scholarly journals Defeaters and Disqualifiers

Mind ◽  
2018 ◽  
Vol 128 (511) ◽  
pp. 887-906 ◽  
Author(s):  
Daniel Muñoz

Abstract Justification depends on context: even if E on its own justifies H, still it might fail to justify in the context of D. This sort of effect, epistemologists think, is due to defeaters, which undermine or rebut a would-be justifier. I argue that there is another fundamental sort of contextual feature, disqualification, which doesn't involve rebuttal or undercutting, and which cannot be reduced to any notion of screening-off. A disqualifier makes some would-be justifier otiose, as direct testimony sometimes does to distal testimony, and as manifestly decisive evidence might do to gratuitous evidence on the same team. Basing a belief on disqualified evidence, moreover, is distinctively irrational. One is not necessarily irresponsible. Instead one is turning down a free upgrade to a sleeker, stabler basis for one's beliefs. Such an upgrade would prevent wastes of epistemic effort, since someone who bases her belief on a disqualified proposition E will need to remember E and rethink her belief should E ever be defeated. The upgrade might also reduce reliance on unwieldy evidence, if E is relevant only thanks to some labyrinthine argument; and if even ideal agents should doubt their ability to follow such arguments, even they should care about disqualifiers.

2006 ◽  
Vol 36 (18) ◽  
pp. 59
Author(s):  
ERIK GOLDMAN
Keyword(s):  

2018 ◽  
Vol 52 (4) ◽  
pp. 39
Author(s):  
Jan Czerniawski

Dowód twierdzenia Bella sprowadza się do wyprowadzenia którejś z nierówności Bella. W ich standardowych wyprowadzeniach jednak kluczową rolę odgrywa warunek faktoryzowalności łącznego prawdopodobieństwa warunkowego, który można uzyskać jako konsekwencję dwóch innych warunków, znanych jako parameter independence i outcome independence. Pierwszy z nich jest dość oczywistym wyrazem warunku lokalności, natomiast drugi budzi wątpliwości. Ponieważ jednak jest on uszczegółowieniem warunku screening off zasady wspólnej przyczyny, jego podważenie wymagałoby zakwestionowania również tego warunku. Gdyby się to powiodło, efektywny dowód twierdzenia Bella wymagałby wyprowadzenia nierówności Bella nie wykorzystującego żadnego uszczegółowienia warunku screening off. Przestawiona zostanie sugestia kierunku, w jakim powinny iść poszukiwania modelu naruszającego ten warunek.


1992 ◽  
Vol 59 (1) ◽  
pp. 142-152 ◽  
Author(s):  
Elliott Sober

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 617
Author(s):  
Guoqing Bao ◽  
Xiuying Wang ◽  
Ran Xu ◽  
Christina Loh ◽  
Oreoluwa Daniel Adeyinka ◽  
...  

We have developed a platform, termed PathoFusion, which is an integrated system for marking, training, and recognition of pathological features in whole-slide tissue sections. The platform uses a bifocal convolutional neural network (BCNN) which is designed to simultaneously capture both index and contextual feature information from shorter and longer image tiles, respectively. This is analogous to how a microscopist in pathology works, identifying a cancerous morphological feature in the tissue context using first a narrow and then a wider focus, hence bifocal. Adjacent tissue sections obtained from glioblastoma cases were processed for hematoxylin and eosin (H&E) and immunohistochemical (CD276) staining. Image tiles cropped from the digitized images based on markings made by a consultant neuropathologist were used to train the BCNN. PathoFusion demonstrated its ability to recognize malignant neuropathological features autonomously and map immunohistochemical data simultaneously. Our experiments show that PathoFusion achieved areas under the curve (AUCs) of 0.985 ± 0.011 and 0.988 ± 0.001 in patch-level recognition of six typical pathomorphological features and detection of associated immunoreactivity, respectively. On this basis, the system further correlated CD276 immunoreactivity to abnormal tumor vasculature. Corresponding feature distributions and overlaps were visualized by heatmaps, permitting high-resolution qualitative as well as quantitative morphological analyses for entire histological slides. Recognition of more user-defined pathomorphological features can be added to the system and included in future tissue analyses. Integration of PathoFusion with the day-to-day service workflow of a (neuro)pathology department is a goal. The software code for PathoFusion is made publicly available.


Erkenntnis ◽  
2021 ◽  
Author(s):  
David Atkinson ◽  
Jeanne Peijnenburg

AbstractAs is well known, implication is transitive but probabilistic support is not. Eells and Sober, followed by Shogenji, showed that screening off is a sufficient constraint for the transitivity of probabilistic support. Moreover, this screening off condition can be weakened without sacrificing transitivity, as was demonstrated by Suppes and later by Roche. In this paper we introduce an even weaker sufficient condition for the transitivity of probabilistic support, in fact one that can be made as weak as one wishes. We explain that this condition has an interesting property: it shows that transitivity is retained even though the Simpson paradox reigns. We further show that by adding a certain restriction the condition can be turned into one that is both sufficient and necessary for transitivity.


2003 ◽  
Vol 10 (1/2) ◽  
pp. 45-52 ◽  
Author(s):  
R. E. Ergun ◽  
L. Andersson ◽  
C. W. Carlson ◽  
D. L. Newman ◽  
M. V. Goldman

Abstract. Direct observations of magnetic-field-aligned (parallel) electric fields in the downward current region of the aurora provide decisive evidence of naturally occurring double layers. We report measurements of parallel electric fields, electron fluxes and ion fluxes related to double layers that are responsible for particle acceleration. The observations suggest that parallel electric fields organize into a structure of three distinct, narrowly-confined regions along the magnetic field (B). In the "ramp" region, the measured parallel electric field forms a nearly-monotonic potential ramp that is localized to ~ 10 Debye lengths along B. The ramp is moving parallel to B at the ion acoustic speed (vs) and in the same direction as the accelerated electrons. On the high-potential side of the ramp, in the "beam" region, an unstable electron beam is seen for roughly another 10 Debye lengths along B. The electron beam is rapidly stabilized by intense electrostatic waves and nonlinear structures interpreted as electron phase-space holes. The "wave" region is physically separated from the ramp by the beam region. Numerical simulations reproduce a similar ramp structure, beam region, electrostatic turbulence region and plasma characteristics as seen in the observations. These results suggest that large double layers can account for the parallel electric field in the downward current region and that intense electrostatic turbulence rapidly stabilizes the accelerated electron distributions. These results also demonstrate that parallel electric fields are directly associated with the generation of large-amplitude electron phase-space holes and plasma waves.


Synthese ◽  
2021 ◽  
Author(s):  
David Atkinson ◽  
Jeanne Peijnenburg

AbstractEells and Sober proved in 1983 that screening off is a sufficient condition for the transitivity of probabilistic causality, and in 2003 Shogenji noted that the same goes for probabilistic support. We start this paper by conjecturing that Hans Reichenbach may have been aware of this fact. Then we consider the work of Suppes and Roche, who demonstrated in 1986 and 2012 respectively that screening off can be generalized, while still being sufficient for transitivity. We point out an interesting difference between Reichenbach’s screening off and the generalized version, which we illustrate with an example about haemophilia among the descendants of Queen Victoria. Finally, we embark on a further generalization: we develop a still weaker condition, one that can be made as weak as one wishes.


2020 ◽  
Vol 22 (2) ◽  
pp. 307-321
Author(s):  
Spencer Case ◽  

Many philosophers have thought that aggregates of small, broadly dispersed evils don’t pose the same sort of challenge to theism that horrendous evils like the Nazi Holocaust do. But there are interesting arguments that purport to show that large enough aggregates of small evils are morally and axiologically equivalent to horrendous evils. Herein lies an intriguing and overlooked strategy for defending theism. In short: small evils, or aggregates of such evils, don’t provide decisive evidence against theism; there’s no relevant difference between horrendous evils and aggregates of small evils; hence horrendous evils must not provide decisive evidence against theism, either.


1968 ◽  
Vol 23 (1) ◽  
pp. 25-30 ◽  
Author(s):  
J. Clauwaert ◽  
J. Stockx

The pK' values of the current bases, nucleosides, nucleotides, nucleotide derivatives and poly U have been determined over a large range of ionic strength. The pK' shifts of the monomers due to variations in ionic strength can be accounted for qualitatively and quantitatively by means of the relationThe collision diameters of uracil, uridine, uridine cyclic -2':3'-phosphate and 3' (2') -uridylic acid were determined. The introduction of phosphate affects the charge, resulting into differences in activity coefficient between nucleotides and their corresponding nucleosides and bases. A substitution of -H by ribose at N(3) of uracil or cytosine or at N(9) of adenine or guanine results into an electron withdrawal from the bases with lowering of the pK' value. 2'-Deoxyribose exhibits a weaker electron attraction. Introducing -CH3 at C(5) of uracil yields electrons to the base and the pK values of various thymine derivatives are about 0.5 pH units higher than those of the corresponding uracil derivatives. A phosphate group on C2 or C3 results in an electrostatic attraction of the dissociable proton, so that the pK' is increased at low ionic strengths; at higher ionic strengths screening off occurs and the pK' values of the nucleotides become almost the same as those of the corresponding nucleosides. The site of substitution on the ribose moiety is important: C2'-O-phosphate seems to exert a stronger electrostatic attraction on - NH3⊕ groups than C3'-O-phosphate, whereas C5'-O-phosphate exerts in addition an inductive effect that is dependent on the presence of - OH on C2. The electrostatic influence of the phosphate groups on the uracil moiety in UpU, UpC and CpUpC runs roughly parallel to that found in cyclic-2':3'-nucleotides. The pK' shifts experienced in poly U are related to the polyelectrolyte character of this polymer. A new treatment for the evaluation of the electrostatic potential of polynucleotides (poly U) is proposed that is based on the usual rodlike (polyelectrolyte) model.


2012 ◽  
pp. 459-469 ◽  
Author(s):  
Yituo Ye ◽  
Lei Qin ◽  
Zhongwei Cheng ◽  
Qingming Huang

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