scholarly journals Use of alternative polyadenylation sites for tissue-specific transcription of two angiotensin-converting enzyme mRNAs

1992 ◽  
Vol 20 (4) ◽  
pp. 683-687 ◽  
Author(s):  
Thomas J. Thekkumkara ◽  
William Livingston ◽  
Ravi S. Kumar ◽  
Ganes C. Sen
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Alternative Polyadenylation ◽  
Converting Enzyme ◽  
Tissue Specific ◽  
Polyadenylation Sites

Calcitonin/calcitonin gene-related peptide transcription unit: tissue-specific expression involves selective use of alternative polyadenylation sites

1984 ◽  
Vol 4 (10) ◽  
pp. 2151-2160
Author(s):  
S G Amara ◽  
R M Evans ◽  
M G Rosenfeld
Keyword(s):  
Regulation Of Gene Expression ◽  
Alternative Polyadenylation ◽  
Calcitonin Gene Related Peptide ◽  
Transcription Unit ◽  
Specific Expression ◽  
Tissue Specific ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Polyadenylation Sites ◽  
Specific Regulation

Different 3' coding exons in the rat calcitonin gene are used to generate distinct mRNAs encoding either the hormone calcitonin in thyroidal C-cells or a new neuropeptide referred to as calcitonin gene-related peptide in neuronal tissue, indicating the RNA processing regulation is one strategy used in tissue-specific regulation of gene expression in the brain. Although the two mRNAs use the same transcriptional initiation site and have identical 5' terminal sequences, their 3' termini are distinct. The polyadenylation sites for calcitonin and calcitonin gene-related peptide mRNAs are located at the end of the exons 4 and 6, respectively. Termination of transcription after the calcitonin exon does not dictate the production of calcitonin mRNA, because transcription proceeds through both calcitonin and calcitonin gene-related peptide exons irrespective of which mRNA is ultimately produced. In isolated nuclei, both polyadenylation sites appear to be utilized; however, the proximal (calcitonin) site is preferentially used in nuclei from tissues producing calcitonin mRNA. These data suggest that the mechanism dictating production of each mRNA involves the selective use of alternative polyadenylation sites.

Tissue Specific Expression of Angiotensin Converting Enzyme

1992 ◽  
pp. 376-383
Author(s):  
K. E. Bernstein ◽  
T. E. Howard ◽  
S-Y. Shai ◽  
K. G. Langford ◽  
R. Balogh
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression

scholarly journals TSAPA: identification of tissue-specific alternative polyadenylation sites in plants

2018 ◽  
Vol 34 (12) ◽  
pp. 2123-2125 ◽  
Author(s):  
Guoli Ji ◽  
Moliang Chen ◽  
Wenbin Ye ◽  
Sheng Zhu ◽  
Congting Ye ◽  
...  
Keyword(s):  
Alternative Polyadenylation ◽  
Tissue Specific ◽  
Specific Alternative ◽  
Polyadenylation Sites

scholarly journals Obesity Is Associated With Tissue-Specific Activation of Renal Angiotensin-Converting Enzyme In Vivo

Hypertension ◽  
2000 ◽  
Vol 35 (1) ◽  
pp. 329-336 ◽  
Author(s):  
Matthias Barton ◽  
Renata Carmona ◽  
Henning Morawietz ◽  
Livius V. d’Uscio ◽  
Winfried Goettsch ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Tissue Specific

Tissue-specific modulation of angiotensin-converting enzyme (ACE) in hyperthyroidism

Peptides ◽  
2006 ◽  
Vol 27 (11) ◽  
pp. 2942-2949 ◽  
Author(s):  
M.S. Carneiro-Ramos ◽  
V.B. Silva ◽  
R.A.S. Santos ◽  
M.L.M. Barreto-Chaves
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Tissue Specific

scholarly journals Angiotensin-Converting Enzyme 2 (ACE2) and ACE Activities Display Tissue-Specific Sensitivity to Undernutrition-Programmed Hypertension in the Adult Rat

Hypertension ◽  
2005 ◽  
Vol 46 (5) ◽  
pp. 1169-1174 ◽  
Author(s):  
Guillaume Rivière ◽  
Annie Michaud ◽  
Christophe Breton ◽  
Gilles VanCamp ◽  
Christine Laborie ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Tissue Specific ◽  
Angiotensin Converting Enzyme 2 ◽  
Adult Rat ◽  
Specific Sensitivity

scholarly journals Calcitonin/calcitonin gene-related peptide transcription unit: tissue-specific expression involves selective use of alternative polyadenylation sites.

1984 ◽  
Vol 4 (10) ◽  
pp. 2151-2160 ◽  
Author(s):  
S G Amara ◽  
R M Evans ◽  
M G Rosenfeld
Keyword(s):  
Regulation Of Gene Expression ◽  
Alternative Polyadenylation ◽  
Calcitonin Gene Related Peptide ◽  
Transcription Unit ◽  
Specific Expression ◽  
Tissue Specific ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Polyadenylation Sites ◽  
Specific Regulation

Different 3' coding exons in the rat calcitonin gene are used to generate distinct mRNAs encoding either the hormone calcitonin in thyroidal C-cells or a new neuropeptide referred to as calcitonin gene-related peptide in neuronal tissue, indicating the RNA processing regulation is one strategy used in tissue-specific regulation of gene expression in the brain. Although the two mRNAs use the same transcriptional initiation site and have identical 5' terminal sequences, their 3' termini are distinct. The polyadenylation sites for calcitonin and calcitonin gene-related peptide mRNAs are located at the end of the exons 4 and 6, respectively. Termination of transcription after the calcitonin exon does not dictate the production of calcitonin mRNA, because transcription proceeds through both calcitonin and calcitonin gene-related peptide exons irrespective of which mRNA is ultimately produced. In isolated nuclei, both polyadenylation sites appear to be utilized; however, the proximal (calcitonin) site is preferentially used in nuclei from tissues producing calcitonin mRNA. These data suggest that the mechanism dictating production of each mRNA involves the selective use of alternative polyadenylation sites.

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