scholarly journals Meta-Analysis of Retrograde Signaling in Arabidopsis thaliana Reveals a Core Module of Genes Embedded in Complex Cellular Signaling Networks

2014 ◽  
Vol 7 (7) ◽  
pp. 1167-1190 ◽  
Author(s):  
Christine Gläßer ◽  
Georg Haberer ◽  
Iris Finkemeier ◽  
Thomas Pfannschmidt ◽  
Tatjana Kleine ◽  
...  
Keyword(s):  
Arabidopsis Thaliana ◽  
Cellular Signaling ◽  
Meta Analysis ◽  
Retrograde Signaling ◽  
Signaling Networks ◽  
Core Module

scholarly journals A Core Module of Nuclear Genes Regulated by Biogenic Retrograde Signals from Plastids

Plants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 296
Author(s):  
Björn Grübler ◽  
Carolina Cozzi ◽  
Thomas Pfannschmidt
Keyword(s):  
Signaling Pathway ◽  
Expression Profiles ◽  
Meta Analysis ◽  
Gene Expression Profiles ◽  
Nuclear Gene ◽  
Nuclear Genes ◽  
Retrograde Signaling ◽  
Chloroplast Biogenesis ◽  
Core Module ◽  
The Impact

Chloroplast biogenesis during seedling development of angiosperms is a rapid and highly dynamic process that parallels the light-dependent photomorphogenic programme. Pre-treatments of dark-grown seedlings with lincomyin or norflurazon prevent chloroplast biogenesis upon illumination yielding albino seedlings. A comparable phenotype was found for the Arabidopsis mutant plastid-encoded polymerase associated protein 7 (pap7) being defective in the prokaryotic-type plastid RNA polymerase. In all three cases the defect in plastid function has a severe impact on the expression of nuclear genes representing the influence of retrograde signaling pathway(s) from the plastid. We performed a meta-analysis of recently published genome-wide expression studies that investigated the impact of the aforementioned chemical and genetic blocking of chloroplast biogenesis on nuclear gene expression profiles. We identified a core module of 152 genes being affected in all three conditions. These genes were classified according to their function and analyzed with respect to their implication in retrograde signaling and chloroplast biogenesis. Our study uncovers novel genes regulated by retrograde biogenic signals and suggests the action of a common signaling pathway that is used by signals originating from plastid transcription, translation and oxidative stress.

ATR inhibition rewires cellular signaling networks induced by replication stress

PROTEOMICS ◽  
2016 ◽  
Vol 16 (3) ◽  
pp. 402-416 ◽  
Author(s):  
Sebastian A. Wagner ◽  
Hannah Oehler ◽  
Andrea Voigt ◽  
Denis Dalic ◽  
Anja Freiwald ◽  
...  
Keyword(s):  
Cellular Signaling ◽  
Replication Stress ◽  
Signaling Networks

Deconvoluting apocarotenoid‐mediated retrograde signaling networks regulating plastid translation and leaf development

2020 ◽  
Author(s):  
Lina Escobar‐Tovar ◽  
Julio Sierra ◽  
Arihel Hernández‐Muñoz ◽  
Ryan P. McQuinn ◽  
Sandra Mathioni ◽  
...  
Keyword(s):  
Leaf Development ◽  
Retrograde Signaling ◽  
Signaling Networks

Quantitative multiplexed profiling of cellular signaling networks using phosphotyrosine-specific DNA-tagged SH2 domains

2006 ◽  
Vol 3 (9) ◽  
pp. 737-744 ◽  
Author(s):  
Kevin Dierck ◽  
Kazuya Machida ◽  
Anja Voigt ◽  
Julian Thimm ◽  
Martin Horstmann ◽  
...  
Keyword(s):  
Cellular Signaling ◽  
Signaling Networks ◽  
Sh2 Domains

scholarly journals Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma

2007 ◽  
Vol 104 (31) ◽  
pp. 12867-12872 ◽  
Author(s):  
P. H. Huang ◽  
A. Mukasa ◽  
R. Bonavia ◽  
R. A. Flynn ◽  
Z. E. Brewer ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Therapeutic Strategy ◽  
Cellular Signaling ◽  
Signaling Networks

scholarly journals A Meta-Analysis Reveals the Commonalities and Differences in Arabidopsis thaliana Response to Different Viral Pathogens

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e40526 ◽  
Author(s):  
Guillermo Rodrigo ◽  
Javier Carrera ◽  
Virgina Ruiz-Ferrer ◽  
Francisco J. del Toro ◽  
César Llave ◽  
...  
Keyword(s):  
Arabidopsis Thaliana ◽  
Meta Analysis ◽  
Viral Pathogens
Sign in / Sign up

Export Citation Format

Share Document