scholarly journals Environmental lead exposure increases micronuclei in children

Mutagenesis ◽  
2007 ◽  
Vol 22 (3) ◽  
pp. 201-207 ◽  
Author(s):  
L. Kapka ◽  
A. Baumgartner ◽  
E. Siwinska ◽  
L. E. Knudsen ◽  
D. Anderson ◽  
...  
Keyword(s):  
Lead Exposure ◽  
Environmental Lead ◽  
Environmental Lead Exposure

scholarly journals LOW-LEVEL ENVIRONMENTAL LEAD EXPOSURE IN CHILDHOOD AND ADULT INTELLECTUAL FUNCTION: A FOLLOW -UP STUDY

2011 ◽  
Vol 2011 (1) ◽  
Author(s):  
Maitreyi Mazumdar ◽  
David Bellinger ◽  
Matthew Gregas ◽  
Kathleen Abanilla ◽  
Janine Bacic ◽  
...  
Keyword(s):  
Lead Exposure ◽  
Low Level ◽  
Environmental Lead ◽  
Follow Up Study ◽  
Intellectual Function ◽  
Environmental Lead Exposure

High Lead Exposure Associated With Higher Blood Pressure in Haiti: a Warning Sign for Low-Income Countries

Hypertension ◽  
2021 ◽  
Author(s):  
Lily D. Yan ◽  
Vanessa Rouzier ◽  
Jean Lookens Pierre ◽  
Myung Hee Lee ◽  
Paul Muntner ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Lead Exposure ◽  
Lead Level ◽  
Blood Lead ◽  
Lower Income ◽  
Environmental Lead ◽  
Lead Levels ◽  
Environmental Lead Exposure ◽  
Lower Income Countries

Cardiovascular disease is the leading cause of death in lower-income countries including Haiti. Environmental lead exposure is associated with high blood pressure and cardiovascular mortality in high-income countries but has not been systematically measured and evaluated as a potential modifiable cardiovascular risk factor in lower-income countries where 6.5 billion people reside. We hypothesized lead exposure is high in urban Haiti and associated with higher blood pressure levels. Blood lead levels were measured in 2504 participants ≥18 years enrolled in a longitudinal population-based cohort study in Port-au-Prince. Lead screening was conducted using LeadCare II (detection limit ≥3.3 µg/dL). Levels below detection were imputed by dividing the level of detection by √2. Associations between lead (quartiles) and systolic blood pressure and diastolic blood pressure were assessed, adjusting for age, sex, obesity, smoking, alcohol, physical activity, income, and antihypertensive medication use. The median age of participants was 40 years and 60.1% were female. The geometric mean blood lead level was 4.73µg/dL, 71.1% had a detectable lead level and 42.3% had a blood lead level ≥5 µg/dL. After multivariable adjustment, lead levels in quartile four (≥6.5 µg/dL) compared with quartile 1 (<3.4 µg/dL) were associated with 2.42 mm Hg (95% CI, 0.36–4.49) higher systolic blood pressure and 1.96 mm Hg (95% CI, 0.56–3.37) higher diastolic blood pressure. In conclusion, widespread environmental lead exposure is evident in urban Haiti, with higher lead levels associated with higher systolic and diastolic blood pressure. Lead is a current and potentially modifiable pollutant in lower-income countries that warrants urgent public health remediation. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03892265.

Substance use in adolescents with environmental lead exposure in childhood

2014 ◽  
Vol 140 ◽  
pp. e170-e171 ◽  
Author(s):  
Antonio Pascale ◽  
Cristina B. Bares ◽  
A. Sosa ◽  
M.J. Moll ◽  
S. Couto ◽  
...  
Keyword(s):  
Substance Use ◽  
Lead Exposure ◽  
Environmental Lead ◽  
Environmental Lead Exposure

Environmental Lead Exposure Among Children in Chengdu, China, 2007–2009

2010 ◽  
Vol 143 (1) ◽  
pp. 97-102 ◽  
Author(s):  
Hua Shi ◽  
Yong-mei Jiang ◽  
Jia-yuan Li ◽  
Fang Liu ◽  
Hong Wang ◽  
...  
Keyword(s):  
Lead Exposure ◽  
Environmental Lead ◽  
Environmental Lead Exposure

scholarly journals Association between Inflammatory Marker, Environmental Lead Exposure, and Glutathione S-Transferase Gene

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Jintana Sirivarasai ◽  
Winai Wananukul ◽  
Sming Kaojarern ◽  
Suwannee Chanprasertyothin ◽  
Nisakron Thongmung ◽  
...  
Keyword(s):  
Lead Exposure ◽  
Inflammatory Marker ◽  
Blood Lead ◽  
Genetic Determinants ◽  
Glutathione S Transferase ◽  
Environmental Lead ◽  
Gst Polymorphisms ◽  
Gst Polymorphism ◽  
Hs Crp ◽  
Environmental Lead Exposure

A number of studies suggested that lead is related to the induction of oxidative stress, and alteration of immune response. In addition, modifying these toxic effects varied partly by GST polymorphism. The objectives of this study were to assess the association between the lead-induced alteration in serum hs-CRP, with GSTM1, GSTT1, and GSTP1 Val105Ile genetic variations and the health consequence from environmental lead exposure. The 924 blood samples were analyzed for blood lead, CRP, and genotyping of three genes with real-time PCR. Means of blood lead and serum hs-CRP were 5.45 μg/dL and 2.07 mg/L. Both CRP and systolic blood pressure levels were significantly higher for individuals with blood lead in quartile 4 (6.48–24.63 μg/dL) compared with those in quartile 1 (1.23–3.47 μg/dL,P<0.01). In particular, in men with blood lead >6.47 μg/dL the adjusted odds ratio (OR) of CRP levels for individuals with GSTP1 variants allele, GSTM1 null, GSTT1 null, double-null GSTM1, and GSTT1 compared with wild-type allele was 1.46 (95% CI; 1.05–2.20), 1.32 (95% CI; 1.03–1.69), 1.65 (95% CI; 1.17–2.35), and 1.98 (95% CI; 1.47–2.55), respectively. Our findings suggested that lead exposure is associated with adverse changes in inflammatory marker and SBP. GST polymorphisms are among the genetic determinants related to lead-induced inflammatory response.

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