scholarly journals Possible age-dependent adaptive response to a low dose of X-rays in human lymphocytes

Mutagenesis ◽  
1998 ◽  
Vol 13 (2) ◽  
pp. 151-152 ◽  
Author(s):  
RK-Gadhia
Keyword(s):  
Adaptive Response ◽  
Low Dose ◽  
Human Lymphocytes ◽  
X Rays ◽  
Age Dependent

Studies of the 'Adaptive' Repair Response in Human Lymphocytes and V79 Cells after Treatment with MNNG and MNU

1988 ◽  
Vol 7 (4) ◽  
pp. 337-341 ◽  
Author(s):  
D. Anderson ◽  
P. Fisher ◽  
P.C. Jenkinson ◽  
B.J. Phillips
Keyword(s):  
Adaptive Response ◽  
Mammalian Cells ◽  
Tritiated Thymidine ◽  
Human Lymphocytes ◽  
Alternative Methods ◽  
X Rays ◽  
V79 Cells ◽  
Repair Mechanisms ◽  
Experimental Protocols ◽  
Mutagenic Effects

In bacteria, there is evidence that a damage inducible repair response system known as the adaptive response exists since pretreatment with low doses of a simple monofunctional alkylating agent leads to a decrease in both the lethal and mutagenic effects of a subsequent challenge dose of the agent. The evidence for an analagous system in mammalian cells has proved to be inconsistent to date. The induction of chromosome repair mechanisms in human cells by low-dose radiation from tritiated thymidine has been shown to make the cells refractory to the induction of chromosome aberrations by X-rays. The present communication investigates the induction of an adaptive response in human lymphocytes from four donors and V79 cells using SCE and mutation as endpoints and MNNG and MNU for the adapting and challenging treatment. It is clear that a reproducible model of the adaptive response in human lymphocytes is difficult to establish because of the variability between different donors and different culture times. In V79 cells, assays with much larger cell numbers are required to detect a reproducible response with such small changes in mutant frequency. To demonstrate an adaptive response conclusively in mammalian cells will probably require the use of more sensitive experimental protocols and alternative methods of administration of adaptive doses of mutagen.

Effects of Medical Diagnostic Low-dose X Rays on Human Lymphocytes

2017 ◽  
Vol 112 (5) ◽  
pp. 458-464 ◽  
Author(s):  
Montree Tungjai ◽  
Nutnicha Phathakanon ◽  
Kanokporn Noy Rithidech
Keyword(s):  
Low Dose ◽  
Human Lymphocytes ◽  
X Rays ◽  
Medical Diagnostic

Adaptive response in human lymphocytes conditioned with hydrogen peroxide before irradiation with X-rays

Mutagenesis ◽  
1990 ◽  
Vol 5 (6) ◽  
pp. 555-557 ◽  
Author(s):  
F. Cortés ◽  
I. Dominguez ◽  
J. Pi`ero ◽  
J. C. Mateos
Keyword(s):  
Hydrogen Peroxide ◽  
Adaptive Response ◽  
Human Lymphocytes ◽  
X Rays
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