scholarly journals Origins of Human Malaria: Rare Genomic Changes and Full Mitochondrial Genomes Confirm the Relationship of Plasmodium falciparum to Other Mammalian Parasites but Complicate the Origins of Plasmodium vivax

2008 ◽  
Vol 25 (11) ◽  
pp. 2511-2511 ◽  
Author(s):  
S. W. Roy ◽  
M. Irimia
Keyword(s):  
Plasmodium Falciparum ◽  
Plasmodium Vivax ◽  
Mitochondrial Genomes ◽  
Genomic Changes ◽  
Human Malaria ◽  
Rare Genomic Changes ◽  
Relationship Of ◽  
The Relationship

scholarly journals The relationship of Plasmodium falciparum humeral immunity with HIV-1 immunosuppression and treatment efficacy in Zambia

2009 ◽  
Vol 8 (1) ◽  
pp. 258 ◽  
Author(s):  
Jean-Pierre Van Geertruyden ◽  
Erika Van Eijk ◽  
Francisca Yosaatmadja ◽  
Webster Kasongo ◽  
Modest Mulenga ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Treatment Efficacy ◽  
Relationship Of ◽  
The Relationship ◽  
Hiv 1

scholarly journals Long-Lived Antibody and B Cell Memory Responses to the Human Malaria Parasites, Plasmodium falciparum and Plasmodium vivax

2010 ◽  
Vol 6 (2) ◽  
pp. e1000770 ◽  
Author(s):  
Jiraprapa Wipasa ◽  
Chaisuree Suphavilai ◽  
Lucy C. Okell ◽  
Jackie Cook ◽  
Patrick H. Corran ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
B Cell ◽  
Plasmodium Vivax ◽  
Malaria Parasites ◽  
Cell Memory ◽  
Human Malaria ◽  
B Cell Memory

scholarly journals Biomarkers of cellular aging during a controlled human malaria infection

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Aurelie Miglar ◽  
Isaie J. Reuling ◽  
Xi Zen Yap ◽  
Anna Färnert ◽  
Robert W. Sauerwein ◽  
...  
Keyword(s):  
Cellular Senescence ◽  
Malaria Infection ◽  
Natural Infection ◽  
Parasite Clearance ◽  
Cellular Aging ◽  
Symptom Duration ◽  
Human Malaria ◽  
Controlled Human Malaria Infection ◽  
Relationship Of ◽  
The Relationship

AbstractCellular aging is difficult to study in individuals with natural infection, given the diversity of symptom duration and clinical presentation, and the high interference of aging-related processes with host and environmental factors. To address this challenge, we took advantage of the controlled human malaria infection (CHMI) model. This approach allowed us to characterize the relationship among cellular aging markers prior, during and post malaria pathophysiology in humans, controlling for infection dose, individual heterogeneity, previous exposure and co-infections. We demonstrate that already low levels of Plasmodium falciparum impact cellular aging by inducing high levels of inflammation and redox-imbalance; and that cellular senescence reversed after treatment and parasite clearance. This study provides insights into the complex relationship of telomere length, cellular senescence, telomerase expression and aging-related processes during a single malaria infection.

scholarly journals Complicated malaria: relationship of complications and parasite load to outcome

2018 ◽  
Vol 5 (1) ◽  
pp. 186
Author(s):  
G. Keshava Anand ◽  
Mallikarjun Rao Sanda
Keyword(s):  
Plasmodium Falciparum ◽  
Treatment Plan ◽  
General Medicine ◽  
Parasite Load ◽  
Complicated Malaria ◽  
Appropriate Treatment ◽  
Probability Of Death ◽  
Relationship Of ◽  
The Relationship ◽  
Day By Day

Background: The incidence of complicated malaria cases is increasing day by day. Complicated malaria present in different ways in different places globally. If malaria is diagnosed and treated immediately, then the death rate is less than one percent. The objective was to study the relationship of complications and parasite load to outcome (mortality) among patients with complicated malaria.Methods: The present hospital based Prospective Observational study was carried out among 100 cases of “Complicated malaria.” The present study was carried out at Department of General medicine, Kamineni hospitals, L. B. Nagar, Hyderabad.Results: 71% patients were infected with Plasmodium falciparum, 25% with Plasmodium vivax and 4% with both Plasmodium falciparum and vivax. 12% patients deceased and 88% survived. The relationship between GCS, convulsions, pH, bicarbonate, lactate, hemoglobin, creatinine, SBP, PaO2/FiO2 ratio, PT, INR, aPTT, and outcome was statistically highly significant (p=0.000). The relationship between Total Bilirubin, RBS and outcome was statistically not significant (p=0.351). Multivariate analysis using logistic regression model, to determine the effect of studied variables on the final outcome, revealed no significant influence of studied variables in predicting the outcome (p>0.05). The relationship between increasing parasite load and outcome was studied, and it showed it was statistically highly significant (p=0.000).Conclusions: The prognosis and outcome of patients with complicated malaria worsen as the parasite load increases and the probability of death increases markedly in such patients. The presentation of inappropriate parameters at admission, aid us in predicting poor outcome and appropriate treatment plan.

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