scholarly journals Plasminogen activator inhibitor-1 4G/5G and 5,10-methylene-tetrahydrofolate reductase C677T polymorphisms in polycystic ovary syndrome

2008 ◽  
Vol 15 (1) ◽  
pp. 19-26 ◽  
Author(s):  
P. G. Bagos
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Plasminogen Activator ◽  
Polycystic Ovary ◽  
Plasminogen Activator Inhibitor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Ovary Syndrome ◽  
Methylene Tetrahydrofolate Reductase ◽  
Methylene Tetrahydrofolate ◽  
Activator Inhibitor

scholarly journals Plasma plasminogen activator inhibitor-1 levels in the different phenotypes of the polycystic ovary syndrome

2012 ◽  
Vol 59 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Ekaterini Koiou ◽  
Konstantinos Tziomalos ◽  
Konstantinos Dinas ◽  
Ilias Katsikis ◽  
Eleni A. Kandaraki ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Plasminogen Activator ◽  
Polycystic Ovary ◽  
Plasminogen Activator Inhibitor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Ovary Syndrome ◽  
Activator Inhibitor

scholarly journals Prevalence of Metabolic Syndrome and Related Characteristics in Obese Adolescents with and without Polycystic Ovary Syndrome

2008 ◽  
Vol 93 (12) ◽  
pp. 4780-4786 ◽  
Author(s):  
Brooke Rossi ◽  
Sara Sukalich ◽  
Jennifer Droz ◽  
Adam Griffin ◽  
Stephen Cook ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Polycystic Ovary Syndrome ◽  
Plasminogen Activator ◽  
Polycystic Ovary ◽  
Plasminogen Activator Inhibitor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Ovary Syndrome ◽  
Obese Adolescents ◽  
Activator Inhibitor

Context: Adults with polycystic ovary syndrome (PCOS) may be at increased risk for metabolic syndrome (MBS) and related cardiovascular disease. It is not clear whether PCOS diagnosed in adolescence increases the risk of MBS in this age group. Objective: The aim was to compare the prevalence and related characteristics of MBS in obese adolescents with and without PCOS. Design: We conducted a cross-sectional study of overweight and obese PCOS adolescents and BMI matched controls. Patients and Participants: A total of 74 subjects, 43 with PCOS and 31 controls, participated in the study. Interventions: Each subject underwent a physical examination and laboratory evaluation for a diagnosis of MBS. Regional fat distribution was determined by computerized tomography scan in the PCOS adolescents. Main Outcome Measures: We measured the prevalence of MBS and its components in adolescent subjects and controls. Results: The PCOS group had larger ovarian volume and higher measures of total testosterone and free androgen index than controls, but there were no differences in waist circumference, fasting glucose, blood pressure, or lipids. PCOS adolescents demonstrated more glucose abnormalities and higher plasminogen activator inhibitor-1. By pediatric criteria, 53% of the PCOS and 55% of the control adolescents had MBS. By adult criteria, 26% of PCOS and 29% of controls met diagnostic criteria for MBS. Conclusions: Obese adolescent women have a high prevalence of MBS, and PCOS does not add additional risk for MBS. There appears to be an association between MBS and visceral adiposity. PCOS is associated with increased incidence of glucose intolerance and increased plasminogen activator inhibitor-1. Our results reinforce the importance of obesity counseling in adolescents to recognize the possible risk of future cardiovascular disease in these young women.

scholarly journals Investigation of plasminogen activator inhibitor-1 (PAI-1) levels in patients diagnosed with polycystic ovary syndrome

2021 ◽  
Vol 3 (1) ◽  
pp. 6-9
Author(s):  
İhsan Bağlı ◽  
Mert Küçük
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Plasminogen Activator ◽  
Polycystic Ovary ◽  
Plasminogen Activator Inhibitor ◽  
Model Assessment ◽  
Plasminogen Activator Inhibitor 1 ◽  
Ovary Syndrome ◽  
Pcos Group ◽  
Activator Inhibitor ◽  
Pai 1

Objective:The aim of this study was to investigate the plasma levels of plasminogen activator inhibitor -1 (PAI-1) known as a potent inhibitor of fibrinolysis in women with polycystic ovary syndrome (PCOS) and compare with health controls. Methods: Forty women with PCOS diagnosed using 2003 revised Rotterdam criteria and 40 healthy women who attended to Adnan Menderes University Department of Obstetrics and Gynecology between July-October 2013 were recruited to this prospective study. We noted all participant’s demographic features, calculated body mass index (BMI), waist hip ratio (WHR), and measured blood pressures. We performed modified Ferriman-Gallwey Score (mFGS) and calculated Luteinizing hormone (LH)/Follicle stimulating hormone (FSH) ratio and homeostatic model assessment insulin resistance (HOMA-IR) of participants. PAI-1 levels were measured by using the Human PAI-1 Elisa test. We used the student T test and Mann-Whitney U test as statistical methods. A p-value less than 0.05 was considered statistically significant. Results: We found PAI-1 levels, fasting insulin levels, HOMA-IR index, BMI significantly higher in the PCOS group compared with the control group. Mean age of the participants was found lower in the PCOS group. Between the groups we found no statistically significant differences in terms of the LH/FSH ratio, fasting glucose, dehydroepiandrosterone and testosterone levels.

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