scholarly journals Cell cycle dependent cellular uptake of zinc oxide nanoparticles in human epidermal cells

Mutagenesis ◽  
2016 ◽  
Vol 31 (4) ◽  
pp. 481-490 ◽  
Author(s):  
Pal Patel ◽  
Krupa Kansara ◽  
Violet Aileen Senapati ◽  
Rishi Shanker ◽  
Alok Dhawan ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Zinc Oxide ◽  
Cellular Uptake ◽  
Zinc Oxide Nanoparticles ◽  
Epidermal Cells ◽  
Oxide Nanoparticles ◽  
Human Epidermal Cells ◽  
Cycle Dependent

DNA damaging potential of zinc oxide nanoparticles in human epidermal cells

2009 ◽  
Vol 185 (3) ◽  
pp. 211-218 ◽  
Author(s):  
Vyom Sharma ◽  
Ritesh K. Shukla ◽  
Neha Saxena ◽  
Devendra Parmar ◽  
Mukul Das ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Epidermal Cells ◽  
Oxide Nanoparticles ◽  
Human Epidermal Cells

Zinc oxide nanoparticles induced gene mutation at the HGPRT locus and cell cycle arrest associated with apoptosis in V‐79 cells

2019 ◽  
Vol 39 (5) ◽  
pp. 735-750 ◽  
Author(s):  
Abhishek Kumar Jain ◽  
Divya Singh ◽  
Kavita Dubey ◽  
Renuka Maurya ◽  
Alok Kumar Pandey
Keyword(s):  
Cell Cycle ◽  
Zinc Oxide ◽  
Cell Cycle Arrest ◽  
Gene Mutation ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Cycle Arrest

scholarly journals Zinc Oxide Nanoparticles Can Intervene in Radiation-Induced Senescence and Eradicate Residual Tumor Cells

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2989
Author(s):  
Nadine Wiesmann ◽  
Rita Gieringer ◽  
Melanie Viel ◽  
Jonas Eckrich ◽  
Wolfgang Tremel ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Zinc Oxide ◽  
Tumor Cells ◽  
Zinc Oxide Nanoparticles ◽  
Tumor Therapy ◽  
Cell Mass ◽  
The Body ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
Radiation Induced

Despite recent advancements in tumor therapy, metastasis and tumor relapse remain major complications hindering the complete recovery of many cancer patients. Dormant tumor cells, which reside in the body, possess the ability to re-enter the cell cycle after therapy. This phenomenon has been attributed to therapy-induced senescence. We show that these cells could be targeted by the use of zinc oxide nanoparticles (ZnO NPs). In the present study, the properties of tumor cells after survival of 16 Gy gamma-irradiation were investigated in detail. Analysis of morphological features, proliferation, cell cycle distribution, and protein expression revealed classical hallmarks of senescent cells among the remnant cell mass after irradiation. The observed radiation-induced senescence was associated with the increased ability to withstand further irradiation. Additionally, tumor cells were able to re-enter the cell cycle and proliferate again after weeks. Treatment with ZnO NPs was evaluated as a therapeutical approach to target senescent cells. ZnO NPs were suitable to induce cell death in senescent, irradiation-resistant tumor cells. Our findings underline the pathophysiological relevance of remnant tumor cells that survived first-line radiotherapy. Additionally, we highlight the therapeutic potential of ZnO NPs for targeting senescent tumor cells.

scholarly journals Cellular Uptake and Toxicological Effects of Differently Sized Zinc Oxide Nanoparticles in Intestinal Cells

Toxics ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 96
Author(s):  
Anna Mittag ◽  
Christian Hoera ◽  
Alexander Kämpfe ◽  
Martin Westermann ◽  
Jochen Kuckelkorn ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Cell Lines ◽  
Cellular Uptake ◽  
Zinc Oxide Nanoparticles ◽  
Food Packaging ◽  
Food Additives ◽  
Intestinal Cell ◽  
Oral Exposure ◽  
Oxide Nanoparticles ◽  
Toxicological Effects

Due to their beneficial properties, the use of zinc oxide nanoparticles (ZnO NP) is constantly increasing, especially in consumer-related areas, such as food packaging and food additives, which is leading to an increased oral uptake of ZnO NP. Consequently, the aim of our study was to investigate the cellular uptake of two differently sized ZnO NP (<50 nm and <100 nm; 12–1229 µmol/L) using two human intestinal cell lines (Caco-2 and LT97) and to examine the possible resulting toxic effects. ZnO NP (<50 nm and <100 nm) were internalized by both cell lines and led to intracellular changes. Both ZnO NP caused time- and dose-dependent cytotoxic effects, especially at concentrations of 614 µmol/L and 1229 µmol/L, which was associated with an increased rate of apoptotic and dead cells. ZnO NP < 100 nm altered the cell cycle of LT97 cells but not that of Caco-2 cells. ZnO NP < 50 nm led to the formation of micronuclei in LT97 cells. The Ames test revealed no mutagenicity for both ZnO NP. Our results indicate the potential toxicity of ZnO NP after oral exposure, which should be considered before application.

scholarly journals Eco-Friendly Formulated Zinc Oxide Nanoparticles: Induction of Cell Cycle Arrest and Apoptosis in the MCF-7 Cancer Cell Line

Genes ◽  
2017 ◽  
Vol 8 (10) ◽  
pp. 281 ◽  
Author(s):  
Amin Boroumand Moghaddam ◽  
Mona Moniri ◽  
Susan Azizi ◽  
Raha Abdul Rahim ◽  
Arbakariya Bin Ariff ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Zinc Oxide ◽  
Cell Cycle Arrest ◽  
Cell Line ◽  
Cancer Cell ◽  
Zinc Oxide Nanoparticles ◽  
Cancer Cell Line ◽  
Oxide Nanoparticles ◽  
Cycle Arrest ◽  
Mcf 7

Optical Characteristics of Zinc Oxide Nanoparticles with Surface Modification Using Polyethylene Glycol

2014 ◽  
Vol 29 (10) ◽  
pp. 1039
Author(s):  
TAN Man-Lin ◽  
WANG Yan-Tao ◽  
ZHANG Wei-Li ◽  
FU Dong-Ju ◽  
LI Dong-Shuang ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Surface Modification ◽  
Polyethylene Glycol ◽  
Zinc Oxide Nanoparticles ◽  
Optical Characteristics ◽  
Oxide Nanoparticles

A comparative study of the antibacterial activity of Quercus robur (Ethanolic extract) and Zinc oxide nanoparticles on Salmonella (In vitro)

2018 ◽  
Vol 9 (SPL1) ◽  
Author(s):  
Hams H. H. Alfattli ◽  
Ghufran Zuhair Jiber ◽  
Ghaidaa Gatea Abbass
Keyword(s):  
Zinc Oxide ◽  
Antibacterial Activity ◽  
Zinc Oxide Nanoparticles ◽  
Quercus Robur ◽  
Ethanolic Extract ◽  
Inhibitory Effect ◽  
Significant Inhibition ◽  
Oxide Nanoparticles ◽  
Inhibition Zones

This study which designed to evaluate the inhibitory effect of Ethanolic extract of (Quercusrobur) and Zinc oxide nanoparticles on the growth of one genus of enterobacteriacae (Salmonella). In vitro. For this purpose graduate concentrates for plant extract (50, 100, 200, 400 )mg/ml which prepared and compared with Zinc oxide nanoparticles of different concentration (2, 1, 0.5, 0.25) μg/ml,and examined. The result showed that the studied medicinal plant has antibacterial activity against this bacteria which used. The result showed that the plant has good activity in decrease the growth of this bacteria. The results of the study also showed that the nano-ZnO has very effective antibacterial action against the studied bacteria which was Salmonella,nanoparticles concentrations lead to increasing in the inhibition zones of tested bacterial growth. We also study the effect of three antibiotics Lomefloxacin (LOM), Ciprofloxacin (SIP) and Rifampin (RA) and the result showed,in a comparison within the tested bacteria,Salmonella had a significant inhibition increase in Lomefloxacin ; the ciprofloxacin showed effect on tested bacteria. However,Rifampin does not show any effect on tested bacteria.

Sign in / Sign up

Export Citation Format

Share Document