scholarly journals Differences in nucleotide excision repair capacity between newly diagnosed colorectal cancer patients and healthy controls

Mutagenesis ◽  
2012 ◽  
Vol 27 (4) ◽  
pp. 519-522 ◽  
Author(s):  
J. Slyskova ◽  
A. Naccarati ◽  
B. Pardini ◽  
V. Polakova ◽  
L. Vodickova ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Healthy Controls ◽  
Newly Diagnosed ◽  
Repair Capacity ◽  
Nucleotide Excision ◽  
Colorectal Cancer Patients

scholarly journals Differences in nucleotide excision repair capacity between newly diagnosed colorectal cancer patients and healthy controls

Mutagenesis ◽  
2012 ◽  
Vol 27 (2) ◽  
pp. 225-232 ◽  
Author(s):  
Jana Slyskova ◽  
Alessio Naccarati ◽  
Barbara Pardini ◽  
Veronika Polakova ◽  
Ludmila Vodickova ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Healthy Controls ◽  
Newly Diagnosed ◽  
Repair Capacity ◽  
Nucleotide Excision ◽  
Colorectal Cancer Patients

Nucleotide Excision Repair Capacity and XPC and XPD Gene Polymorphism Modulate Colorectal Cancer Risk

2018 ◽  
Vol 17 (2) ◽  
pp. e435-e441 ◽  
Author(s):  
Bartosz Mucha ◽  
Dariusz Pytel ◽  
Lukasz Markiewicz ◽  
Magda Cuchra ◽  
Izabela Szymczak ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Gene Polymorphism ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Colorectal Cancer Risk ◽  
Repair Capacity ◽  
Nucleotide Excision

scholarly journals Unmet Need for Symptom Management in a Newly Diagnosed Population of Lung and Colorectal Cancer Patients (412-C)

2012 ◽  
Vol 43 (2) ◽  
pp. 377-378
Author(s):  
Anne Walling ◽  
Jane Weeks ◽  
Katherine Kahn ◽  
Diana Tisnado ◽  
Nancy Keating ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Symptom Management ◽  
Unmet Need ◽  
Newly Diagnosed ◽  
Colorectal Cancer Patients

Whole body MRI is effective for identifying metastatic disease in colorectal cancer patients

BMJ ◽  
2019 ◽  
pp. l5453
Author(s):  
Rob Cook ◽  
Peter Davidson ◽  
Rosie Martin
Keyword(s):  
Colorectal Cancer ◽  
Diagnostic Accuracy ◽  
Cancer Patients ◽  
Metastatic Disease ◽  
Health Technology ◽  
Whole Body ◽  
Newly Diagnosed ◽  
Whole Body Mri ◽  
Health Technology Assessment Programme ◽  
Colorectal Cancer Patients

The studyTaylor S, Mallett S, Beare S et al. Diagnostic accuracy of whole-body MRI versus standard imaging pathways for metastatic disease in newly diagnosed colorectal cancer: the prospective Streamline C trial. Lancet Gastroenterol Hepatol 2019;4:529-37.This project was funded by the NIHR Health Technology Assessment Programme (project number 10/68/01).To read the full NIHR Signal, go to https://discover.dc.nihr.ac.uk/content/signal-000797/identifying-metastatic-disease-in-colorectal-cancer-with-whole-body-mri

Association between pretreatment Fusobacterium nucleatum and cancer pain at six months postsurgery in newly diagnosed colorectal cancer patients: Results from the ColoCare Study.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 3581-3581
Author(s):  
Anita Roselyn Peoples ◽  
Biljana Gigic ◽  
Jennifer Ose ◽  
Andreana Natalie Holowatyj ◽  
Patrick M. Mallea ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Pain ◽  
Cancer Patients ◽  
Fusobacterium Nucleatum ◽  
Tumor Stage ◽  
Life Questionnaire ◽  
Newly Diagnosed ◽  
European Organization ◽  
Post Surgery ◽  
Colorectal Cancer Patients

3581 Background: Pain is a prevalent, debilitating symptom in more than half of cancer patients. Accumulating evidence suggests a bi-directional relationship between gut microbiota and pain, potentially via inflammation and oxidative stress. Fusobacterium nucleatum (Fn), a pro-inflammatory anaerobic bacterium, is frequently detected in colorectal cancer (CRC) patients. To date, no study has identified a relationship between Fn and cancer pain in CRC patients. We investigated the associations between pre-treatment Fn and cancer pain at 6 months post-surgery in CRC patients. Methods: We utilized pre-surgery stool samples collected from 80 prospectively followed, newly diagnosed CRC patients recruited from the German site of the international ColoCare Study. Eligible patients were neo-adjuvant treatment naïve and did not use antibiotics for at least 1 month before stool collection. Fn DNA was assessed via quantitative real-time polymerase chain reaction. Patients were median split into Fn-high (>17.27; n=40) or Fn-low (≤17.27; n=40). Cancer pain was assessed using the 2 pain symptom items from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core-30 (lower score=lower pain) at pre- and 6 months post-surgery. Results: Before surgery, 48% of all patients reported any pain. At 6 months post-surgery, we observed a decrease in cancer pain by 33% for Fn-low, while there was an increase in cancer pain by 41% for Fn-high. After controlling for pre-surgery cancer pain in ANCOVA model, we observed significantly higher mean cancer pain at 6 months post-surgery in the Fn-high group vs. the Fn-low group (24.07 vs. 13.44; effect size, ES=0.45; p=0.04). These results were maintained even after controlling for age, sex, tumor stage and site, adjuvant chemotherapy, BMI, physical activity, and any pain medications (29.11 vs. 16.55; ES=0.53; p=0.03). Conclusions: These findings suggest that high Fn is an independent predictor of cancer pain at 6 months post-surgery in colorectal cancer patients. Further research is needed to confirm and understand the mechanisms of these results. Funding: NCI U01 CA206110.

scholarly journals DNA damage and nucleotide excision repair capacity in healthy individuals

2011 ◽  
Vol 52 (7) ◽  
pp. 511-517 ◽  
Author(s):  
Jana Slyskova ◽  
Alessio Naccarati ◽  
Veronika Polakova ◽  
Barbara Pardini ◽  
Ludmila Vodickova ◽  
...  
Keyword(s):  
Dna Damage ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Healthy Individuals ◽  
Repair Capacity ◽  
Nucleotide Excision

scholarly journals Nucleotide Excision Repair or Polymerase V-Mediated Lesion Bypass Can Act To Restore UV-Arrested Replication Forks in Escherichia coli

2005 ◽  
Vol 187 (20) ◽  
pp. 6953-6961 ◽  
Author(s):  
Charmain T. Courcelle ◽  
Jerilyn J. Belle ◽  
Justin Courcelle
Keyword(s):  
Dna Synthesis ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Translesion Synthesis ◽  
Replication Forks ◽  
Repair Capacity ◽  
Translesion Dna Synthesis ◽  
Pol V ◽  
Nucleotide Excision ◽  
Translesion Dna

ABSTRACT Nucleotide excision repair and translesion DNA synthesis are two processes that operate at arrested replication forks to reduce the frequency of recombination and promote cell survival following UV-induced DNA damage. While nucleotide excision repair is generally considered to be error free, translesion synthesis can result in mutations, making it important to identify the order and conditions that determine when each process is recruited to the arrested fork. We show here that at early times following UV irradiation, the recovery of DNA synthesis occurs through nucleotide excision repair of the lesion. In the absence of repair or when the repair capacity of the cell has been exceeded, translesion synthesis by polymerase V (Pol V) allows DNA synthesis to resume and is required to protect the arrested replication fork from degradation. Pol II and Pol IV do not contribute detectably to survival, mutagenesis, or restoration of DNA synthesis, suggesting that, in vivo, these polymerases are not functionally redundant with Pol V at UV-induced lesions. We discuss a model in which cells first use DNA repair to process replication-arresting UV lesions before resorting to mutagenic pathways such as translesion DNA synthesis to bypass these impediments to replication progression.

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