scholarly journals Parallel-stranded duplex DNA containing blocks of trans purine-purine and purine-pyrimidine base pairs

1994 ◽  
Vol 22 (16) ◽  
pp. 3293-3303 ◽  
Author(s):  
Elisabeth M. Evertsz ◽  
Karsten Rippe ◽  
Thomas M. Jovin
Keyword(s):  
Duplex Dna ◽  
Base Pairs ◽  
Pyrimidine Base ◽  
Purine Pyrimidine

scholarly journals Abiotic synthesis of purine and pyrimidine ribonucleosides in aqueous microdroplets

2017 ◽  
Vol 115 (1) ◽  
pp. 36-40 ◽  
Author(s):  
Inho Nam ◽  
Hong Gil Nam ◽  
Richard N. Zare
Keyword(s):  
Aqueous Solution ◽  
Mass Spectra ◽  
Room Temperature ◽  
Flight Time ◽  
Magnesium Ion ◽  
Base Pairs ◽  
Pyrimidine Base ◽  
Mild Conditions ◽  
Letter Alphabet ◽  
Purine Pyrimidine

Aqueous microdroplets (<1.3 µm in diameter on average) containing 15 mM d-ribose, 15 mM phosphoric acid, and 5 mM of a nucleobase (uracil, adenine, cytosine, or hypoxanthine) are electrosprayed from a capillary at +5 kV into a mass spectrometer at room temperature and 1 atm pressure with 3 mM divalent magnesium ion (Mg2+) as a catalyst. Mass spectra show the formation of ribonucleosides that comprise a four-letter alphabet of RNA with a yield of 2.5% of uridine (U), 2.5% of adenosine (A), 0.7% of cytidine (C), and 1.7% of inosine (I) during the flight time of ∼50 µs. In the case of uridine, no catalyst is required. An aqueous solution containing guanine cannot be generated under the same conditions given the extreme insolubility of guanine in water. However, inosine can base pair with cytidine and thus substitute for guanosine. Thus, a full set of ribonucleosides to generate the purine–pyrimidine base pairs A-U and I-C are spontaneously generated in aqueous microdroplets under similar mild conditions.

scholarly journals Transient Hoogsteen base pairs in canonical duplex DNA

Nature ◽  
2011 ◽  
Vol 470 (7335) ◽  
pp. 498-502 ◽  
Author(s):  
Evgenia N. Nikolova ◽  
Eunae Kim ◽  
Abigail A. Wise ◽  
Patrick J. O’Brien ◽  
Ioan Andricioaei ◽  
...  
Keyword(s):  
Duplex Dna ◽  
Base Pairs

scholarly journals A historical account of hoogsteen base-pairs in duplex DNA

Biopolymers ◽  
2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
Evgenia N. Nikolova ◽  
Huiqing Zhou ◽  
Federico L. Gottardo ◽  
Heidi S. Alvey ◽  
Isaac J. Kimsey ◽  
...  
Keyword(s):  
Duplex Dna ◽  
Historical Account ◽  
Base Pairs
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