scholarly journals Down-Regulation ofEPAS1Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia

2017 ◽  
pp. msw280 ◽  
Author(s):  
Yi Peng ◽  
Chaoying Cui ◽  
Yaoxi He ◽  
Ouzhuluobu ◽  
Hui Zhang ◽  
...  
Keyword(s):  
High Altitude ◽  
Genetic Adaptation ◽  
Down Regulation ◽  
Altitude Hypoxia ◽  
High Altitude Hypoxia

Recruitments of Sherpa highlanders and non-Sherpa lowlanders v1

2021 ◽  
Author(s):  
Yunden Droma ◽  
not provided Masayuki Hanaoka ◽  
not provided Masao Ota
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
High Altitude ◽  
Sea Level ◽  
Venous Blood ◽  
Genetic Adaptation ◽  
Nucleotide Polymorphisms ◽  
Research Project ◽  
Single Nucleotide ◽  
Altitude Hypoxia ◽  
High Altitude Hypoxia

In order to carry out the research project of genetic adaptation to high-altitude hypoxia in Sherpa highlanders, we recruited Sherpa highlanders in Namche Bazaar village at a high altitude of 3,440 meters (m) above sea level and non-Sherpa lowlanders in Kathmandu city at 1,300 m in Nepal. Venous blood was sampled to obtain plasma and extract DNA in each subject. The concentrations of factors in plasma were measured. The single-nucleotide polymorphisms (SNPs) in the hypoxia-associated genes were genotyped.

scholarly journals Integrative plasma proteomic and microRNA analysis of Jersey cattle in response to high-altitude hypoxia

2019 ◽  
Vol 102 (5) ◽  
pp. 4606-4618 ◽  
Author(s):  
Zhiwei Kong ◽  
Chuanshe Zhou ◽  
Bin Li ◽  
Jinzhen Jiao ◽  
Liang Chen ◽  
...  
Keyword(s):  
High Altitude ◽  
Altitude Hypoxia ◽  
Jersey Cattle ◽  
High Altitude Hypoxia

Seeding drug discovery: telomeric tankyrase as a pharmacological target for the pathophysiology of high-altitude hypoxia

2021 ◽  
Author(s):  
Manjula Miglani ◽  
Qadar Pasha ◽  
Archana Gupta ◽  
Anjali Priyadarshini ◽  
Ramendra Pati Pandey ◽  
...  
Keyword(s):  
Drug Discovery ◽  
High Altitude ◽  
Altitude Hypoxia ◽  
High Altitude Hypoxia ◽  
Pharmacological Target

Role of Rho kinases in PKG-mediated relaxation of pulmonary arteries of fetal lambs exposed to chronic high altitude hypoxia

2007 ◽  
Vol 292 (3) ◽  
pp. L678-L684 ◽  
Author(s):  
Yuansheng Gao ◽  
Ada D. Portugal ◽  
Sewite Negash ◽  
Weilin Zhou ◽  
Lawrence D. Longo ◽  
...  
Keyword(s):  
High Altitude ◽  
Chronic Hypoxia ◽  
Pulmonary Arteries ◽  
Regulatory Subunit ◽  
Fourth Generation ◽  
Minor Effect ◽  
Altitude Hypoxia ◽  
High Altitude Hypoxia ◽  
Rock Activity

An increase in Rho kinase (ROCK) activity is implicated in chronic hypoxia-induced pulmonary hypertension. In the present study, we determined the role of ROCKs in cGMP-dependent protein kinase (PKG)-mediated pulmonary vasodilation of fetal lambs exposed to chronic hypoxia. Fourth generation pulmonary arteries were isolated from near-term fetuses (∼140 days of gestation) delivered from ewes exposed to chronic high altitude hypoxia for ∼110 days and from control ewes. In vessels constricted to endothelin-1, 8-bromoguanosine-cGMP (8-Br-cGMP) caused a smaller relaxation in chronically hypoxic (CH) vessels compared with controls. Rp-8-Br-PET-cGMPS, a PKG inhibitor, attenuated relaxation to 8-Br-cGMP in control vessels to a greater extent than in CH vessels. Y-27632, a ROCK inhibitor, significantly potentiated 8-Br-cGMP-induced relaxation of CH vessels and had only a minor effect in control vessels. The expression of PKG was increased but was not accompanied with an increase in the activity of the enzyme in CH vessels. The expression of type II ROCK and activity of ROCKs were increased in CH vessels. The phosphorylation of threonine (Thr)696 and Thr850 of the regulatory subunit MYPT1 of myosin light chain phosphatase was inhibited by 8-Br-cGMP to a lesser extent in CH vessels than in controls. The difference was eliminated by Y-27632. These results suggest that chronic hypoxia in utero attenuates PKG-mediated relaxation in pulmonary arteries, partly due to inhibition of PKG activity and partly due to enhanced ROCK activity. Increased ROCK activity may inhibit PKG action through increased phosphorylation of MYPT1 at Thr696 and Thr850.

scholarly journals High-altitude hypoxia and preeclampsia

10.2741/2286 ◽  
2007 ◽  
Vol 12 (8-12) ◽  
pp. 2967 ◽  
Author(s):  
Stacy Zamudio
Keyword(s):  
High Altitude ◽  
Altitude Hypoxia ◽  
High Altitude Hypoxia

scholarly journals High-altitude hypoxia and periodic breathing during sleep: gender-related differences

2013 ◽  
Vol 22 (3) ◽  
pp. 322-330 ◽  
Author(s):  
Carolina Lombardi ◽  
Paolo Meriggi ◽  
Piergiuseppe Agostoni ◽  
Andrea Faini ◽  
Grzegorz Bilo ◽  
...  
Keyword(s):  
High Altitude ◽  
Periodic Breathing ◽  
Altitude Hypoxia ◽  
High Altitude Hypoxia
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