The predictivity of animal bioassays and short-term genotoxicity tests for carcinogenicity and non-carcinogenicity to humans

Mutagenesis ◽  
1987 ◽  
Vol 2 (2) ◽  
pp. 73-78 ◽  
Author(s):  
Fanny K. Ennever ◽  
Thomas J. Noonan ◽  
Herbert S. Rosenkranz
Keyword(s):  
Short Term ◽  
Genotoxicity Tests

Prediction of carcinogenic potency by short-term genotoxicity tests

Mutagenesis ◽  
1987 ◽  
Vol 2 (1) ◽  
pp. 39-44 ◽  
Author(s):  
Fanny K. Ennever ◽  
Herbert S. Rosenkranz
Keyword(s):  
Short Term ◽  
Carcinogenic Potency ◽  
Genotoxicity Tests

Strategies for optimization of short-term genotoxicity tests: the synergistic effect of NADPH and NADH on P450 function in processing pre mutagens

Mutagenesis ◽  
1990 ◽  
Vol 5 (1) ◽  
pp. 51-54 ◽  
Author(s):  
M. Paolini ◽  
E. Sapigni ◽  
P. Hrelia ◽  
S. Grilli ◽  
G. Lattanzi ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Short Term ◽  
Genotoxicity Tests

Evaluating batteries of short-term genotoxicity tests

Mutagenesis ◽  
1986 ◽  
Vol 1 (4) ◽  
pp. 293-298 ◽  
Author(s):  
Fanny K. Ennever ◽  
S. Rosenkranz
Keyword(s):  
Short Term ◽  
Genotoxicity Tests

Detection of Genotoxins in the Aquatic Environment with the Mussel Mytilus Edulis

1992 ◽  
Vol 25 (11) ◽  
pp. 317-324 ◽  
Author(s):  
M. N. Wrisberg ◽  
R. Rhemrev
Keyword(s):  
Mytilus Edulis ◽  
Dna Adducts ◽  
Blood Cells ◽  
Laboratory Experiments ◽  
Blue Mussel ◽  
Contaminated Sediment ◽  
Short Term ◽  
Mussel Tissue ◽  
Biomonitoring Tool ◽  
Genotoxicity Tests

The blue mussel, Mytilus edulis is often used in marine biomonitoring programs. In this paper two different genotoxicity tests are considered as possible indicators for genotoxic pollution in the marine environment. One is focusing on micronucleus (MN) analysis in the blood cells of mussels and the other on the detection of DNA-adducts in the whole mussel tissue. The induction of MN has been studied in short-term laboratory experiments, during which mussels were exposed to standard genotoxins or waste water. Both genotoxicity tests have been applied in a study where mussels were exposed to contaminated sediment under controlled mesocosm conditions. These studies indicate that the MN mussel test may be used as a sensitive indicator of genotoxic pollution, although the inducibility of MN in the blood cells appears to be limited and to some extent seasonally dependent. The detection of DNA-adducts is still under development, but the preliminary result seems promising for its application as a biomonitoring tool.

Conceptual short-term memory (CSTM) supports core claims of Christiansen and Chater

2016 ◽  
Vol 39 ◽  
Author(s):  
Mary C. Potter
Keyword(s):  
Working Memory ◽  
Rapid Serial Visual Presentation ◽  
Language Comprehension ◽  
Short Term Memory ◽  
Visual Presentation ◽  
Long Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Use Of Knowledge

AbstractRapid serial visual presentation (RSVP) of words or pictured scenes provides evidence for a large-capacity conceptual short-term memory (CSTM) that momentarily provides rich associated material from long-term memory, permitting rapid chunking (Potter 1993; 2009; 2012). In perception of scenes as well as language comprehension, we make use of knowledge that briefly exceeds the supposed limits of working memory.

Ultrastructural Changes of Canine Kidneys During 24-Hour Perfusion on a LI-400 Preservation System

1971 ◽  
Vol 29 ◽  
pp. 316-317
Author(s):  
M. O. Magnusson ◽  
D. G. Osborne ◽  
T. Shimoji ◽  
W. S. Kiser ◽  
W. A. Hawk
Keyword(s):  
Electron Microscopy ◽  
Electrolyte Solution ◽  
Ultrastructural Changes ◽  
Midline Incision ◽  
Short Term ◽  
Pentobarbital Anesthesia ◽  
Pulsatile Perfusion

Short term experimental and clinical preservation of kidneys is presently best accomplished by hypothermic continuous pulsatile perfusion with cryoprecipitated and millipore filtered plasma. This study was undertaken to observe ultrastructural changes occurring during 24-hour preservation using the above mentioned method.A kidney was removed through a midline incision from healthy mongrel dogs under pentobarbital anesthesia. The kidneys were flushed immediately after removal with chilled electrolyte solution and placed on a LI-400 preservation system and perfused at 8-10°C. Serial kidney biopsies were obtained at 0-½-1-2-4-8-16 and 24 hours of preservation. All biopsies were prepared for electron microscopy. At the end of the preservation period the kidneys were autografted.

Polychlorinated biphenyl induced hepatocyte alterations

1987 ◽  
Vol 45 ◽  
pp. 716-717
Author(s):  
D.N. Collins ◽  
J.N. Turner ◽  
K.O. Brosch ◽  
R.F. Seegal
Keyword(s):  
Lipid Droplets ◽  
Wistar Rats ◽  
Homovanillic Acid ◽  
Polychlorinated Biphenyl ◽  
Corn Oil ◽  
Environmental Pollutants ◽  
Short Term ◽  
Pcb Congeners ◽  
Urinary Levels ◽  
The Brain

Polychlorinated biphenyls (PCBs) are a ubiquitous class of environmental pollutants with toxic and hepatocellular effects, including accumulation of fat, proliferated smooth endoplasmic recticulum (SER), and concentric membrane arrays (CMAs) (1-3). The CMAs appear to be a membrane storage and degeneration organelle composed of a large number of concentric membrane layers usually surrounding one or more lipid droplets often with internalized membrane fragments (3). The present study documents liver alteration after a short term single dose exposure to PCBs with high chlorine content, and correlates them with reported animal weights and central nervous system (CNS) measures. In the brain PCB congeners were concentrated in particular regions (4) while catecholamine concentrations were decreased (4-6). Urinary levels of homovanillic acid a dopamine metabolite were evaluated (7).Wistar rats were gavaged with corn oil (6 controls), or with a 1:1 mixture of Aroclor 1254 and 1260 in corn oil at 500 or 1000 mg total PCB/kg (6 at each level).

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