scholarly journals Solid phase synthesis and binding affinity of peptidyl transferase transition state mimics containing 2'-OH at P-site position A76

2004 ◽  
Vol 32 (4) ◽  
pp. 1502-1511 ◽  
Author(s):  
J. S. Weinger
Keyword(s):  
Transition State ◽  
Binding Affinity ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Peptidyl Transferase ◽  
Phase Synthesis

Solid phase synthesis of phosphinopeptoids as transition state analog inhibitors

1998 ◽  
Vol 39 (21) ◽  
pp. 3375-3378 ◽  
Author(s):  
Peter H. Dorff ◽  
Gordon Chiu ◽  
Steven W. Goldstein ◽  
Bradley P. Morgan
Keyword(s):  
Transition State ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Transition State Analog

Solid-phase synthesis of new pyrrolobenzodiazepine–chalcone conjugates: DNA-binding affinity and anticancer activity

2008 ◽  
Vol 18 (7) ◽  
pp. 2434-2439 ◽  
Author(s):  
Ahmed Kamal ◽  
N. Shankaraiah ◽  
S. Prabhakar ◽  
Ch. Ratna Reddy ◽  
N. Markandeya ◽  
...  
Keyword(s):  
Dna Binding ◽  
Anticancer Activity ◽  
Binding Affinity ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Dna Binding Affinity

scholarly journals Effect of Polymerization Time on the Binding Properties of Ciprofloxacin-Imprinted nanoMIPs Prepared by Solid-Phase Synthesis

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2656
Author(s):  
Matteo Charello ◽  
Laura Anfossi ◽  
Simone Cavalera ◽  
Fabio Di Nardo ◽  
Fiora Artusio ◽  
...  
Keyword(s):  
Binding Affinity ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Polymer Chains ◽  
Polymerization Time ◽  
Dissociation Kinetics ◽  
Binding Properties ◽  
Phase Synthesis ◽  
High Binding ◽  
High Binding Affinity

An innovative approach to imprinted nanoparticles (nanoMIPs) is represented by solid-phase synthesis. Since the polymeric chains grow over time and rearrange themselves around the template, the binding properties of nanoMIPs could depend on the polymerization time. Here we present an explorative study about the effect of different polymerization times on the binding properties of ciprofloxacin-imprinted nanoMIPs. The binding properties towards ciprofloxacin were studied by measuring the binding affinity constants (Keq) and the kinetic rate constants (kd, ka). Furthermore, selectivity and nonspecific binding were valued by measuring the rebinding of levofloxacin onto ciprofloxacin-imprinted nanoMIPs and ciprofloxacin onto diclofenac-imprinted nanoMIPs, respectively. The results show that different polymerization times produce nanoMIPs with different binding properties: short polymerization times (15 min) produced nanoMIPs with high binding affinity but low selectivity (Keq > 107 mol L−1, α ≈ 1); medium polymerization times (30 min–2 h) produced nanoMIPs with high binding affinity and selectivity (Keq ≥ 106 mol L−1, α < 1); and long polymerization times (>2 h) produced nanoMIPs with low binding affinity, fast dissociation kinetics and low selectivity (Keq ≤ 106 mol L−1, kdis > 0.2 min−1, α ≈ 1). The results can be explained as the combined effect of rearrangement and progressive stiffening of the polymer chains around the template molecules.

ChemInform Abstract: Solution-Phase and Solid-Phase Synthesis of Novel Transition State Inhibitors of Coagulation Enzymes Incorporating a Piperidinyl Moiety.

ChemInform ◽  
2010 ◽  
Vol 30 (35) ◽  
pp. no-no
Author(s):  
Anton E. P. Adang ◽  
Co A. M. Peters ◽  
Siene Gerritsma ◽  
Edwin de Zwart ◽  
Gerrit Veeneman
Keyword(s):  
Transition State ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solution Phase ◽  
Phase Synthesis

Solution-phase and solid-phase synthesis of novel transition state inhibitors of coagulation enzymes incorporating a piperidinyl moiety

1999 ◽  
Vol 9 (9) ◽  
pp. 1227-1232 ◽  
Author(s):  
Anton E.P. Adang ◽  
Co A.M. Peters ◽  
Siene Gerritsma ◽  
Edwin de Zwart ◽  
Gerrit Veeneman
Keyword(s):  
Transition State ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solution Phase ◽  
Phase Synthesis
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