scholarly journals Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue

2006 ◽  
Vol 12 (5) ◽  
pp. 301-308 ◽  
Author(s):  
M. J. Jasper
Keyword(s):  
Transcription Factor ◽  
Unexplained Infertility ◽  
Endometrial Tissue ◽  
T Regulatory Cell ◽  
Regulatory Cell

Resveratrol Ameliorates Dysregulation of Th1, Th2, Th17, and T Regulatory Cell-Related Transcription Factor Signaling in a BTBR T + tf/J Mouse Model of Autism

2016 ◽  
Vol 54 (7) ◽  
pp. 5201-5212 ◽  
Author(s):  
Saleh A. Bakheet ◽  
Mohammad Zeed Alzahrani ◽  
Mushtaq Ahmad Ansari ◽  
Ahmed Nadeem ◽  
Khairy M. A. Zoheir ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Mouse Model ◽  
T Regulatory Cell ◽  
Regulatory Cell ◽  
Related Transcription Factor ◽  
Transcription Factor Signaling

scholarly journals Rapamycin Corrects T Regulatory Cell Depletion and Improves Embryo Implantation and Live Birth Rates in a Murine Model

2019 ◽  
Vol 26 (12) ◽  
pp. 1545-1556 ◽  
Author(s):  
Greene Donald Royster ◽  
Justine C. Harris ◽  
Amanda Nelson ◽  
Yessenia Castro ◽  
R. Patrick Weitzel ◽  
...  
Keyword(s):  
Murine Model ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Embryo Implantation ◽  
Mammalian Target Of Rapamycin ◽  
Unexplained Infertility ◽  
Implantation Failure ◽  
T Regulatory Cell ◽  
Recurrent Implantation Failure ◽  
Regulatory Cell

There are few treatments for patients with recurrent pregnancy loss (RPL) or recurrent implantation failure (RIF). Women with RPL and unexplained infertility have lower T regulatory cell (Treg) expression when compared to fertile controls. A murine model has been developed with depletion of regulatory T cells (DEREG) after administration of diphtheria toxin (DT), resulting in smaller litter sizes, secondary to embryo implantation failure. Numerous murine studies have shown that adoptive transfer of CD4+CD25+FoxP3+ Tregs from donors improves litter sizes in DEREG mice with depleted Tregs. Our hypothesis is that DEREG mice treated with a single dose of DT will deplete Tregs and subsequently decrease litter sizes and that treatment with rapamycin (sirolimus; Pfizer) during the time of embryo implantation will increase Tregs and restore litter sizes nearly back to normal levels. Syngeneic mating of DEREG mice after depletion of Tregs resulted in smaller litter sizes and this defect was reversed when these DEREG mice were treated with rapamycin at the time of embryo implantation. The importance of Tregs at the time of embryo implantation has been well established and immunotherapy treatments, such as rapamycin (mammalian target of rapamycin inhibitor), may prove to be an effective treatment for patients with RPL, RIF, or unexplained infertility with low Treg.

Dysregulation of Th1, Th2, Th17, and T regulatory cell-related transcription factor signaling in children with autism

2016 ◽  
Vol 54 (6) ◽  
pp. 4390-4400 ◽  
Author(s):  
Sheikh Fayaz Ahmad ◽  
Khairy M A Zoheir ◽  
Mushtaq Ahmad Ansari ◽  
Ahmed Nadeem ◽  
Saleh A. Bakheet ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Children With Autism ◽  
T Regulatory Cell ◽  
Regulatory Cell ◽  
Related Transcription Factor ◽  
Transcription Factor Signaling

scholarly journals Blockage of FOXP3 transcription factor dimerization and FOXP3/AML1 interaction inhibits T regulatory cell activity: sequence optimization of a peptide inhibitor

Oncotarget ◽  
2017 ◽  
Vol 8 (42) ◽  
pp. 71709-71724 ◽  
Author(s):  
Teresa Lozano ◽  
Marta Gorraiz ◽  
Aritz Lasarte-Cía ◽  
Marta Ruiz ◽  
Obdulia Rabal ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Cell Activity ◽  
Peptide Inhibitor ◽  
T Regulatory Cell ◽  
Sequence Optimization ◽  
Regulatory Cell ◽  
Activity Sequence

T-Regulatory Cell Subsets in Children with Type 1 Diabetes Mellitus: Relation to Control of the Disease

2017 ◽  
Vol 17 (3) ◽  
Author(s):  
Mabrouk M. Ghonaim ◽  
Rawhia H. El-Edel ◽  
Samar M. Kamal Eldein ◽  
Wafaa Moustafa M. Abo El Fotoh ◽  
Samar S. Salman
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
T Regulatory Cell ◽  
Regulatory Cell

scholarly journals IL-7 abrogates memory T regulatory cell functions by modulation of CD39/ATP axis in vitro and in vivo in HIV infected and non-infected patients

Retrovirology ◽  
2012 ◽  
Vol 9 (S2) ◽  
Author(s):  
M Younas ◽  
S Hue ◽  
M Surenaud ◽  
C Lacabaratz ◽  
A Guiguin ◽  
...  
Keyword(s):  
T Regulatory Cell ◽  
Regulatory Cell ◽  
Cell Functions

scholarly journals Factors affecting long-term efficacy of T regulatory cell-based therapy in type 1 diabetes

2016 ◽  
Vol 14 (1) ◽  
Author(s):  
Natalia Marek-Trzonkowska ◽  
Małgorzata Myśliwiec ◽  
Dorota Iwaszkiewicz-Grześ ◽  
Mateusz Gliwiński ◽  
Ilona Derkowska ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Regulatory Cell ◽  
Factors Affecting ◽  
Regulatory Cell ◽  
Term Efficacy ◽  
Cell Based Therapy
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