scholarly journals The Role of Reverse Transcriptase in Intron Gain and Loss Mechanisms

2011 ◽  
Vol 29 (1) ◽  
pp. 179-186 ◽  
Author(s):  
Noa E. Cohen ◽  
Roy Shen ◽  
Liran Carmel
Keyword(s):  
Reverse Transcriptase ◽  
Intron Gain ◽  
Gain And Loss ◽  
Loss Mechanisms

scholarly journals The role of telomerase reverse transcriptase (TERT) promoter mutations in prognosis in bladder cancer

Bioengineered ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 1495-1504
Author(s):  
Song Wan ◽  
Xuan Liu ◽  
Wei Hua ◽  
Ming Xi ◽  
Yulin Zhou ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Reverse Transcriptase ◽  
Telomerase Reverse Transcriptase ◽  
Tert Promoter ◽  
Tert Promoter Mutations ◽  
Promoter Mutations

Role of Potential Gain and Loss in Choice-Dilemma Decisions

1979 ◽  
Vol 49 (2) ◽  
pp. 617-618
Author(s):  
Richard St. Jean
Keyword(s):  
Potential Gain ◽  
Gain And Loss ◽  
Individual Decisions

The effects of potential gain and loss on choice-dilemma decisions were assessed by experimentally manipulating the content of four choice-dilemma items. Results indicated that the loss manipulation had a major impact on both individual decisions and group shifts, but the gain manipulation did not.

scholarly journals Dissociable oscillatory networks support gain and loss processing in human orbitofrontal cortex

2021 ◽  
Author(s):  
Ignacio Saez ◽  
Jack Lin ◽  
Edward Chang ◽  
Josef Parvizi ◽  
Robert T. Knight ◽  
...  
Keyword(s):  
Neural Activity ◽  
Orbitofrontal Cortex ◽  
Low Frequency ◽  
Brain Regions ◽  
Reward Processing ◽  
Neural Oscillations ◽  
Beta Band ◽  
Neuronal Ensembles ◽  
Gain And Loss

AbstractHuman neuroimaging and animal studies have linked neural activity in orbitofrontal cortex (OFC) to valuation of positive and negative outcomes. Additional evidence shows that neural oscillations, representing the coordinated activity of neuronal ensembles, support information processing in both animal and human prefrontal regions. However, the role of OFC neural oscillations in reward-processing in humans remains unknown, partly due to the difficulty of recording oscillatory neural activity from deep brain regions. Here, we examined the role of OFC neural oscillations (<30Hz) in reward processing by combining intracranial OFC recordings with a gambling task in which patients made economic decisions under uncertainty. Our results show that power in different oscillatory bands are associated with distinct components of reward evaluation. Specifically, we observed a double dissociation, with a selective theta band oscillation increase in response to monetary gains and a beta band increase in response to losses. These effects were interleaved across OFC in overlapping networks and were accompanied by increases in oscillatory coherence between OFC electrode sites in theta and beta band during gain and loss processing, respectively. These results provide evidence that gain and loss processing in human OFC are supported by distinct low-frequency oscillations in networks, and provide evidence that participating neuronal ensembles are organized functionally through oscillatory coherence, rather than local anatomical segregation.

scholarly journals Mechanisms of intron gain and loss in Cryptococcus

2008 ◽  
Vol 9 (1) ◽  
pp. R24 ◽  
Author(s):  
Thomas J Sharpton ◽  
Daniel E Neafsey ◽  
James E Galagan ◽  
John W Taylor
Keyword(s):  
Intron Gain ◽  
Gain And Loss

scholarly journals Multiple intron gain and loss events occurred during the evolution of Cenp-A gene

2013 ◽  
Vol 58 (18) ◽  
pp. 2174-2178 ◽  
Author(s):  
XinYu Fan ◽  
Li Yu ◽  
HuaiLiang Xu ◽  
Ying Li
Keyword(s):  
Intron Gain ◽  
Gain And Loss

scholarly journals Alternative Lengthening of Telomeres and Chromatin Status

Genes ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 45 ◽  
Author(s):  
Ion Udroiu ◽  
Antonella Sgura
Keyword(s):  
Homologous Recombination ◽  
Reverse Transcriptase ◽  
Spatial Heterogeneity ◽  
Telomere Length ◽  
Epigenetic Modifications ◽  
Alternative Lengthening Of Telomeres ◽  
Telomere Elongation ◽  
Alternative Lengthening ◽  
Alt Activity

Telomere length is maintained by either telomerase, a reverse transcriptase, or alternative lengthening of telomeres (ALT), a mechanism that utilizes homologous recombination (HR) proteins. Since access to DNA for HR enzymes is regulated by the chromatin status, it is expected that telomere elongation is linked to epigenetic modifications. The aim of this review is to elucidate the epigenetic features of ALT-positive cells. In order to do this, it is first necessary to understand the telomeric chromatin peculiarities. So far, the epigenetic nature of telomeres is still controversial: some authors describe them as heterochromatic, while for others, they are euchromatic. Similarly, ALT activity should be characterized by the loss (according to most researchers) or formation (as claimed by a minority) of heterochromatin in telomeres. Besides reviewing the main works in this field and the most recent findings, some hypotheses involving the role of telomere non-canonical sequences and the possible spatial heterogeneity of telomeres are given.

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