scholarly journals Defining the minimal length of sequence homology required for selective gene isolation by TAR cloning

2001 ◽  
Vol 29 (6) ◽  
pp. 32e-32 ◽  
Author(s):  
V. N. Noskov
Keyword(s):  
Sequence Homology ◽  
Minimal Length ◽  
Gene Isolation ◽  
Tar Cloning

Minimum space length

2019 ◽  
Author(s):  
Matheus Pereira Lobo
Keyword(s):  
Minimal Length ◽  
Space Length

We follow some logical principles to conclude there is a minimal length.

Solusi Persamaan Schrödinger Berbasis Panjang Minimal untuk Potensial Coulomb Termodifikasi

2018 ◽  
Vol 2 (2) ◽  
pp. 43-47
Author(s):  
A. Suparmi, C. Cari, Ina Nurhidayati
Keyword(s):  
Wave Function ◽  
Quantum Mechanics ◽  
Schrödinger Equation ◽  
Coulomb Potential ◽  
Schrodinger Equation ◽  
Minimal Length ◽  
Energy Spectra ◽  
Atomic Particle ◽  
Approximate Analytical Solutions ◽  
Radial Schrödinger Equation

Abstrak – Persamaan Schrödinger adalah salah satu topik penelitian yang yang paling sering diteliti dalam mekanika kuantum. Pada jurnal ini persamaan Schrödinger berbasis panjang minimal diaplikasikan untuk potensial Coulomb Termodifikasi. Fungsi gelombang dan spektrum energi yang dihasilkan menunjukkan kharakteristik atau tingkah laku dari partikel sub atom. Dengan menggunakan metode pendekatan hipergeometri, diperoleh solusi analitis untuk bagian radial persamaan Schrödinger berbasis panjang minimal diaplikasikan untuk potensial Coulomb Termodifikasi. Hasil yang diperoleh menunjukkan terjadi peningkatan energi yang sebanding dengan meningkatnya parameter panjang minimal dan parameter potensial Coulomb Termodifikasi. Kata kunci: persamaan Schrödinger, panjang minimal, fungsi gelombang, energi, potensial Coulomb Termodifikasi Abstract – The Schrödinger equation is the most popular topic research at quantum mechanics. The  Schrödinger equation based on the concept of minimal length formalism has been obtained for modified Coulomb potential. The wave function and energy spectra were used to describe the characteristic of sub-atomic particle. By using hypergeometry method, we obtained the approximate analytical solutions of the radial Schrödinger equation based on the concept of minimal length formalism for the modified Coulomb potential. The wave function and energy spectra was solved. The result showed that the value of energy increased by the increasing both of minimal length parameter and the potential parameter. Key words: Schrödinger equation, minimal length formalism (MLF), wave function, energy spectra, Modified Coulomb potential

Exosomes: Structure, Biogenesis, Types and Application in Diagnosis and Gene and Drug Delivery

2020 ◽  
Vol 20 (3) ◽  
pp. 195-206 ◽  
Author(s):  
Shriya Agarwal ◽  
Vinayak Agarwal ◽  
Mugdha Agarwal ◽  
Manisha Singh
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Immune Responses ◽  
Biological Membrane ◽  
Gene Isolation ◽  
Delivery Vehicle ◽  
Scientific Communities ◽  
Therapeutic Regime ◽  
Targeted Gene Therapy ◽  
Delivery Mechanism

Abstract: In recent times, several approaches for targeted gene therapy (GT) had been studied. However, the emergence of extracellular vesicles (EVs) as a shuttle carrying genetic information between cells has gained a lot of interest in scientific communities. Owing to their higher capabilities in dealing with short sequences of nucleic acid (mRNA, miRNA), proteins, recombinant proteins, exosomes, the most popular form of EVs are viewed as reliable biological therapeutic conveyers. They have natural access through every biological membrane and can be employed for site-specific and efficient drug delivery without eliciting any immune responses hence, qualifying as an ideal delivery vehicle. Also, there are many research studies conducted in the last few decades on using exosome-mediated gene therapy into developing an effective therapy with the concept of a higher degree of precision in gene isolation, purification and delivery mechanism loading, delivery and targeting protocols. This review discusses several facets that contribute towards developing an efficient therapeutic regime for gene therapy, highlighting limitations and drawbacks associated with current GT and suggested therapeutic regimes.

scholarly journals Novel avian thymic parvalbumin displays high degree of sequence homology to oncomodulin.

1994 ◽  
Vol 269 (7) ◽  
pp. 5288-5296
Author(s):  
R.C. Hapak ◽  
H. Zhao ◽  
J.M. Boschi ◽  
M.T. Henzl
Keyword(s):  
Sequence Homology ◽  
High Degree

scholarly journals The genomic structure of a human chromosome 22 nucleolar organizer region determined by TAR cloning

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jung-Hyun Kim ◽  
Vladimir N. Noskov ◽  
Aleksey Y. Ogurtsov ◽  
Ramaiah Nagaraja ◽  
Nikolai Petrov ◽  
...  
Keyword(s):  
Genomic Structure ◽  
Organizer Region ◽  
Nucleolar Organizer Region ◽  
Nucleolar Organizer ◽  
Chromosome 21 ◽  
Reference Sequence ◽  
Chromosome 22 ◽  
Rdna Variation ◽  
High Level ◽  
Tar Cloning

AbstractThe rDNA clusters and flanking sequences on human chromosomes 13, 14, 15, 21 and 22 represent large gaps in the current genomic assembly. The organization and the degree of divergence of the human rDNA units within an individual nucleolar organizer region (NOR) are only partially known. To address this lacuna, we previously applied transformation-associated recombination (TAR) cloning to isolate individual rDNA units from chromosome 21. That approach revealed an unexpectedly high level of heterogeneity in human rDNA, raising the possibility of corresponding variations in ribosome dynamics. We have now applied the same strategy to analyze an entire rDNA array end-to-end from a copy of chromosome 22. Sequencing of TAR isolates provided the entire NOR sequence, including proximal and distal junctions that may be involved in nucleolar function. Comparison of the newly sequenced rDNAs to reference sequence for chromosomes 22 and 21 revealed variants that are shared in human rDNA in individuals from different ethnic groups, many of them at high frequency. Analysis infers comparable intra- and inter-individual divergence of rDNA units on the same and different chromosomes, supporting the concerted evolution of rDNA units. The results provide a route to investigate further the role of rDNA variation in nucleolar formation and in the empirical associations of nucleoli with pathology.

Sign in / Sign up

Export Citation Format

Share Document