scholarly journals Expression Profile and Gene Age Jointly Shaped the Genome-Wide Distribution of Premature Termination Codons in a Drosophila melanogaster Population

2014 ◽  
Vol 32 (1) ◽  
pp. 216-228 ◽  
Author(s):  
Haiwang Yang ◽  
Bin Z. He ◽  
Huijing Ma ◽  
Shun-Chern Tsaur ◽  
Chenyu Ma ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Expression Profile ◽  
Premature Termination ◽  
Wide Distribution ◽  
Premature Termination Codons ◽  
Genome Wide ◽  
Gene Age

scholarly journals Genes Containing Long Introns Occupy Series of Bands and Interbands in Drosophila melanogaster Polytene Chromosomes

Genes ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 417
Author(s):  
Varvara A. Khoroshko ◽  
Galina V. Pokholkova ◽  
Victor G. Levitsky ◽  
Tatyana Yu. Zykova ◽  
Oksana V. Antonenko ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Polytene Chromosomes ◽  
Housekeeping Genes ◽  
Wide Distribution ◽  
Gene Location ◽  
Gene Arrangement ◽  
Drosophila Genome ◽  
Genetic Organization ◽  
Genome Wide ◽  
Bioinformatic Approaches

The Drosophila melanogaster polytene chromosomes are the best model for studying the genome organization during interphase. Despite of the long-term studies available on genetic organization of polytene chromosome bands and interbands, little is known regarding long gene location on chromosomes. To analyze it, we used bioinformatic approaches and characterized genome-wide distribution of introns in gene bodies and in different chromatin states, and using fluorescent in situ hybridization we juxtaposed them with the chromosome structures. Short introns up to 2 kb in length are located in the bodies of housekeeping genes (grey bands or lazurite chromatin). In the group of 70 longest genes in the Drosophila genome, 95% of total gene length accrues to introns. The mapping of the 15 long genes showed that they could occupy extended sections of polytene chromosomes containing band and interband series, with promoters located in the interband fragments (aquamarine chromatin). Introns (malachite and ruby chromatin) in polytene chromosomes form independent bands, which can contain either both introns and exons or intron material only. Thus, a novel type of the gene arrangement in polytene chromosomes was discovered; peculiarities of such genetic organization are discussed.

scholarly journals Is Esterase-P Encoded by a Cryptic Pseudogene In Drosophila melanogaster?

Genetics ◽  
1996 ◽  
Vol 144 (4) ◽  
pp. 1511-1518
Author(s):  
Evgeniy S Balakirev ◽  
Francisco J Ayala
Keyword(s):  
Drosophila Melanogaster ◽  
Premature Termination ◽  
Indirect Evidence ◽  
Drosophila Species ◽  
Coding Region ◽  
Gene Encoding ◽  
Coding Sequence ◽  
Stop Codons ◽  
Premature Termination Codons

We have amplified and sequenced the gene encoding Esterase-P (Est-P) in 10 strains of Drosophila melanogaster. Three premature termination codons occur in the coding region of the gene in two strains. This observation, together with other indirect evidence, leads us to propose that Est-P may he a pseudogene in D. melanogaster. Est-P would he a “cryptic” pseudogene, in the sense that it retains intact the coding sequence (without stop codons and other alterations usually observed in pseudogenes) in most D. melanogaster strains. We conjecture that the β-esterase cluster may consist in other Drosophila species of functional and nonfunctional genes. We also conjecture that the rarity of detected pseudogenes in Drosophila may he due to the difficulty of discovering them, because most of them are cryptic.

scholarly journals Genome-wide analysis of chimpanzee genes with premature termination codons

BMC Genomics ◽  
2009 ◽  
Vol 10 (1) ◽  
pp. 56 ◽  
Author(s):  
Anna Wetterbom ◽  
Ulf Gyllensten ◽  
Lucia Cavelier ◽  
Tomas F Bergström
Keyword(s):  
Premature Termination ◽  
Genome Wide Analysis ◽  
Premature Termination Codons ◽  
Genome Wide

Genome-wide identification and analysis of maize PAL gene family and its expression profile in response to high-temperature stress

2020 ◽  
Vol 52 (5) ◽  
Author(s):  
De-Gong Wu ◽  
Qiu-Wen Zhan ◽  
Hai-Bing Yu ◽  
Bao-Hong Huang ◽  
Xin-Xin Cheng ◽  
...  
Keyword(s):  
High Temperature ◽  
Gene Family ◽  
Temperature Stress ◽  
Expression Profile ◽  
High Temperature Stress ◽  
Genome Wide

A global analysis of the reconstitution of PTEN function by translational readthrough of PTEN pathogenic premature termination codons

2021 ◽  
Vol 42 (5) ◽  
pp. 551-566
Author(s):  
Sandra Luna ◽  
Leire Torices ◽  
Janire Mingo ◽  
Laura Amo ◽  
Isabel Rodríguez‐Escudero ◽  
...  
Keyword(s):  
Premature Termination ◽  
Global Analysis ◽  
Premature Termination Codons ◽  
Translational Readthrough

scholarly journals Author Correction: Determinants of genome-wide distribution and evolution of uORFs in eukaryotes

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Hong Zhang ◽  
Yirong Wang ◽  
Xinkai Wu ◽  
Xiaolu Tang ◽  
Changcheng Wu ◽  
...  
Keyword(s):  
Wide Distribution ◽  
Genome Wide

A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22435-2

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