scholarly journals Isolation and developmental expression of a rat cDNA encoding a cysteine-rich zinc finger protein

1994 ◽  
Vol 22 (24) ◽  
pp. 5477-5483 ◽  
Author(s):  
Colleen R. McLaughlin ◽  
Qing Tao ◽  
Mary E. Abood
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Developmental Expression ◽  
Finger Protein

scholarly journals A Myc-associated zinc finger protein binding site is one of four important functional regions in the CD4 promoter.

1995 ◽  
Vol 15 (6) ◽  
pp. 3179-3186 ◽  
Author(s):  
D D Duncan ◽  
A Stupakoff ◽  
S M Hedrick ◽  
K B Marcu ◽  
G Siu
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Consensus Sequence ◽  
Developmental Expression ◽  
Critical Element ◽  
Factor Binding ◽  
Functional Regions ◽  
Finger Protein ◽  
Myc Gene ◽  
Predominant Factor

The CD4 promoter plays an important role in the developmental control of CD4 transcription. In this report, we show that the minimal CD4 promoter has four factor binding sites, each of which is required for full function. Using biochemical and mutagenesis analyses, we determined that multiple nuclear factors bind to these independent sites. We determined that an initiator-like sequence present at the cap site and an Ets consensus sequence are required for full promoter function. We also demonstrate that the Myc-associated zinc finger protein (MAZ) appears to be the predominant factor binding to one of these sites. This last site closely resembles the ME1a1 G3AG4AG3 motif previously shown to be a critical element in the P2 promoter of the c-myc gene. We therefore believe that the MAZ transcription factor is also likely to play an important role in the control of developmental expression of the CD4 gene.

Developmental expression of the Zinc-finger protein in

1990 ◽  
Vol 14 ◽  
pp. 58
Author(s):  
F RIJLI ◽  
S DELUCCHINI ◽  
C IGNACCHITI ◽  
F GRANUCCI ◽  
G CILIBERTO ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Developmental Expression ◽  
Finger Protein
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