Regional mapping of human DNA excision repair gene ERCC4 to chromosome 16pl3.13–pl3.2

Mutagenesis ◽  
1993 ◽  
Vol 8 (3) ◽  
pp. 199-205 ◽  
Author(s):  
P. Liu ◽  
J. Siciliano ◽  
B. White ◽  
R. Legerski ◽  
D. Callen ◽  
...  
Keyword(s):  
Excision Repair ◽  
Regional Mapping ◽  
Repair Gene ◽  
Dna Excision Repair ◽  
Human Dna

scholarly journals The cloned human DNA excision repair gene ERCC-1 fails to correct xeroderma pigmentosum complementation groups A through I

1989 ◽  
Vol 217 (2) ◽  
pp. 83-92 ◽  
Author(s):  
M. van Duin ◽  
G. Vredeveldt ◽  
L.V. Mayne ◽  
H. Odijk ◽  
W. Vermeulen ◽  
...  
Keyword(s):  
Xeroderma Pigmentosum ◽  
Excision Repair ◽  
Repair Gene ◽  
Dna Excision Repair ◽  
Human Dna ◽  
Complementation Groups

Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain

Nature ◽  
1990 ◽  
Vol 348 (6296) ◽  
pp. 73-76 ◽  
Author(s):  
Kiyoji Tanaka ◽  
Naoyuki Miura ◽  
Ichiro Satokata ◽  
Iwai Miyamoto ◽  
Michihiro C. Yoshida ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Xeroderma Pigmentosum ◽  
Excision Repair ◽  
Zinc Finger Domain ◽  
Repair Gene ◽  
Dna Excision Repair ◽  
Human Dna ◽  
Group A

scholarly journals Molecular cloning and chromosomal localization of DNA sequences associated with a human DNA repair gene.

1985 ◽  
Vol 5 (2) ◽  
pp. 398-405 ◽  
Author(s):  
J S Rubin ◽  
V R Prideaux ◽  
H F Willard ◽  
A M Dulhanty ◽  
G F Whitmore ◽  
...  
Keyword(s):  
Dna Repair ◽  
Dna Sequences ◽  
Chromosomal Localization ◽  
Excision Repair ◽  
Repair Process ◽  
Human Cells ◽  
Gene Products ◽  
Repair Gene ◽  
Human Dna ◽  
Dna Repair Gene

The genes and gene products involved in the mammalian DNA repair processes have yet to be identified. Toward this end we made use of a number of DNA repair-proficient transformants that were generated after transfection of DNA from repair-proficient human cells into a mutant hamster line that is defective in the initial incision step of the excision repair process. In this report, biochemical evidence is presented that demonstrates that these transformants are repair proficient. In addition, we describe the molecular identification and cloning of unique DNA sequences closely associated with the transfected human DNA repair gene and demonstrate the presence of homologous DNA sequences in human cells and in the repair-proficient DNA transformants. The chromosomal location of these sequences was determined by using a panel of rodent-human somatic cell hybrids. Both unique DNA sequences were found to be on human chromosome 19.

scholarly journals Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Definedin VitroSystem

2014 ◽  
Vol 289 (8) ◽  
pp. 5074-5082 ◽  
Author(s):  
Laura A. Lindsey-Boltz ◽  
Michael G. Kemp ◽  
Joyce T. Reardon ◽  
Vanessa DeRocco ◽  
Ravi R. Iyer ◽  
...  
Keyword(s):  
Dna Damage ◽  
Excision Repair ◽  
Dna Damage Checkpoint ◽  
Dna Excision Repair ◽  
Human Dna

Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA

Nature ◽  
1995 ◽  
Vol 377 (6545) ◽  
pp. 169-173 ◽  
Author(s):  
Annemieke de Vries ◽  
Conny Th. M. van Oostrom ◽  
Frans M. A. Hofhuis ◽  
Paul M. Dortant ◽  
Rob J. W. Berg ◽  
...  
Keyword(s):  
Excision Repair ◽  
Ultraviolet B ◽  
Repair Gene ◽  
Dna Excision Repair ◽  
Increased Susceptibility

scholarly journals Molecular cloning of the human DNA excision repair gene ERCC-6.

1990 ◽  
Vol 10 (11) ◽  
pp. 5806-5813 ◽  
Author(s):  
C Troelstra ◽  
H Odijk ◽  
J de Wit ◽  
A Westerveld ◽  
L H Thompson ◽  
...  
Keyword(s):  
Excision Repair ◽  
Mutant Cell ◽  
Chinese Hamster ◽  
Complementation Group ◽  
Cyclobutane Pyrimidine Dimers ◽  
Repair Gene ◽  
Human Dna ◽  
Pyrimidine Dimers ◽  
Low Efficiency ◽  
Mutant Lines

The UV-sensitive, nucleotide excision repair-deficient Chinese hamster mutant cell line UV61 was used to identify and clone a correcting human gene, ERCC-6. UV61, belonging to rodent complementation group 6, is only moderately UV sensitive in comparison with mutant lines in groups 1 to 5. It harbors a deficiency in the repair of UV-induced cyclobutane pyrimidine dimers but permits apparently normal repair of (6-4) photoproducts. Genomic (HeLa) DNA transfections of UV61 resulted, with a very low efficiency, in six primary and four secondary UV-resistant transformants having regained wild-type UV survival. Southern blot analysis revealed that five primary and only one secondary transformant retained human sequences. The latter line was used to clone the entire 115-kb human insert. Coinheritance analysis demonstrated that five of the other transformants harbored a 100-kb segment of the cloned human insert. Since it is extremely unlikely that six transformants all retain the same stretch of human DNA by coincidence, we conclude that the ERCC-6 gene resides within this region and probably covers most of it. The large size of the gene explains the extremely low transfection frequency and makes the gene one of the largest cloned by genomic DNA transfection. Four transformants did not retain the correcting ERCC-6 gene and presumably have reverted to the UV-resistant phenotype. One of these appeared to have amplified an endogenous, mutated CHO ERCC-6 allele, indicating that the UV61 mutation is leaky and can be overcome by gene amplification.

scholarly journals Coupling of Human DNA Excision Repair and the ATR‐mediated DNA Damage Checkpoint

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Laura Lindsey‐Boltz ◽  
Michael Kemp ◽  
Joyce Reardon ◽  
Vanessa DeRocco ◽  
Ravi Iyer ◽  
...  
Keyword(s):  
Dna Damage ◽  
Excision Repair ◽  
Dna Damage Checkpoint ◽  
Dna Excision Repair ◽  
Human Dna
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