scholarly journals The centromere as a target for the induction of chromosome damage in resting and proliferating mammalian cells: assessment of mitomycin C-induced genetic damage at kinetochores and centromeres by a micronucleus test in mouse splenocytes

Mutagenesis ◽  
1996 ◽  
Vol 11 (2) ◽  
pp. 133-138 ◽  
Author(s):  
Luigina Renzi ◽  
Francesca Pacchierotti ◽  
Antonella Russo
Keyword(s):  
Mitomycin C ◽  
Mammalian Cells ◽  
Micronucleus Test ◽  
Chromosome Damage ◽  
Genetic Damage ◽  
Mouse Splenocytes

Genetic damage to a fern population growing in a polluted environment: segregation and description of gametophyte mutants

1977 ◽  
Vol 55 (5) ◽  
pp. 542-548 ◽  
Author(s):  
Edward J. Klekowski Jr. ◽  
Edward L. Davis
Keyword(s):  
Maternal Effect ◽  
High Frequency ◽  
Female Parent ◽  
Chromosome Damage ◽  
Polluted Environment ◽  
Genetic Damage ◽  
Polluted River ◽  
Polluted Sites

A population of the fern Osmunda regalis growing in a polluted river was investigated genetically. Previous studies documented a high frequency of postzygotically induced genetic and chromosome damage. This paper describes two categories of gametophytic mutants which occurred in the progeny of this population. A gametophyte phenotype which exhibited a maternal effect on the sporophyte generation when it was the female parent occurred in 7.8% of the spore sample. A gametophyte phenotype which could best be characterized as a neuter calluslike mass occurred in 6.6% of the spore sample. Studies of nearby O. regalis populations in non-polluted sites failed to document the presence of such phenotypes in the spore samples.

Storage enhances chromosome damage after exposure of human leukocytes to mitomycin C

Nature ◽  
1980 ◽  
Vol 284 (5754) ◽  
pp. 370-372 ◽  
Author(s):  
H. J. Evans ◽  
Vijayalaxmi
Keyword(s):  
Mitomycin C ◽  
Chromosome Damage ◽  
Human Leukocytes
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