scholarly journals Human sat III and Drosophila hsrω transcripts: a common paradigm for regulation of nuclear RNA processing in stressed cells

2006 ◽  
Vol 34 (19) ◽  
pp. 5508-5514 ◽  
Author(s):  
Caroline Jolly ◽  
Subhash C. Lakhotia
Keyword(s):  
Rna Processing ◽  
Nuclear Rna ◽  
Stressed Cells ◽  
Nuclear Rna Processing

scholarly journals Integrator, a Multiprotein Mediator of Small Nuclear RNA Processing, Associates with the C-Terminal Repeat of RNA Polymerase II

Cell ◽  
2005 ◽  
Vol 123 (2) ◽  
pp. 265-276 ◽  
Author(s):  
David Baillat ◽  
Mohamed-Ali Hakimi ◽  
Anders M. Näär ◽  
Ali Shilatifard ◽  
Neil Cooch ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Rna Processing ◽  
Terminal Repeat ◽  
Small Nuclear Rna ◽  
Nuclear Rna ◽  
Nuclear Rna Processing

Coupling genetics and post-genomic approaches to decipher the cellular splicing code at a systems-wide level

2010 ◽  
Vol 38 (1) ◽  
pp. 237-241 ◽  
Author(s):  
Yilei Liu ◽  
David J. Elliott
Keyword(s):  
Rna Processing ◽  
Binding Proteins ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Eukaryotic Gene Expression ◽  
Nuclear Rna ◽  
Processing Pathways ◽  
Eukaryotic Gene ◽  
Alternatively Spliced ◽  
Nuclear Rna Processing

Nuclear RNA processing is a critical stage in eukaryotic gene expression, and is controlled in part by the expression and concentration of nuclear RNA-binding proteins. Different nuclear RNA-binding proteins are differentially expressed in different cells, helping the spliceosome to decode pre-mRNAs into alternatively spliced mRNAs. Recent post-genomic technology has exposed the complexity of nuclear RNA processing, and is starting to reveal the mechanisms and rules through which networks of RNA-binding proteins can regulate multiple parallel pathways. Identification of multiple parallel processing pathways regulated by nuclear RNA-binding proteins is leading to a systems-wide understanding of the rules and consequences of alternative nuclear RNA processing.

Base-specific ribonucleases potentially involved in heterogeneous nuclear RNA processing and poly(A) metabolism

FEBS Letters ◽  
1984 ◽  
Vol 171 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Michael Bachmann ◽  
Heinz C. Schröder ◽  
Rudolf Messer ◽  
Werner E.G. Müller
Keyword(s):  
Rna Processing ◽  
Nuclear Rna ◽  
Nuclear Rna Processing

scholarly journals A nuclear role for ARGONAUTE-2 in regulation of neuronal alternative polyadenylation

2020 ◽  
Author(s):  
Revital Ravid ◽  
Aviad Siany ◽  
Natalia Rivkin ◽  
Chen Eitan ◽  
Hagai Marmor-Kollet ◽  
...  
Keyword(s):  
Motor Neurons ◽  
Rna Processing ◽  
Alternative Polyadenylation ◽  
Effector Protein ◽  
Argonaute 2 ◽  
Neuronal Nuclei ◽  
Protein Partner ◽  
Cytoplasmic Rna ◽  
Nuclear Rna ◽  
Nuclear Rna Processing

Argonaute 2 (AGO2), the effector protein partner of microRNAs (miRNAs) in the cytoplasmic RNA induced silencing complex, is further involved in nuclear RNA processing. However, a role for AGO2 in regulation of alternative polyadenylation was not yet demonstrated. Here, we reveal unexpected abundance of AGO2 in mouse neuronal nuclei and characterize nuclear AGO2 interactors by mass spectrometry. We discover that AGO2 broadly regulated alternative polyadenylation (APA) in neuronal cells. Specifically, we demonstrate how two isoforms of Ret mRNA, which encodes a receptor tyrosine kinase are regulated by AGO2-depenent APA, affecting downstream GDNF signaling in primary motor neurons.

Nuclear RNA processing

1991 ◽  
Vol 3 (3) ◽  
pp. 493-501 ◽  
Author(s):  
Angus I. Lamond
Keyword(s):  
Rna Processing ◽  
Nuclear Rna ◽  
Nuclear Rna Processing
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