scholarly journals Chemical models of interstellar cyanomethanimine isomers

2020 ◽  
Vol 497 (1) ◽  
pp. 609-625
Author(s):  
Xia Zhang ◽  
Donghui Quan ◽  
Qiang Chang ◽  
Eric Herbst ◽  
Jarken Esimbek ◽  
...  
Keyword(s):  
Physical Environment ◽  
Reasonable Agreement ◽  
Reaction Network ◽  
Biological Molecules ◽  
Rotational Spectra ◽  
Chemical Models ◽  
Shock Models ◽  
Synthetic Routes ◽  
The Impact ◽  
Green Bank Telescope

ABSTRACT The E-isomer of cyanomethanimine (HNCHCN) was first identified in Sagittarius B2(N) (Sgr B2(N)) by a comparison of the publicly available Green Bank Telescope (GBT) PRIMOS survey with laboratory rotational spectra. Recently, Z-cyanomethanimine was detected in the quiescent molecular cloud G+0.693−0.027 with the IRAM 30-m telescope. Cyanomethanimine is a chemical intermediate in the proposed synthetic routes of adenine, and may play an important role in forming biological molecules in the interstellar medium. Here we present a new modelling study of cyanomethanimine, using the nautilus gas–grain reaction network and code with the addition of over 400 chemical reactions of the three cyanomethanimine isomers and related species. We apply cold isothermal core, hot core, and C-type shock models to simulate the complicated and heterogeneous physical environment in and in front of Sgr B2(N), and in G+0.693−0.027. We identify the major formation and destruction routes of cyanomethanimine, and find that the calculated abundances of the cyanomethanimine isomers and the ratio of Z-isomer to E-isomer are both in reasonable agreement with observations for selected environments. In particular, we conclude that these isomers are most likely formed within or near the hot core without the impact of shocks, or in the cold regions with shocks.

THE IMPACT OF THE PHYSICAL ENVIRONMENT ON RESIDENTS’ SELF-RATED HEALTH: A CASE STUDY IN PENANG, MALAYSIA

2020 ◽  
Vol 6 (1) ◽  
pp. 109
Author(s):  
Massoomeh Hedayati ◽  
Aldrin Abdullah ◽  
Mohammad Javad Maghsoodi Tilaki
Keyword(s):  
Physical Environment ◽  
Fear Of Crime ◽  
Structural Equation ◽  
Well Being ◽  
Living Environment ◽  
Housing Quality ◽  
Self Rated Health ◽  
Environment And Health ◽  
The Impact ◽  
The Relationship

There is continuous debate on the impact of house quality on residents’ health and well-being. Good living environment improves health, and fear of crime is recognised as a mediator in the relationship between physical environment and health. Since minimal studies have investigated the relationship, this study aims to examine the impact of the house quality on fear of crime and health. A total of 230 households from a residential neighbourhood in Malaysia participated in the study. Using structural equation modelling, the findings indicate that housing quality and fear of crime can account for a proportion of the variance in residents’ self-rated health. However, there is no significant relationship between housing quality and fear of crime. Results also show that fear of crime does not mediate the relationship between housing quality and health. This study suggests that the environment-fear relationship should be re-examined theoretically.  

Development of Strategies for Glycopeptide Synthesis: An Overview on the Glycosidic Linkage

2020 ◽  
Vol 24 (21) ◽  
pp. 2475-2497
Author(s):  
Andrea Verónica Rodríguez-Mayor ◽  
German Jesid Peralta-Camacho ◽  
Karen Johanna Cárdenas-Martínez ◽  
Javier Eduardo García-Castañeda
Keyword(s):  
Chemical Synthesis ◽  
Solid Phase ◽  
Building Blocks ◽  
Heterogeneous Environments ◽  
Phase Synthesis ◽  
Low Concentrations ◽  
Biological Sources ◽  
Synthetic Routes ◽  
The Impact ◽  
Potential Use

Glycoproteins and glycopeptides are an interesting focus of research, because of their potential use as therapeutic agents, since they are related to carbohydrate-carbohydrate, carbohydrate-protein, and carbohydrate-lipid interactions, which are commonly involved in biological processes. It has been established that natural glycoconjugates could be an important source of templates for the design and development of molecules with therapeutic applications. However, isolating large quantities of glycoconjugates from biological sources with the required purity is extremely complex, because these molecules are found in heterogeneous environments and in very low concentrations. As an alternative to solving this problem, the chemical synthesis of glycoconjugates has been developed. In this context, several methods for the synthesis of glycopeptides in solution and/or solid-phase have been reported. In most of these methods, glycosylated amino acid derivatives are used as building blocks for both solution and solid-phase synthesis. The synthetic viability of glycoconjugates is a critical parameter for allowing their use as drugs to mitigate the impact of microbial resistance and/or cancer. However, the chemical synthesis of glycoconjugates is a challenge, because these molecules possess multiple reaction sites and have a very specific stereochemistry. Therefore, it is necessary to design and implement synthetic routes, which may involve various protection schemes but can be stereoselective, environmentally friendly, and high-yielding. This review focuses on glycopeptide synthesis by recapitulating the progress made over the last 15 years.

scholarly journals Ethics of Corporeal, Co-present Robots as Agents of Influence: a Review

2021 ◽  
Author(s):  
AJung Moon ◽  
Shalaleh Rismani ◽  
H. F. Machiel Van der Loos
Keyword(s):  
Artificial Intelligence ◽  
Physical Environment ◽  
Ethical Issues ◽  
Human Robot Interaction ◽  
Physical Interaction ◽  
Ethical Challenges ◽  
Natural Tendency ◽  
Ai Ethics ◽  
Recent Trends ◽  
The Impact

Abstract Purpose of Review To summarize the set of roboethics issues that uniquely arise due to the corporeality and physical interaction modalities afforded by robots, irrespective of the degree of artificial intelligence present in the system. Recent Findings One of the recent trends in the discussion of ethics of emerging technologies has been the treatment of roboethics issues as those of “embodied AI,” a subset of AI ethics. In contrast to AI, however, robots leverage human’s natural tendency to be influenced by our physical environment. Recent work in human-robot interaction highlights the impact a robot’s presence, capacity to touch, and move in our physical environment has on people, and helping to articulate the ethical issues particular to the design of interactive robotic systems. Summary The corporeality of interactive robots poses unique sets of ethical challenges. These issues should be considered in the design irrespective of and in addition to the ethics of artificial intelligence implemented in them.

scholarly journals The Impact of the Physical Environment on Intrapartum Maternity Care: Identification of Eight Crucial Building Spaces

2019 ◽  
Vol 12 (4) ◽  
pp. 67-98
Author(s):  
Nicoletta Setola ◽  
Eletta Naldi ◽  
Grazia Giulia Cocina ◽  
Liv Bodil Eide ◽  
Laura Iannuzzi ◽  
...  
Keyword(s):  
Maternity Care ◽  
Physical Environment ◽  
Architectural Design ◽  
Well Being ◽  
Physical Characteristics ◽  
Interdisciplinary Studies ◽  
Room Size ◽  
Direct And Indirect Impacts ◽  
Indirect Impacts ◽  
The Impact

Objectives, Purpose, or Aim: This article investigates whether the physical environment in which childbirth occurs impacts the intrapartum intervention rates and how this might happen. The study explores the spatial physical characteristics that can support the design of spaces to promote the health and well-being of women, their supporters, and maternity care professionals. Background: Medical interventions during childbirth have consequences for the health of women and babies in the immediate and long term. The increase in interventions is multifactorial and may be influenced by the model of care adopted, the relationships between caregivers and the organizational culture, which is made up of many factors, including the built environment. In the field of birth architecture research, there is a gap in the description of the physical characteristics of birth environments that impact users’ health. Method: A scoping review on the topic was performed to understand the direct and indirect impacts of the physical environment on birth intervention rates. Results and Discussion: The findings are organized into three tables reporting the influence that the physical characteristics of a space might have on people’s behaviors, experiences, practices and birth health outcomes. Eight building spaces that require further investigation and research were highlighted: unit layout configuration, midwives’ hub/desk, social room, birth philosophy vectors, configuration of the birth room, size and shape of the birth room, filter, and sensory elements. Conclusions: The findings show the importance of considering the physical environment in maternity care and that further interdisciplinary studies focused on architectural design are needed to enrich the knowledge and evidence on this topic and to develop accurate recommendations for designers.

scholarly journals Investigating pedestrians’ obstacle avoidance behaviour

2020 ◽  
Vol 5 ◽  
Author(s):  
Abdullah Alhawsawi ◽  
Majid Sarvi ◽  
Milad Haghani ◽  
Abbas Rajabifard
Keyword(s):  
Physical Environment ◽  
Simulation Models ◽  
Avoidance Behaviour ◽  
Movement Direction ◽  
Total Speed ◽  
Lateral Direction ◽  
Video Recordings ◽  
High Speeds ◽  
The Impact ◽  
Pedestrian Simulation

Modelling and simulating pedestrian motions are standard ways to investigate crowd dynamics aimed to enhance pedestrians’ safety. Movement of people is affected by interactions with one another and with the physical environment that it may be a worthy line of research. This paper studies the impact of speed on how pedestrians respond to the obstacles (i.e. Obstacles avoidance behaviour). A field experiment was performed in which a group of people were instructed to perform some obstacles avoidance tasks at two levels of normal and high speeds. Trajectories of the participants are extracted from the video recordings for the subsequent intentions:(i) to seek out the impact of total speed, x and yaxis (ii) to observe the impact of the speed on the movement direction, x-axis, (iii) to find out the impact of speed on the lateral direction, y-axis. The results of the experiments could be used to enhance the current pedestrian simulation models.

scholarly journals The impact of the third O2 addition reaction network on ignition delay times of neo-pentane.

2020 ◽  
Author(s):  
Nils Hansen ◽  
G. Kukkadapu ◽  
B. Chen ◽  
S. Dong ◽  
HJ Curran ◽  
...  
Keyword(s):  
Ignition Delay ◽  
Addition Reaction ◽  
Reaction Network ◽  
The Third ◽  
Ignition Delay Times ◽  
Delay Times ◽  
The Impact

Predicting change in biogeochemical potential of subsurface systems with changing hydrogeological conditions

2021 ◽  
Author(s):  
Swamini Khurana ◽  
Falk Heße ◽  
Martin Thullner
Keyword(s):  
Water Quality ◽  
Preferential Flow ◽  
Nutrient Loading ◽  
Temporal Dynamics ◽  
Reaction Network ◽  
Climate Scenario ◽  
Ecosystem Functions ◽  
External Forcing ◽  
Spatio Temporal ◽  
The Impact

<p>In a changing climate scenario, we expect weather event patterns to change, both in frequency and in intensity. The subsequent impacts of these changing patterns on ecosystem functions are of great interest. Water quality particularly is critical due to public health concerns. Already, seasonal variation of water quality has been attributed to varying microbial community assemblages and nutrient loading in the corresponding water body but the contribution of the variations in the quantity of groundwater recharge is a missing link. It is thus beneficial to establish links between external forcing such as changing infiltration rate or recharge on nutrient cycling in the subsurface. We undertake this study to investigate the impact of temporal variation in external forcing on the biogeochemical potential of spatially heterogeneous subsurface systems using a numerical modeling approach. We used geostatistical tools to generate spatial random fields by considering difference combinations of the variance in the log conductivity field and the anisotropy of the domain. Tuning these two parameters assists in effective representation of a wide variety of geologic materials with varying intensity of preferential flow paths in the heterogeneous domain. We ran simulations using OGS#BRNS that enables us to combine a flexibly defined microbial mediated reaction network with the mentioned spatially heterogeneous domains in transient conditions. We propose that a combination of estimated field indicators of Damköhler number, Peclet number (transformed Damköhler number: Da<sub>t</sub>), and projected temporal dynamics in surface conditions can assist us in predicting the change in biogeochemical potential of the subsurface system. Preliminary results indicate that we miss potentially critical variations in reactive species concentration if we neglect spatio-temporal heterogeneities for regimes where 1<Da<sub>t</sub><40. For regimes characterized by values outside this range, we propose that spatio-temporal heterogeneities due to subsurface structure and changing hydrological forcing may not be relevant.</p>

The Impact of Physical Environment on the Cognitive Function of the Elderly: A Scoping Review of Cohort Studies

2021 ◽  
pp. 108482232110588
Author(s):  
Jihye Kim ◽  
Jiyeong Lee ◽  
Jihye Park ◽  
Hakseong Kim ◽  
Ingyu Yoo
Keyword(s):  
Cognitive Function ◽  
Physical Environment ◽  
Relevant Literature ◽  
The Elderly ◽  
Residential Density ◽  
Living Space ◽  
Rural Environments ◽  
Care Facilities ◽  
Urban Rural ◽  
The Impact

This review examined whether the physical environment can change the cognitive function of the elderly and categorized the specific environmental types. Four databases, CINAHL, Embase, PubMed, and PsycINFO, were searched for relevant literature published as of December 2020. The framework used was proposed by Arksey and O’Malley, which includes a 5-stage review process. A total of 12 studies were examined. The physical environments with similar characteristics, among all the environmental elements, were grouped together into 4 categories: residential density and road connectivity, limited living space, urban/rural, and care facilities. Residential density and road connectivity, limited living space, and care facilities were found to have a significant effect on the cognitive function of the elderly. However, there was no significant effect on the cognitive function of the elderly when comparing the urban and rural environments. Although studies on environments that affect the cognitive function of the elderly are still ongoing, the ones analyzing specific environments in detail are insufficient. With the increasing importance of the role played by the environment in the cognitive impairment of the elderly, detailed studies on specific environments among the various environmental factors surrounding the elderly, such as this study, should be conducted more actively.

Creating Optimal Healing Environments

2018 ◽  
pp. 371-389
Author(s):  
Terri Zborowsky ◽  
Mary Jo Kreitzer
Keyword(s):  
Physical Environment ◽  
Community Hospital ◽  
Healing Environment ◽  
Ambient Environment ◽  
Health And Wellbeing ◽  
Designed Environment ◽  
Healing Environments ◽  
The Impact ◽  
Dynamic Interplay

An optimal healing environment is created through the deep and dynamic interplay between people, place, process and culture. Over 1,000 papers have been published linking the physical environment to outcomes related to patients and staff. Integrative nurses are well positioned to be leaders in the planning of healing spaces. This chapter defines “healing environment”; describes research on the impact of the designed environment; and discusses the effects of such factors as nature, daylight, positive distractions, aesthetics (including color), and an ambient environment on health and wellbeing. A case study of an optimal healing environment using North Hawaii Community Hospital is presented.

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