scholarly journals Biochemical characterization and DNA repair pathway interactions of Mag1-mediated base excision repair in Schizosaccharomyces pombe

2005 ◽  
Vol 33 (3) ◽  
pp. 1123-1131 ◽  
Author(s):  
I. Alseth
Keyword(s):  
Dna Repair ◽  
Schizosaccharomyces Pombe ◽  
Base Excision Repair ◽  
Biochemical Characterization ◽  
Excision Repair ◽  
Repair Pathway ◽  
Base Excision

scholarly journals The DNA repair protein NBS1 influences the base excision repair pathway

2009 ◽  
Vol 30 (3) ◽  
pp. 408-415 ◽  
Author(s):  
D. Sagan ◽  
R. Muller ◽  
C. Kroger ◽  
A. Hematulin ◽  
S. Mortl ◽  
...  
Keyword(s):  
Dna Repair ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Repair Pathway ◽  
Base Excision Repair Pathway ◽  
Repair Protein ◽  
Dna Repair Protein ◽  
Base Excision

scholarly journals Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery

FEBS Letters ◽  
1999 ◽  
Vol 450 (3) ◽  
pp. 197-204 ◽  
Author(s):  
Hagai Offer ◽  
Roland Wolkowicz ◽  
Devorah Matas ◽  
Sara Blumenstein ◽  
Zvi Livneh ◽  
...  
Keyword(s):  
Dna Repair ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Repair Pathway ◽  
Base Excision Repair Pathway ◽  
Direct Involvement ◽  
Base Excision

scholarly journals Contribution of Base Excision Repair, Nucleotide Excision Repair, and DNA Recombination to Alkylation Resistance of the Fission Yeast Schizosaccharomyces pombe

2000 ◽  
Vol 182 (8) ◽  
pp. 2104-2112 ◽  
Author(s):  
Asli Memisoglu ◽  
Leona Samson
Keyword(s):  
Dna Repair ◽  
Schizosaccharomyces Pombe ◽  
Nucleotide Excision Repair ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Dna Recombination ◽  
Nucleotide Excision ◽  
Repair Pathways ◽  
Base Excision

ABSTRACT DNA damage is unavoidable, and organisms across the evolutionary spectrum possess DNA repair pathways that are critical for cell viability and genomic stability. To understand the role of base excision repair (BER) in protecting eukaryotic cells against alkylating agents, we generated Schizosaccharomyces pombe strains mutant for the mag1 3-methyladenine DNA glycosylase gene. We report that S. pombe mag1 mutants have only a slightly increased sensitivity to methylation damage, suggesting that Mag1-initiated BER plays a surprisingly minor role in alkylation resistance in this organism. We go on to show that other DNA repair pathways play a larger role than BER in alkylation resistance. Mutations in genes involved in nucleotide excision repair (rad13) and recombinational repair (rhp51) are much more alkylation sensitive thanmag1 mutants. In addition, S. pombe mutant for the flap endonuclease rad2 gene, whose precise function in DNA repair is unclear, were also more alkylation sensitive thanmag1 mutants. Further, mag1 andrad13 interact synergistically for alkylation resistance, and mag1 and rhp51 display a surprisingly complex genetic interaction. A model for the role of BER in the generation of alkylation-induced DNA strand breaks in S. pombe is discussed.

scholarly journals DNA repair in plant mitochondria – a complete base excision repair pathway in potato tuber mitochondria

2018 ◽  
Vol 166 (2) ◽  
pp. 494-512 ◽  
Author(s):  
Beatriz Ferrando ◽  
Ana L.D.M. Furlanetto ◽  
Ricardo Gredilla ◽  
Jesper F. Havelund ◽  
Kim H. Hebelstrup ◽  
...  
Keyword(s):  
Dna Repair ◽  
Potato Tuber ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Plant Mitochondria ◽  
Repair Pathway ◽  
Base Excision Repair Pathway ◽  
Base Excision
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