scholarly journals Population Genetics and Geographic Variation of Alcohol Dehydrogenase (Adh) Paralogs and Glucose-6-Phosphate Dehydrogenase (G6pd) in Drosophila mojavensis

2003 ◽  
Vol 21 (2) ◽  
pp. 276-285 ◽  
Author(s):  
L. M. Matzkin
Keyword(s):  
Population Genetics ◽  
Alcohol Dehydrogenase ◽  
Geographic Variation ◽  
Drosophila Mojavensis ◽  
Glucose 6 Phosphate Dehydrogenase

Glucose-6-phosphate dehydrogenase deficiency: a historical perspective

Blood ◽  
2008 ◽  
Vol 111 (1) ◽  
pp. 16-24 ◽  
Author(s):  
Ernest Beutler
Keyword(s):  
Population Genetics ◽  
Molecular Biology ◽  
Historical Perspective ◽  
Dehydrogenase Deficiency ◽  
Clinical Manifestations ◽  
Historical Review ◽  
Human Enzyme ◽  
High Prevalence ◽  
The Many ◽  
Glucose 6 Phosphate Dehydrogenase

Glucose-6-phosphate dehydrogenase deficiency serves as a prototype of the many human enzyme deficiencies that are now known. Since its discovery more than 50 years ago, the high prevalence of the defect and the easy accessibility of the cells that manifest it have made it a favorite tool of biochemists, epidemiologists, geneticists, and molecular biologists as well as clinicians. In this brief historical review, we trace the discovery of this defect, its clinical manifestations, detection, population genetics, and molecular biology.

scholarly journals Electrophoretic Patterns of Oxidoreductases and Other Proteins As Criteria in Fungal Taxonomy

1968 ◽  
Vol 21 (2) ◽  
pp. 275 ◽  
Author(s):  
BG Clare ◽  
NT Flentje ◽  
MR Atkinson
Keyword(s):  
Alcohol Dehydrogenase ◽  
Malate Dehydrogenase ◽  
Soluble Proteins ◽  
Fungal Taxonomy ◽  
Electrophoretic Patterns ◽  
Amido Black ◽  
Starch Gel ◽  
Ph Range ◽  
Starch Gels ◽  
Glucose 6 Phosphate Dehydrogenase

Oxidoreductases and other proteins were extracted from fungi and separated by electrophoresis in starch gels. Isolates of FU8arium, Phytophthora, Pythium, Saccharomyces, Schizosaccharomyces, and Thanatephorus (Rhizoctonia) were used. The main soluble proteins were detected by staining with amido black after electrophoresis in starch gel with a discontinuouA citrate-borate system in the pH range 8�2-9�5. Alcohol dehydrogenase (EC 1.1.1.1.), glucose-6-phosphate dehydrogenase (EC 1.1.1.49), malate dehydrogenase (EC 1.1.1.37), diaphorase (i.e. various NADH2-nitro blue tetrazolium oxidoreductases) and

Differential regulation of duplicate alcohol dehydrogenase genes in Drosophila mojavensis

1983 ◽  
Vol 96 (2) ◽  
pp. 346-354 ◽  
Author(s):  
Philip Batterham ◽  
Janice A. Lovett ◽  
William T. Starmer ◽  
David T. Sullivan
Keyword(s):  
Alcohol Dehydrogenase ◽  
Differential Regulation ◽  
Drosophila Mojavensis

scholarly journals ALLELIC VARIATION AT THE LEVEL OF INTRAGENIC RECOMBINATION

Genetics ◽  
1978 ◽  
Vol 89 (1) ◽  
pp. 211-224
Author(s):  
Michael Freeling
Keyword(s):  
Population Genetics ◽  
Linkage Disequilibrium ◽  
Natural Selection ◽  
Alcohol Dehydrogenase ◽  
Allelic Variation ◽  
Pollen Grains ◽  
Intragenic Recombination ◽  
Naturally Occurring ◽  
Using Data ◽  
Alcohol Dehydrogenase 1

ABSTRACT This report examines five different naturally occurring alcohol dehydrogenase-1 alleles via the recombinational behavior of Adh1  - mutants induced within them. Twenty-two biochemically characterized Adh1  - mutants have been assessed for ability to recombine intragenically, using data generated by specifically staining for the presence of ADH in pollen grains. Each of the five naturally occurring Adh1 progenitor isoalleles appears unique. Allelic variation exists in (1) the rate of intragenic recombination sustained by an allele, and (2) the pattern of recombinational success or failure based on the ancestry of each mutant in a heteroallelic pair. In other words, we find quantitative and qualitative Adh1 allelic variation at the level of intragenic recombination. I have experimentally excluded several explanations for recombinational restriction. These results will be related to the structure, function and naturally occurring variability of the gene in higher organisms. Specifically, the "recon" (unit of recombination) has been resurrected as a potentially useful unit of natural selection. The reasonableness of several genres of hypotheses in evolutionary/population genetics, particularly those involving linkage disequilibrium, is called into question.

scholarly journals Taxonomy, geographic variation and population genetics of Bornean and Sumatran orangutans

Orangutans ◽  
2008 ◽  
pp. 1-14
Author(s):  
Benoît Goossens ◽  
Lounès Chikhi ◽  
Mohd. Fairus Jalil ◽  
Sheena James ◽  
Marc Ancrenaz ◽  
...  
Keyword(s):  
Population Genetics ◽  
Geographic Variation
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