scholarly journals Mannose-binding lectin (MBL) codon 54 gene polymorphism protects against development of pre-eclampsia, HELLP syndrome and pre-eclampsia-associated intrauterine growth restriction

2007 ◽  
Vol 13 (4) ◽  
pp. 281-285 ◽  
Author(s):  
I. Sziller ◽  
O. Babula ◽  
P. Hupuczi ◽  
B. Nagy ◽  
B. Rigó ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Intrauterine Growth Restriction ◽  
Hellp Syndrome ◽  
Mannose Binding Lectin ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Mannose Binding ◽  
Binding Lectin

Association of maternal and/or fetal factor V Leiden and G20210A prothrombin mutation with HELLP syndrome and intrauterine growth restriction

2003 ◽  
Vol 105 (3) ◽  
pp. 279-285 ◽  
Author(s):  
Dietmar SCHLEMBACH ◽  
Ernst BEINDER ◽  
Juergen ZINGSEM ◽  
Ute WUNSIEDLER ◽  
Matthias W. BECKMANN ◽  
...  
Keyword(s):  
Blood Flow ◽  
Intrauterine Growth Restriction ◽  
Hellp Syndrome ◽  
Factor V Leiden ◽  
Growth Restriction ◽  
Control Group ◽  
Factor V ◽  
Intrauterine Growth ◽  
Prothrombin Mutation ◽  
Thrombophilic Mutations

This study was conducted to investigate the association of maternal and/or fetal factor V Leiden (FVL) and G20210A prothrombin mutation with HELLP syndrome. FVL and G20210A prothrombin mutation were determined using PCR. Sixty-three pregnant women, 36 of them diagnosed with HELLP syndrome, were included in the study. Overall, 68 children were born as a result of these pregnancies and blood sampling was possible in 28 out of 39 children from HELLP patients and 25 out of 29 children from the control women. The prevalence of a maternal FVL was elevated 2-fold in HELLP patients compared with the control women [six out of 36 (16.7%) compared with two out of 27 (7.4%); P=0.282]. None of the HELLP patients and only one woman in the control group was found to be positive for the G20210A prothrombin mutation (P=0.251). The fetal carrier frequency was four out of 28 compared with three out of 25 for FVL (P=0.811), and two out of 28 compared with one out of 25 for G20210A prothrombin mutation (P=0.629). Intrauterine growth restriction (IUGR) was significantly higher in fetuses found to be positive for a thrombophilic mutation (P=0.022). IUGR occurred in seven out of ten fetuses with a thrombophilic mutation compared with 11 out of 43 in fetuses without a mutation. The prevalence of FVL, but not of the G20210A prothrombin mutation, seems to be elevated in women with HELLP syndrome. A fetal thrombophilic mutation does not contribute significantly to the clinical features of the HELLP syndrome. Our results demonstrate a fetal contribution to IUGR. Fetal thrombophilic mutations may lead to placental microthrombosis, which consecutively could lead to a disturbed fetoplacental blood flow and thus cause growth restriction.

scholarly journals Mannose-binding lectin 2 (MBL2) gene polymorphism in asthma and atopy among adults

2005 ◽  
Vol 142 (1) ◽  
pp. 120-124 ◽  
Author(s):  
J. Aittoniemi ◽  
H. Soranummi ◽  
A. T. Rovio ◽  
M. Hurme ◽  
T. Pessi ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Mannose Binding Lectin ◽  
Mbl2 Gene ◽  
Mannose Binding ◽  
Binding Lectin

The role of methylentetrahydrofolate reductase (MTHFR) gene polymorphism in intrauterine growth restriction development

2018 ◽  
Vol 12_2018 ◽  
pp. 23-28
Author(s):  
Tyutyunnik V.L. Tyutyunnik ◽  
Kan N.E. Kan ◽  
Mantrova D.A. Mantrova ◽  
Lomova N.A. Lomova N ◽  
Klimantsev I.V. Klimantsev ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Intrauterine Growth Restriction ◽  
Mthfr Gene ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Mthfr Gene Polymorphism ◽  
Methylentetrahydrofolate Reductase

Alpha hemoglobin stabilizing protein (AHSP) in hemolysis elevated liver enzyme and low platelet (HELLP) syndrome, intrauterine growth restriction (IUGR) and fetal death

2005 ◽  
Vol preprint (2007) ◽  
pp. 1
Author(s):  
Monica Emanuelli ◽  
Davide Sartini ◽  
Valentina Rossi ◽  
Alessandra Corradetti ◽  
Beatrice Landi ◽  
...  
Keyword(s):  
Liver Enzyme ◽  
Intrauterine Growth Restriction ◽  
Hellp Syndrome ◽  
Fetal Death ◽  
Elevated Liver Enzyme ◽  
Growth Restriction ◽  
Intrauterine Growth

281: A mannose-binding lectin (MBL) gene polymorphism is associated with increased insulin resistance in pregnant hispanic women

2013 ◽  
Vol 208 (1) ◽  
pp. S127
Author(s):  
Mariana Passos ◽  
Theofano Orfanelli ◽  
Georgios Doulaveris ◽  
Aswathi Jayaram ◽  
Shirlee Jaffe ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Gene Polymorphism ◽  
Hispanic Women ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Binding Lectin

Smoking status interacts with the association between mannose-binding lectin serum levels and gene polymorphism and the carriage of oropharyngeal bacteria

2010 ◽  
Vol 71 (3) ◽  
pp. 298-303 ◽  
Author(s):  
Ulla Jounio ◽  
Aino Rantala ◽  
Aini Bloigu ◽  
Raija Juvonen ◽  
Taina Lajunen ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Smoking Status ◽  
Serum Levels ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Binding Lectin
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