
Dna Microarrays ◽  
Human Fibroblasts ◽  
Diabetic Animal ◽  
In Vitro Tests ◽  
Diabetic Mice ◽  
Fossil Material ◽  
Expression Of Genes ◽  
Enhanced Expression ◽  
Genetically Diabetic Mice

Type II diabetes is a metabolic disease mediated through multiple molecular pathways. Here, we report anti-diabetic effect of a standardized isolate from a fossil material - a mineraloid leonardite - in in vitro tests and in genetically diabetic mice. The mineraloid isolate stimulated mitochondrial metabolism in human fibroblasts and this stimulation correlated with enhanced expression of genes coding for mitochondrial proteins such as ATP synthases and ribosomal protein precursors, as measured by DNA microarrays. In the diabetic animal model, consumption of the Totala isolate resulted in decreased weight gain, blood glucose, and glycated hemoglobin. To our best knowledge, this is the first description ever of a fossil material having anti-diabetic activity in pre-clinical models.

Can DNA microarrays change diagnostics and therapy of lung cancer?

2006 ◽  
Vol 54 (S 1) ◽  
Author(s):  
HS Hofmann ◽  
A Simm ◽  
G Hansen ◽  
RJ Scheubel ◽  
RE Silber ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Microarrays ◽  
Diagnostics And Therapy
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