scholarly journals How accurately can we measure the baryon acoustic oscillation feature?

2020 ◽  
Vol 498 (3) ◽  
pp. 3744-3757
Author(s):  
Rossana Ruggeri ◽  
Chris Blake
Keyword(s):  
Asymptotic Variance ◽  
Confidence Region ◽  
Acoustic Oscillation ◽  
Acoustic Oscillations ◽  
Noise Component ◽  
Posterior Probability Distribution ◽  
The Difference ◽  
Definition Of ◽  
The Individual ◽  
The Impact

ABSTRACT Baryon acoustic oscillations (BAOs) represent one of the cleanest probes of dark energy, allowing for tests of the cosmological model through the measurement of distance and expansion rate from a 3D galaxy distribution. The signal appears at large scales in the correlation function where linear theory applies, allowing for the construction of accurate models. However, due to the lower number of modes available at these scales, sample variance has a significant impact on the signal, and may sharpen or widen the underlying peak. Therefore, equivalent mock realizations of a galaxy survey present different errors in the position of the peak when uncertainties are estimated from the posterior probability distribution corresponding to the individual mocks. Hence, the posterior width, often quoted as the error in BAO survey measurements, is subject to sample noise. A different definition of the error is provided by the asymptotic variance of the maximum likelihood estimator, which involves the average over multiple realizations, and is not subject to sample noise. In this work, we reanalyse the main galaxy survey data available for BAO measurements and quantify the impact of the noise component on the error quoted for BAO measurements. We quantify the difference between three definitions of the error: the confidence region computed from a single posterior, the average of the variances of many realizations, and the Fisher matrix prediction assuming a Gaussian likelihood. We also explore the impact of a ‘detectability prior’ based on the significance of the BAO detection.

MOBILE APPLICATION REMOVES SOCIETAL BARRIERS TO P4 MEDICINE

2017 ◽  
pp. 1-3
Author(s):  
J.-P. Michel
Keyword(s):  
Cognitive Abilities ◽  
Mobile Application ◽  
New Technologies ◽  
Global Evaluation ◽  
P4 Medicine ◽  
Fertile Ground ◽  
Definition Of ◽  
The Individual ◽  
The Impact

The overlap between one innovative paradigm (P4 medicine: predictive, personalized, participatory and preventive) and another (a new definition of “Healthy ageing”) is fertile ground for new technologies; a new mobile application (app) that could broaden our scientific knowledge of the ageing process and help us to better analyse the impact of possible interventions in slowing the ageing decline. A novel mobile application is here presented as a game including questions and tests will allow in 10 minutes the assessment of the following domains: robustness, flexibility (lower muscle strength), balance, mental and memory complaints, semantic memory and visual retention. This game is completed by specific measurements, which could allow establishing precise information on functional and cognitive abilities. A global evaluation precedes advice and different types of exercises. The repetition of the tests and measures will allow a long follow up of the individual performances which could be shared (on specific request) with family members and general practitioners.

Coaching skills for recovery a decade of providing coaching skills for recovery training at a healthcare NHS foundation trust

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Helen Kathryn Cyrus
Keyword(s):  
Work Practice ◽  
Clinical Approach ◽  
Personal Recovery ◽  
Content Type ◽  
Coaching Skills ◽  
The Difference ◽  
To Come ◽  
The Individual ◽  
The Impact ◽  
The Brain

Purpose Overview of coaching for recovery. The paper aims to show an overview of work that was carried out over 11 years with groups of mental health and physical staff. As the facilitator who had run this course for the duration in Nottingham, this was an excellent opportunity to be at the forefront of a brand new project. Design/methodology/approach The introduction of the skills are taught over two consecutive days followed by a further day a month later. The idea of coaching is to be enabled to find the answers in themselves by the use of powerful questions and using the technique of the grow model, combined with practice enables the brain to come up with its own answers. Using rapport and enabling effective communication to deliver the outcome. Findings Evidence from staff/clients and the purpose of the paper shows that when you step back it allows the individual patients/staff to allow the brain to process to create to come up with their solutions, which then helps them to buy into the process and creates ownership. Research limitations/implications The evidence suggests that the approach that was there prior to the course was very much a clinical approach to working with clients and treating the person, administering medication and not focussing on the inner person or personal recovery. The staff review has shown that in the clinical context change is happening from the inside out. Practical implications “Helps change culture”; “change of work practice”; “it changed staff focus – not so prescriptive”; “powerful questions let clients come to their own conclusions”; “coaching gives the ability to find half full. Helps to offer reassurance and to find one spark of hope”. Social implications This has shown that the approach is now person-centred/holistic. This has been the “difference that has made the difference”. When this paper looks at the issues from a different angle in this case a coaching approach, applying technique, knowledge and powerful questions the results have changed. The same clients, same staff and same problems but with the use of a different approach, there is the evidence of a different outcome, which speaks for itself. The coaching method is more facilitative, therefore it illicit’s a different response, and therefore, result. Originality/value The results/evidence starts with the individual attending and their commitment to the process over the two-day course. Then going away for the four weeks/six for managers and a commitment again to practice. Returning to share the impact if any with the group. This, in turn, helps to inspire and gain motivation from the feedback to go back to work invigorated to keep going.

Interleukin-10(IL-10)1082-A and Tumor Necrosis Factor(TNF)-Alpha 238/308A Genotypes Are Associated with Earlier (Younger Than 55) Onset of Multiple Myeloma.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 4869-4869
Author(s):  
Meral Beksac ◽  
Merih Kizil ◽  
Ender A. Soydan ◽  
Esin Serbest ◽  
Klara Dalva
Keyword(s):  
Age Of Onset ◽  
Interleukin 10 ◽  
Tnf Alpha ◽  
Nucleotide Polymorphisms ◽  
Promoter Gene ◽  
Age Of Diagnosis ◽  
Definition Of ◽  
The Individual ◽  
The Impact ◽  
Secretory Pattern

Abstract The individual differences among the polymorphic regions of the cytokine genes involved in the pathogenesis of myeloma have been investigated by various groups: Neben et al have found the TNF238 A allel to be associated with a higher serum level of TNF-alpha and with better response to Thalidomide. The IL 10-1082 G promoter gene genotype have been found to be associated with high secretory pattern and in increased frequency among myeloma patients compared to normal controls by Zheng et al. Van Ness et al have reported the IL-10-G genotype to be associated with shorter survival compared to IL-10-A allele carriers None of these groups have analyzed the impact of these genotypes on age of onset. With an aim to analyze the association between the frequencies of the cytokines known to be important in the pathogenesis of Myeloma, TNF-alpha, IL-6, IL-10 and the age of diagnosis, we have isolated DNA from peripheral blood of 59 patients. Patients with a median age of 56(28–83)M/F:35/24 diagnosed and treated in our center between 2002–2004 were analyzed. To determine the TNF 238 and 308(G/A), IL-6 174(G/C), IL-10 1082(G/A),819(T/C) and 592(A/C) bp polymorphic allele frequencies Cytokine Genotyping Kit (Pel-Freeze) and/or Cytgen (OneLambda) Genotyping Trays have been used. Evaluation of results were done as described in the worksheets. Interpretation and definition of phenotypes(low and high secretory patterns) were based on the previously published reports. 30 patients(50,8%) were younger than 56 (median=the cutoff:56). TNF-A homozygous alelle couldnot be observed among all patients. The frequencies of all alleles were: TNF-alfa308A, TNF-alfa238A, IL-10 1082 G 20%, 20%, 12% respectively. IL-6 -GG/GC alleles which have been linked with high secretory pattern constituted the majority of the patients(58/59). When TNFalfa-A were detected based on the 238 bp reactivity the association of low phenotype with elder age was remarkable(p=0.019). This finding wasnot valid for the 308 bp location. IL-10 phenotypes were more complicated with an accumulation in the intermediate level of secretion. The impact of TNF was varified with the separate evaluation of this group, based on their TNF-238/308 genotype, p=0.031). Conclusion: There is a trend towards younger age of onset in Myeloma. Genetic factors for susceptibility have not been defined yet. The new tools for detection of single nucleotide polymorphisms have a promising role in this field. In our prospective study we have found a predominance of low IL-10 secretory A genotype and the high secretory TNF-A genotype among patients younger than 56. To our knowledge this is the first report on such an association. Investigation of other genes in linkeage with TNF on the neighboring MHC region may be necessary for understanding myeloma pathogenesis. Age TNF 238 H/L TNF 308 H/L TNF 238,308 H/L IL-10 H/I/L IL-10 I,TNF H(238 or 308)/ IL-10 I,TNF L(238 or308) L:Low, H: High,I:Intermediate secretory, TNF238A:H, TNF238G:L, TNF308A:H, TNF308G:L, IL-10G: H ≤55 5 / 7 6 / 24 7 / 5 1 /16 / 13 5 / 2 >55 1 / 16 6 / 23 4 / 13 6 /13 / 8 1 / 6 N=29, p=0.019 N=59, p=0.948 N=29, p=0.057 N=57, p=0.085 N=14, p=0.031

scholarly journals The Relationship Between Biomechanical Indicators of the Snatch Technique and Female Weightlifters' Levels

2015 ◽  
Vol 21 (4) ◽  
pp. 218-222 ◽  
Author(s):  
Paulina Szyszka ◽  
Andrzej Mastalerz
Keyword(s):  
Horizontal Displacement ◽  
Biomechanical Analysis ◽  
Maximum Speed ◽  
World Championship ◽  
Margin Of Error ◽  
The World ◽  
The Difference ◽  
Definition Of ◽  
The Individual ◽  
The Relationship

Abstract Introduction. The snatch technique is a discipline in Olympic weightlifting. The lifter has to raise the barbell from the platform directly above their head in one movement. While reviewing the literature on biomechanical analysis of the techniques of weightlifting, one can find positions on the analysis of parameters, such as barbell track, horizontal displacement, and angular positions of the joints in the individual phases of the lifter's movement. Many texts concern female and male lifters taking part in World or European Championships. The parameters of the best competitors are outlined - mostly those who finish in the top five places in competition. Mostly these are parameters regarding male lifters, and less frequently those of female lifters. In the literature review, an overlooked aspect is that of the definition of the diversity of indicators as regards the snatch technique practiced by female lifters depending on score. Material and methods. In the research, registered snatch attempts during the World Championship were used. Videos were used by judges to establish a maximum weight limit for female lifters. The attempts were registered by two cameras and were later digitally processed by the APAS 2000 system. Barbell parameters, maximum speed, average of the bar, and the parameters of the lifter-bar collocation (horizontal displacement of barbell weights and height elevation) were assessed. Results. The analysed attempts show the margin of error for measurement of the average speed of the barbell as 0.03 m/s. The difference in maximum speed of analysed attempts is 15%. The height of clearance of the first-placed female lifter's barbell was 12.7 cm, 30 cm for the last-placed. Conclusions. The sporting level of weightlifting by female lifters influences the analysed biomechanical indicators of the snatch. Those indicators, which are similar in the case of both the World Championship winner and the female lifter who came last, may be described as the average speeds of the barbell. The high sporting level of female lifters performing heavy lifting is characterized by the clearance of the barbell.

scholarly journals IN RELATION TO CONCEPT OF COLLECTIVE HUMAN RIGHTS

2020 ◽  
Vol 36 (4) ◽  
pp. 46-52
Author(s):  
D.A. Gadzhieva ◽  
Keyword(s):  
Human Rights ◽  
Individual Rights ◽  
Group Rights ◽  
Collective Rights ◽  
The Difference ◽  
Definition Of ◽  
The Individual ◽  
Legal Entities

This article is devoted to the analysis of some of the issues related to the definition of the content of the concept of collective human rights. The author examines the issues related to the definition of methods of exercising and the range of subjects of collective rights, some problems concerning their relations with individual rights, as well as whether the term “collective rights of the individual” is a proper one to be used in law science. The author analyzes the difference between the concepts of “collective” and group” rights, and also substantiates the reasons why these categories of human rights cannot be equated or why group rights cannot be singled out into an independent category of individual rights. In addition, the author substantiates the impossibility of possessing of collective rights by legal entities.

scholarly journals Społeczeństwo i kultura jako definicyjny kontekst badań nad wpływem technologii na ponowoczesnego człowieka

2021 ◽  
Vol 65 (1) ◽  
pp. 197-211
Author(s):  
Paweł Piotr Nowak ◽  
Keyword(s):  
Social Relations ◽  
Service Sector ◽  
Social Inequalities ◽  
New Technology ◽  
Digital Transformation ◽  
Negative Consequences ◽  
Philosophy Of Dialogue ◽  
Definition Of ◽  
The Individual ◽  
The Impact

Based on an analysis of selected definitions of the terms used for society and culture, the author creates the sociological theoretical framework for the article. In conjunction with the characterized phenomenon of digital transformation, extensive and far-reaching conclusions are formulated on the impact of new technology for postmodernity. In relation to the scientific achievements of Buber and Tischner, the author deeply analyzes the assumptions of philosophy of dialogue. This allows the observation of a wide dimension in the relationship between the relational nature of social relations, the condition of the individual, the durability of the systems humans create, the technocratic direction of civilizational development and the consumerist attitude to reality in contemporary society of the 21st century. The author describes technological worship and presents the negative consequences of digital transformation processes. On the example of the service sector, the transition is presented as symbolic culture based on the relations and dialogue with technical and functional culture. The research method used in the article is a review of the scientific literature. In the study, the author set the goal of determining the impact of digital transformation on humans in the context of the definition of culture and society. As a result of the research, the author states that technological insight (i.e. looking at technology as a way of resolving all contemporary problems) has the danger of successively weakening man, and could lead to a deepening of social inequalities. The author also emphasizes the need to deepen research on the consequences of the digital transformation on society and culture and to develop models that can reduce the negative consequences of the change process.

scholarly journals TYPES OF INDIVIDUAL WOMEN EROTIC CODE

2018 ◽  
Keyword(s):  
Life Experience ◽  
Married Couples ◽  
Professional Activity ◽  
Self Reflection ◽  
Early Life Experience ◽  
New Material ◽  
Definition Of ◽  
The Individual ◽  
The Impact ◽  
First Time

The article is devoted to the current issue of sexuality. Significant expansion and development of psychologists’ professional activity necessitate creating of generalized classification of individuals and married couples’ behavioral erotic types. The destruction of self-reflection, self-perception and the difficulty of interpersonal understanding are due to the substitution of concepts. The study of sexual-psychological characteristics of behavioral patterns of women in erotic relationships is very important in this regard. The new material on the topic under study is generalized. Erotic imagination functions and erotic images impact on the process of forming a fixed erotic Image of a sexual partner in women are determined. The impact of early life experience (imprinting) influenced on the individual erotic code formation is determined. Several motivational schemes of sexual behavior are described. Authors submit the definition of «individual erotic code» for the first time. «Individual erotic code» is found out as the unified recording system of the individual model erotic behavior and her «ideal partner» reactions on this behavior. The types of women individual erotic code, based on the concept of archetypes (K.G. Jung, D. S. Bolen) study are defined. Types of individual erotic code were named after the ancient Greek goddesses: Artemis, Athena, Hestia, Hera, Demeter, Persephone, Aphrodite. The attention is focused on the deep analysis of individual women erotic code stages realization, such as, the genesis of erotic impulse, the tempting process, the sexual act behavior, the pregnancy, the caring of posterity. Materials of research can be used in the practical work of psychologists and psychotherapists which working both with married couples, as well as in individual work with the client.

scholarly journals دلالة الباء التضمنية و المطابقية في آية الوضوء

2022 ◽  
Vol 6 (1) ◽  
Author(s):  
جيران ، حمد علي هارب
Keyword(s):  
Point Of View ◽  
The Third ◽  
The People ◽  
The Difference ◽  
Definition Of ◽  
The Impact

This research discusses the significance of the underlying and corresponding (B) in the verse of ablution .It consists of a preface , four chapters and a termination .Within the limits of the preface , it dealt with the clarification of the importance of the research .In the first chapter , it dealt with the definition of the underlying significance according to the jurists point of view , also the scientists, point of view who support the underlying significance and the people who agree with them , as well as the aspects of the Hanafia’s and the shafia's inference regarding the implication.   The research also deals with the definition of the corresponding significance according to the jurists' point of view as well as the scientists' point of view who support the correspondence of the (B) significance .These people are the Malikia and the Hanablah and the people who agree with them as well as the aspects of their inference in this issue .The third chapter tackles the more acceptable significance of the two discussed in the former chapters .The final one clarifies the impact of the difference between the underlying and the corresponding (B) according to the jurists' point of view .Finally the research is concluded by the most important deductions.

scholarly journals Criteria for Housing Design with Emphasis on Comparison between Traditional and Today Contemporary Iranian Architecture

2016 ◽  
Vol 9 (6) ◽  
pp. 182
Author(s):  
Tahereh Nasr
Keyword(s):  
Design Pattern ◽  
Field Method ◽  
Traditional Architecture ◽  
Housing Design ◽  
Residential Architecture ◽  
Definition Of ◽  
The Individual ◽  
The Right ◽  
House Design ◽  
The Impact

<p>Settling in the cities and the numerous efforts being made for massive supply of houses in a short time period, makes difficult the access to a pattern as appropriate for family life with increase in concentration in building construction, the individual and family borders, too, are neglected.</p><p>Though due to the extensiveness and complexity of the concept of housing, one cannot give a comprehensive, unique definition of it, but the housing, as a shelter, is regarded as the primary and basic needs of the family.</p><p>House as a place for relaxation and comfort and a shelter for removing tiredness has been a peace and security locality from a long time ago. House demand is one of the most essential human`s demands. According to Article 31 of fundamental law of Islamic Republic of Iran also, possessing a suitable house is considered as the right for every person and every Iranian family. House not only as a shelter, but also as a place for humans raise, has a great importance in the initial and most fundamental society union, namely family.</p><p>Identifying the identity and investigating the residential complexes in regard to the aesthetics implies the precise and conscious observing and noticing their beauties and or ugliness.</p><p>Main Questions in this paper are:</p><ul><li>What are the consequences of disregarding the identity of today's housing architecture, especially the architecture of the ancient towns?</li><li>Can the components of Iranian traditional architecture be applied in today contemporary residential architecture and be effective to create a sense of place?</li></ul><p>So the main purpose of this article is Pathology of Today Contemporary Iranian housing Architecture and Comparison with traditional Iranian architecture.</p><p>The method explored is a descriptive-analytical and field method to gather information and documents are available. The impact of known factors and variables in Iranian contemporary and traditional residential architecture has been evaluated and compared.</p><p>Accordingly, having some criteria for achieving a suitable house design pattern is essential in a way that makes it possible to understand all its visual embodiments and identify its identity.</p>This research also state the reasons for disability of today`s architecture and urban development against house problem and recommend some criteria for achieving a house design pattern after an overview of the definition of housing and examination of Iranian housing.

Histopathological Revision for Gastroenteropancreatic Neuroendocrine Neoplasms in Expert Centers: Does It Make the Difference?

2020 ◽  
Vol 111 (1-2) ◽  
pp. 170-177 ◽  
Author(s):  
Elettra Merola ◽  
Wouter Zandee ◽  
Louis de Mestier ◽  
Heinz Josef Klümpen ◽  
Karolina Makulik ◽  
...  
Keyword(s):  
Standard Of Care ◽  
Clinical Impact ◽  
Neuroendocrine Neoplasms ◽  
Histopathological Diagnosis ◽  
Gastroenteropancreatic Neuroendocrine Neoplasms ◽  
Limited Experience ◽  
Multicenter Analysis ◽  
The Difference ◽  
Definition Of ◽  
The Impact

<b><i>Background:</i></b> The correct histopathological diagnosis of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) is crucial for treatment selection and prognostication. It is also very challenging due to limited experience in nonexpert centers. Revision of pathology is standard of care for most patients who are referred to NEN expert centers. <b><i>Objectives:</i></b> To describe the clinical impact of histopathological revision for GEP-NEN patients referred to an expert center. <b><i>Methods:</i></b> Retrospective multicenter analysis of all GEP-NENs receiving a histopathological revision in 6 European NEN expert centers (January 2016 to December 2016) to evaluate the impact on patient management. <b><i>Results:</i></b> 175 patients were included and 14.7% referred for a second opinion. Histological samples were 69.1% biopsies, 23.4% surgical specimens, and 7.5% endoscopic resections. Histopathological changes due to revision included first assessment of Ki67 in 8.6% of cases, change in grading in 11.4% (3.4% G1 to G2; 5.7% G2 to G1; 0.6% G2 to G3; 1.7% G3 to G2), definition of tumor invasion in 10.8%, additional immunohistochemical staining in 2.3%, diagnosis of mixed adenoneuroendocrine carcinoma in 3.4%, exclusion of NEN in 3.4%, first diagnosis of NEN in 2.3%, and tumor differentiation for G3 in 1.7%. The revision had a clinical impact in 36.0% of patients, leading to a new therapeutic indication in 26.3%. The indication to then perform a new imaging test occurred in 21.1% and recommendation to follow-up with no further treatment in 6.3%. <b><i>Conclusions:</i></b> Histopathological revision in expert centers for NENs can change the diagnosis, with a significant clinical impact in about one third of patients.

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