scholarly journals Endonucleolytic activation directs dark-induced chloroplast mRNA degradation

2002 ◽  
Vol 30 (20) ◽  
pp. 4527-4533 ◽  
Author(s):  
S. Baginsky
Keyword(s):  
Mrna Degradation ◽  
Chloroplast Mrna

scholarly journals The essential role of mRNA degradation in understanding and engineering E. coli metabolism

2021 ◽  
pp. 107805
Author(s):  
Charlotte Roux ◽  
Thibault Etienne ◽  
Eliane Hajnsdorf ◽  
Delphine Ropers ◽  
A.J. Carpousis ◽  
...  
Keyword(s):  
Essential Role ◽  
Mrna Degradation ◽  
E Coli

scholarly journals Selectivity of mRNA degradation by autophagy in yeast

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Shiho Makino ◽  
Tomoko Kawamata ◽  
Shintaro Iwasaki ◽  
Yoshinori Ohsumi
Keyword(s):  
Ribosomal Proteins ◽  
Rna Degradation ◽  
Mrna Degradation ◽  
Ribosome Profiling ◽  
Genome Wide ◽  
Tightly Coupled ◽  
Response To Stress ◽  
Transcriptional Gene Regulation ◽  
Synthesis And Degradation

AbstractSynthesis and degradation of cellular constituents must be balanced to maintain cellular homeostasis, especially during adaptation to environmental stress. The role of autophagy in the degradation of proteins and organelles is well-characterized. However, autophagy-mediated RNA degradation in response to stress and the potential preference of specific RNAs to undergo autophagy-mediated degradation have not been examined. In this study, we demonstrate selective mRNA degradation by rapamycin-induced autophagy in yeast. Profiling of mRNAs from the vacuole reveals that subsets of mRNAs, such as those encoding amino acid biosynthesis and ribosomal proteins, are preferentially delivered to the vacuole by autophagy for degradation. We also reveal that autophagy-mediated mRNA degradation is tightly coupled with translation by ribosomes. Genome-wide ribosome profiling suggested a high correspondence between ribosome association and targeting to the vacuole. We propose that autophagy-mediated mRNA degradation is a unique and previously-unappreciated function of autophagy that affords post-transcriptional gene regulation.

Hepatoselective Dihydroquinolizinone Bis-acids for HBsAg mRNA Degradation

2021 ◽  
Author(s):  
Nicky Hwang ◽  
Liren Sun ◽  
Daisy Noe ◽  
Patrick Y. S. Lam ◽  
Tianlun Zhou ◽  
...  
Keyword(s):  
Mrna Degradation

scholarly journals Genetic compensation triggered by mutant mRNA degradation

Nature ◽  
2019 ◽  
Vol 568 (7751) ◽  
pp. 193-197 ◽  
Author(s):  
Mohamed A. El-Brolosy ◽  
Zacharias Kontarakis ◽  
Andrea Rossi ◽  
Carsten Kuenne ◽  
Stefan Günther ◽  
...  
Keyword(s):  
Mrna Degradation ◽  
Genetic Compensation

scholarly journals Rhythmic Serotonin N-Acetyltransferase mRNA Degradation Is Essential for the Maintenance of Its Circadian Oscillation

2005 ◽  
Vol 25 (8) ◽  
pp. 3232-3246 ◽  
Author(s):  
Tae-Don Kim ◽  
Jong-So Kim ◽  
Jong Heon Kim ◽  
Jihwan Myung ◽  
Hee-Don Chae ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Expression Patterns ◽  
Mrna Level ◽  
Mrna Degradation ◽  
Circadian Oscillation ◽  
Oscillatory Mechanism ◽  
Key Enzyme ◽  
Mrna Profile ◽  
Species Specific ◽  
Nuclear Ribonucleoprotein

ABSTRACT Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase [AANAT]) is the key enzyme in melatonin synthesis regulated by circadian rhythm. To date, our understanding of the oscillatory mechanism of melatonin has been limited to autoregulatory transcriptional and posttranslational regulations of AANAT mRNA. In this study, we identify three proteins from pineal glands that associate with cis-acting elements within species-specific AANAT 3′ untranslated regions to mediate mRNA degradation. These proteins include heterogeneous nuclear ribonucleoprotein R (hnRNP R), hnRNP Q, and hnRNP L. Their RNA-destabilizing function was determined by RNA interference and overexpression approaches. Expression patterns of these factors in pineal glands display robust circadian rhythm. The enhanced levels detected after midnight correlate with an abrupt decline in AANAT mRNA level. A mathematical model for the AANAT mRNA profile and its experimental evidence with rat pinealocytes indicates that rhythmic AANAT mRNA degradation mediated by hnRNP R, hnRNP Q, and hnRNP L is a key process in the regulation of its circadian oscillation.

Interdependence of translation, transcription and mRNA degradation in the lacZ gene

1992 ◽  
Vol 226 (3) ◽  
pp. 581-596 ◽  
Author(s):  
Oleg Yarchuk ◽  
Nathalie Jacques ◽  
Jean Guillerez ◽  
Marc Dreyfus
Keyword(s):  
Mrna Degradation ◽  
Lacz Gene
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