scholarly journals Gene expression variations: potentialities of master regulator polymorphisms in colorectal cancer risk

Mutagenesis ◽  
2012 ◽  
Vol 27 (2) ◽  
pp. 161-167 ◽  
Author(s):  
B. Pardini ◽  
A. Naccarati ◽  
P. Vodicka ◽  
R. Kumar
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Cancer Risk ◽  
Colorectal Cancer Risk ◽  
Master Regulator

scholarly journals Interactions Between Folate Intake and Genetic Predictors of Gene Expression Levels Associated with Colorectal Cancer Risk

2021 ◽  
Author(s):  
Cameron B. Haas ◽  
Yu-Ru Su ◽  
Paneen Petersen ◽  
Xiaoliang Wang ◽  
Stephanie A Bien ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Cancer Risk ◽  
Colorectal Cancer Risk ◽  
Cellular Damage ◽  
Folate Intake ◽  
European Ancestry ◽  
Specific Gene ◽  
Case Control Studies ◽  
Colon Tissue

Abstract Background Observational studies have shown higher folate consumption to be associated with lower risk of colorectal cancer (CRC). Understanding whether and how genetic risk factors interact with folate could further elucidate the underlying mechanism. Aggregating functionally relevant genetic variants in set-based variant testing has higher power to detect gene-environment (GxE) interactions and may provide information on the underlying biological pathway. Objective We investigated interactions between folate consumption and predicted gene expression on colorectal cancer risk across the genome. Methods We used variant weights from the PrediXcan models of colon tissue-specific gene expression as a priori variant information for a set-based GxE approach. We harmonized total folate intake (mcg/day) based on dietary intake and supplemental use across cohort and case-control studies and calculated sex and study specific quantiles. Analyses were performed using a mixed effects score tests for interactions between folate and genetically predicted expression of 4,839 genes with available genetically predicted expression. We meta-analyzed results across 23 studies for a total of 13,498 cases with colorectal tumors and 13,918 controls of European ancestry. Results We found suggestive evidence of interaction with folate intake for genes including glutathione S-Transferase Alpha 1 (GSTA1; p=4.3E-4), Tonsuko Like, DNA Repair Protein (TONSL; p=4.3E-4), and Aspartylglucosaminidase (AGA: p=4.5E-4). Glutathione is an antioxidant, preventing cellular damage and is a downstream metabolite of homocysteine and metabolized by GSTA1. TONSL is part of a complex that functions in the recovery of double strand breaks and AGA plays a role in lysosomal breakdown of glycoprotein. Conclusion We identified three genes involved in preventing or repairing DNA damage that may interact with folate consumption to alter CRC risk.

scholarly journals Differential genetic influences over colorectal cancer risk and gene expression in large bowel mucosa

2021 ◽  
Author(s):  
Peter. G. Vaughan‐Shaw ◽  
Maria Timofeeva ◽  
Li‐Yin Ooi ◽  
Victoria Svinti ◽  
Graeme Grimes ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Cancer Risk ◽  
Large Bowel ◽  
Colorectal Cancer Risk ◽  
Genetic Influences ◽  
Bowel Mucosa

scholarly journals Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort

2020 ◽  
Author(s):  
Joseph A. Rothwell ◽  
Neil Murphy ◽  
Jelena Bešević ◽  
Nathalie Kliemann ◽  
Mazda Jenab ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Healthy Lifestyle ◽  
Colorectal Cancer Risk ◽  
Lifestyle Patterns ◽  
Metabolic Signatures
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