scholarly journals Subcellular Localization and In Vivo Interactions of the Arabidopsis thaliana Ethylene Receptor Family Members

2008 ◽  
Vol 1 (2) ◽  
pp. 308-320 ◽  
Author(s):  
Christopher Grefen ◽  
Katrin Städele ◽  
Kamil Růžička ◽  
Petr Obrdlik ◽  
Klaus Harter ◽  
...  
2005 ◽  
Vol 41 (5) ◽  
pp. 651-659 ◽  
Author(s):  
Ronan C. O'Malley ◽  
Fernando I. Rodriguez ◽  
Jeffrey J. Esch ◽  
Brad M. Binder ◽  
Philip O'Donnell ◽  
...  

2005 ◽  
Vol 16 (4) ◽  
pp. 1735-1743 ◽  
Author(s):  
Anna-Lisa Paul ◽  
Paul C. Sehnke ◽  
Robert J. Ferl

In most higher eukaryotes, the predominantly phosphoprotein-binding 14-3-3 proteins are the products of a multigene family, with many organisms having 10 or more family members. However, current models for 14-3-3/phosphopeptide interactions suggest that there is little specificity among 14-3-3s for diverse phosphopeptide clients. Therefore, the existence of sequence diversity among 14-3-3s within a single organism begs questions regarding the in vivo specificities of the interactions between the various 14-3-3s and their clients. Chief among those questions is, Do the different 14-3-3 isoforms interact with different clients within the same cell? Although the members of the Arabidopsis 14-3-3 family of proteins typically contain highly conserved regions of sequence, they also display distinctive variability with deep evolutionary roots. In the current study, a survey of several Arabidopsis 14-3-3/GFP fusions revealed that 14-3-3s demonstrate distinct and differential patterns of subcellular distribution, by using trichomes and stomate guard cells as in vivo experimental cellular contexts. The effects of client interaction on 14-3-3 localization were further analyzed by disrupting the partnering with peptide and chemical agents. Results indicate that 14-3-3 localization is both isoform specific and highly dependent upon interaction with cellular clients.


2012 ◽  
Vol 63 (17) ◽  
pp. 6125-6138 ◽  
Author(s):  
Irene Stenzel ◽  
Markus Otto ◽  
Carolin Delker ◽  
Nils Kirmse ◽  
Diana Schmidt ◽  
...  

Cytokine ◽  
1998 ◽  
Vol 10 (10) ◽  
pp. 773-780 ◽  
Author(s):  
Simona Saccani ◽  
Nadia Polentarutti ◽  
Giselle Penton-Rol ◽  
John E. Sims ◽  
Alberto Mantovani

Blood ◽  
2017 ◽  
Vol 130 (8) ◽  
pp. 1014-1025 ◽  
Author(s):  
Lynne R. Prince ◽  
Svenja D. Prosseda ◽  
Kathryn Higgins ◽  
Jennifer Carlring ◽  
Elizabeth C. Prestwich ◽  
...  

Key Points We demonstrate an important role for NR4A receptors in regulating neutrophil lifespan and homeostasis in vitro and in vivo. These findings may define targets for therapies for diseases driven by defects in neutrophil number and/or survival.


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