scholarly journals Enhanced activity of an antisense oligonucleotide targeting murine protein kinase C-alpha by the incorporation of 2'-O-propyl modifications

1996 ◽  
Vol 24 (3) ◽  
pp. 411-417 ◽  
Author(s):  
R. McKay
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Antisense Oligonucleotide ◽  
Kinase C ◽  
Enhanced Activity ◽  
Protein Kinase C Alpha

scholarly journals Association of protein kinase-C-alpha with cytoplasmic vesicles in melanoma cells.

1996 ◽  
Vol 44 (2) ◽  
pp. 177-182 ◽  
Author(s):  
J Timar ◽  
B Liu ◽  
R Bazaz ◽  
K V Honn
Keyword(s):  
Plasma Membrane ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Fluid Phase ◽  
Subcellular Fractionation ◽  
Melanoma Cells ◽  
Kinase C ◽  
Cytoplasmic Vesicles ◽  
Protein Kinase C Alpha ◽  
Pkc Alpha

In B16a melanoma cells, protein kinase-C-alpha (PKC alpha) is immunomorphologically associated with cytoplasmic vesicles in addition to the previously observed locations (plasma membrane, cytoskeleton, nucleus), as detected with monoclonal antibody (MAb) MC3a. Subcellular fractionation indicated that the authentic 80-KD protein as well as PKC activity can be detected in several particulate fractions except for L2, which contains dense lysosomes. The highest PKC activity is associated with the cytosol-ultralight vesicles and the L1 fraction (containing plasma membrane, endosomes, and the Golgi apparatus). Both of these fractions contained the fluid-phase endocytosis marker peroxidase, indicating that PKC alpha, in addition to other subcellular structures, is most probably associated with endosomal membranes in B16a melanoma cells.

Protein Kinase C Alpha and Tumorigenesis of the Endocrine Gland

1997 ◽  
Vol 47 (4-6) ◽  
pp. 140-144 ◽  
Author(s):  
Corinne Prévostel ◽  
Annick Martin ◽  
Véronique Alvaro ◽  
Claude Jaffiol ◽  
Dominique Joubert
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Endocrine Gland ◽  
Kinase C ◽  
Protein Kinase C Alpha
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