scholarly journals Association between a functional dopamine D4 receptor promoter region polymorphism (-C521T) and pre-eclampsia: a family-based study

2006 ◽  
Vol 12 (2) ◽  
pp. 85-88 ◽  
Author(s):  
Roman Korobochka ◽  
Inga Gritsenko ◽  
Ron Gonen ◽  
Richard P. Ebstein ◽  
Gonen Ohel
Keyword(s):  
Promoter Region ◽  
Dopamine D4 Receptor ◽  
D4 Receptor ◽  
Family Based

A novel A/G SNP in the ?615th position of the dopamine D4 receptor promoter region as a source of misgenotyping of the ?616 C/G SNP

2004 ◽  
Vol 126B (1) ◽  
pp. 74-78 ◽  
Author(s):  
Z. Ronai ◽  
E. Szantai ◽  
R. Szmola ◽  
Z. Nemoda ◽  
A. Szekely ◽  
...  
Keyword(s):  
Promoter Region ◽  
Dopamine D4 Receptor ◽  
D4 Receptor

Linkage analysis and molecular haplotyping of the dopamine D4 receptor gene promoter region

2005 ◽  
Vol 15 (4) ◽  
pp. 259-270 ◽  
Author(s):  
Eszter Szantai ◽  
Orsolya Kiraly ◽  
Zsofia Nemoda ◽  
Eva Kereszturi ◽  
Zsolt Csapo ◽  
...  
Keyword(s):  
Linkage Analysis ◽  
Promoter Region ◽  
Receptor Gene ◽  
Gene Promoter ◽  
Dopamine D4 Receptor ◽  
D4 Receptor ◽  
Gene Promoter Region

Genotyping the -521C/T functional polymorphism in the promoter region of dopamine D4 receptor (DRD4) gene

2001 ◽  
Vol 22 (6) ◽  
pp. 1102-1105 ◽  
Author(s):  
Zsolt Ronai ◽  
Csaba Barta ◽  
András Guttman ◽  
Krisztina Lakatos ◽  
Judit Gervai ◽  
...  
Keyword(s):  
Promoter Region ◽  
Functional Polymorphism ◽  
Dopamine D4 Receptor ◽  
Drd4 Gene ◽  
D4 Receptor

Recent findings leading to the discovery of selective dopamine D4 receptor ligands for the treatment of widespread diseases

2021 ◽  
Vol 212 ◽  
pp. 113141
Author(s):  
Gianfabio Giorgioni ◽  
Fabio Del Bello ◽  
Pegi Pavletić ◽  
Wilma Quaglia ◽  
Luca Botticelli ◽  
...  
Keyword(s):  
Dopamine D4 Receptor ◽  
Receptor Ligands ◽  
D4 Receptor ◽  
Selective Dopamine

scholarly journals Dopamine D4 receptor gene polymorphism (DRD4 VNTR) moderates real-world behavioural response to the food retail environment in children

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Catherine Paquet ◽  
Andre Krumel Portella ◽  
Spencer Moore ◽  
Yu Ma ◽  
Alain Dagher ◽  
...  
Keyword(s):  
Energy Density ◽  
Food Environment ◽  
Local Food ◽  
Receptor Gene ◽  
Environment Interaction ◽  
Dopamine D4 Receptor ◽  
Vntr Polymorphism ◽  
Food Retailers ◽  
D4 Receptor ◽  
The Impact

Abstract Background Evidence for the impact of the food retailing environment on food-related and obesity outcomes remains equivocal, but only a few studies have attempted to identify sub-populations for whom this relationship might be stronger than others. Genetic polymorphisms related to dopamine signalling have been associated with differences in responses to rewards such as food and may be candidate markers to identify such sub-populations. This study sought to investigate whether genetic variation of the dopamine D4 receptor gene (DRD4 exon III 48 bp VNTR polymorphism) moderated the association between local exposure to food retailers on BMI and diet in a sample of 4 to12-year-old children. Methods Data collected from a birth cohort and a community cross-sectional study conducted in Montreal, Canada, were combined to provide DRD4 VNTR polymorphism data in terms of presence of the 7-repeat allele (DRD4-7R) for 322 children aged between 4 and 12 (M (SD): 6.8(2.8) y). Outcomes were Body Mass Index (BMI) for age and energy density derived from a Food Frequency Questionnaire. Food environment was expressed as the proportion of local food retailers classified as healthful within 3 km of participants’ residence. Linear regression models adjusted for age, sex, income, cohort, and geographic clustering were used to test gene*environment interactions. Results A significant gene*food environment interaction was found for energy density with results indicating that DRD4-7R carriers had more energy dense diets than non-carriers, with this effect being more pronounced in children living in areas with proportionally more unhealthy food retailers. No evidence of main or interactive effects of DRD4 VNTR and food environment was found for BMI. Conclusions Results of the present study suggest that a genetic marker related to dopamine pathways can identify children with potentially greater responsiveness to unhealthy local food environment. Future studies should investigate additional elements of the food environment and test whether results hold across different populations.

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